Dihydromyricetin (or DHM in iHerb) can modulate the TGF‑β/Smad pathway, ALK5 inhibitors block this receptor to prevent Smad2/3 (and in some contexts Smad1/5) activation. Don’t know if DHM + Oxytocin can a low cost alternative to achieve similar results.
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I doubt it, but who knows? DHM seems like a dirty drug, with poor availability (it’s the type of thing the body will detoxify rapidly). The research for both safety in large doses and effect is sparse.
Pirfenidone is a possibility, among the things you can buy off the shelf. “Galunisertib” is AFAIK the only human tested ALK5i with a publicly known structure. It failed it’s cancer trial and there’s no ready supply.
I use OT in a nasal spray with a dose of 25mcg per spray, I often do 2 to 4 sprays a day.
I’ve never used it as an injectable. For brain health nasal sprays are often more effective, as that is a more direct path to the brain.
5mg OT in 24mL BAC water provides 200 sprays of 25mcg. Spray bottles are available on Amazon
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I bought some spray bottles to use but they didn’t have a hole in them so they didn’t work lol. I decided to just subQ inject.
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I’ve renewed my interest in Oxytocin and now do an injection of 17iu (25mcg) in the morning and 2 nasal sprays of 17iu x2 = 34iu just before bed.
Widespread Oxytocin Receptor Expression Suggests a (1).pdf (768.6 KB)
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Any particular reason you take it right before bed? Does it affect sleep or dreams?
My first interest in Oxytocin was piqued by the effect it has on the glymphatic system.
Oxytocin effect on the glymphatic system.pdf (461.6 KB)
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Steve_Combi,
Are you still using oxytocin? If so, do you mind telling me your protocol and the effects you notice? And, can you compare effects from intranasal versus subq? If you still use it I assume you like the benefits?
Thanks for your time,
Jay
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Yes, both a nasal spray and a subQ injection. Very low dose for both.
I don’t notice much with the nasal dose as I take it just before bed.
The subQ dose in the morning I do notice as it does a slight but noticeable “warming” sensation for 5 or 6 minutes.
Nasal has a greater effect on the brain aspect, glymphatic, etc
SubQ has a greater effect on the body.
I think both methods of administration are longevity oriented from the papers I’ve read and posted.
I’ve dealt with high level conflict on a regular basis the past 3 years. Have been assaulted by homeless on 4 occasions as part of my duties. So far, have evicted 48 encampments off the property my partners own. As a result of that contact with over 200 homeless drug addicts, managing my stress response is important. I think OT has helped me with that.
Overall I’m a pretty happy guy. I doubt Oxytocin has changed anything in that area for me and I’ve always been a “selectively” social type. Never had to be with people to be happy and engaged in life (only child) but enjoy company when it’s around. So the purported social aspects of oxytocin are not jumping out at me.
I just feel good mentally, solid, stable, getting stuff done every day and loving life 
At 70 I can’t ask for more than that.
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Interesting, but I thought you need a special solution (not just BAC) to make it sprayable. Are you 100% sure that BAC is all you need. Thanks,
The only issue with bac is that it irritates the nasal cavity, and thus can be unpleasant. Saline is the other reconstitution solution some people advocate for. Plain steril water is also an alternative. In either case, filtering the soltution after reconstitution would be advisable to remove mold, spores, bacteria, etc.
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Thanks, but how do these 3 (saline, BAC, and plain sterile water) compare with regards to the expiry/loss of effectiveness after reconstituting, if known?
I would keep for the standard 30 days for effectiveness, I haven’t seen any degradation tests for this particular peptide. When comparing the solution themselves, I would be more worried about sterility and bacterial growth than their influence on peptide degradation (that likely doesn’t matter). Bacteriostatic water provides the best protection against that, but comes with the caveats mentioned above.
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I don’t use BAC water anymore, distilled water works fine. If you wanted to add a small amount of Hyaluronic acid to provide some moisturization and stickiness that would be about all I’d do.
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