Mice that are 75 years old human equivalent extended lifespan by 73%.
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Amazing! Anyone has tried oxytocin? Besides hugging someone is there other way to supplement it?
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Extended REMAINING lifespan.
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It is available as a peptide powder that is reconstituted with bacteriostatic water and used as a nasal spray or injected. The proper dosage might be a little hard to figure out.
It is normally injected or used as a nasal spray because stomach acids destroy it.
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See published paperā¦calculate the dose.
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Right. A 73% increase from the time of treatment, which is a lot of hand-waving, and overall a 14% increase, which is good but not spectacular.
āTreatment of old frail male mice with OT+A5i resulted in a remarkable 73 per cent life extension from that time, and a 14 per cent increase in the overall median lifespan,ā researchers wrote.
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It is spectacular, given how late in life it was started. I wonder why they chose to start it so late. Would be great to see mid life start or earlier.
Iāve tried it. I just used it. Makes me feel calm. Right after administering it I notice a flushing effect like niacin but not as bad, an increased heart rate and sometimes a weird metallic taste in my mouth.
Iām experimenting with it before bed to see if it helps with sleep. Before I used it to see if it improved social interaction but I didnāt like having to use a nasal spray or injection timed with social interactions so I think having this before bed will be an easier experiment.
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Its another way of switching the autonomous nervous system into parasympathetic.
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Sounds good to me.
I was just checking in on if the proposed interventions for RMR2 had changed and noticed that oxytocin was on there so I figured Iād look a bit more into it and give it another go. I have a bunch of vials of oxytocin so I may as well use them. Robust Mouse Rejuvenation - Study 2 ā LEV Foundation
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Can I ask if you will share your supplier details please?
Or anyone else?
Iāve been wanting to try oxytocin for a while but itās always been too hard to source.
Dr T,
I frequently receive marketing emails about their nasal spray from gethealthspan.com Maybe there are better priced options out there ?
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Oxytocin sources:
Nootropic Source and Base Peptides have both the nasal spray and injectables.
I have used Nootropic Source many times; they have been around for many years, and I have been satisfied with their products.
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I got it off SSA but that company has shut down. You can find other peptide suppliers on peptide.chat
Can you identify any potential translational ideas on how the discoveries in the research paper may be applied to humans?
CGPT 5.1 Response:
Most Realistic Translational Pathways (Ranked)
Tier 1: Immediately testable in humans
- Intermittent intranasal oxytocin for frailty episodes, sarcopenia recovery, or cognitive support in older adults
- Antifibrotic lifestyle strategies (exercise, weight loss, glycation reduction) mapped to TGF-Ī² pathways
- Proteomic variance as a biomarker via Olink/SomaScan
Tier 2: Near-term drug development (2ā5 years)
- Low-dose, cyclic ALK5 inhibition in fibrosis-prone older adults
- Combination therapy trials pairing antifibrotic + pro-regenerative agents
- Sex-specific dosing regimens for TGF-Ī² and oxytocin modulators
- Frailty-focused endpoints rather than lifespan proxies
Tier 3: Longer-term and higher risk (5ā10 years)
-
Full āgeroprotector cocktailsā consisting of:
- TGF-Ī² partial inhibitor
- OT analog / agonist
- AMPK activator
- Senolytic pulse
- Anti-fibrotic diet/exercise protocol
- Precision proteomic homeostasis tools (AI-based noise-reduction modeling)
Bottom Line
The paperās most important translational lesson is not that humans should take oxytocin or ALK5 inhibitors today.
The key insight is aging may be reversible via correcting imbalances between pro-fibrotic / inflammatory pathways (TGF-Ī²) and regenerative / anabolic pathways (OT).
This suggests a future class of calibrated, multi-pathway geroprotective cyclesāwith sex-specific tuning and proteomic-noise monitoring.
Full Chat GPT Analysis:
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To: Beth, Desert Shores and Australialongevity,
Thank you for your helpful replies. I will do some searching.
Kind regards
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What kind of dosage did you try?
Honestly hard to say. I have 10mg vials, I put 2mL bacteriostatic water in them. I use maybe 1 unit or less of an insulin syringe and it has quite a profound effect. You donāt need much.
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