Dihydromyricetin (or DHM in iHerb) can modulate the TGF‑β/Smad pathway, ALK5 inhibitors block this receptor to prevent Smad2/3 (and in some contexts Smad1/5) activation. Don’t know if DHM + Oxytocin can a low cost alternative to achieve similar results.
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I doubt it, but who knows? DHM seems like a dirty drug, with poor availability (it’s the type of thing the body will detoxify rapidly). The research for both safety in large doses and effect is sparse.
Pirfenidone is a possibility, among the things you can buy off the shelf. “Galunisertib” is AFAIK the only human tested ALK5i with a publicly known structure. It failed it’s cancer trial and there’s no ready supply.
I use OT in a nasal spray with a dose of 25mcg per spray, I often do 2 to 4 sprays a day.
I’ve never used it as an injectable. For brain health nasal sprays are often more effective, as that is a more direct path to the brain.
5mg OT in 24mL BAC water provides 200 sprays of 25mcg. Spray bottles are available on Amazon
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I bought some spray bottles to use but they didn’t have a hole in them so they didn’t work lol. I decided to just subQ inject.
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