Optimal Blood Pressure we Should Target? Systolic Under 110 or 100?

Telmisartan is the only BP med I am taking. I was taking 40 mg, but 20 mg in the morning seems better. I do take citrulline at night which also helps.

My BP seems to be staying pretty consistent all day long as measured by my Contec device at home.

3 Likes

Am planning up my Temisartan to 80mg per @DrFraser recommendation here.

Anyone else who has tried 80mg and what are the result of it?

I have been taking 80mg telmisartan for the better part of a year now. My systolic runs about 10-15 mmHg lower than when it was untreated. I haven’t had any issues.

4 Likes

I started telmisartan 2 years ago in order to drive BP down to below 130.

Although 40mg was sufficient when measured at home, I was still getting high readings (over 130) in the doctors office.

I’ve now been at 80 mg for about a year, getting home BP readings typically at or below 110 SP. To prevent occasional lightheadedness due to DP in the mid 50’s, I found that splitting the dosage to 40mg twice a day solved that issue.

4 Likes

I have had the same experience. I’m rushing to an appointment, stressed, SBP is 135, which at rest is 115. This is stress. I think it’s that simple, and I don’t think it’s something to get stressed about. Lol.

My resting HR is also high and has always been high, despite the fact that I have good body composition and aerobic fitness and have never smoked. My resting HR is around 70, while my athletic friends, whom I have trouble keeping pace with on a hike, will be in the 60s. Some of us are just clocked differently. I’m not saying we shouldn’t try to do something about it, but I think our baseline is different.

2 Likes

I have HR and BP measures back to 2016, but more detailed records more recently. The BP/HR measures are, however, comparable.

I used to have a HR in the 70s 80s and now it is in the 50s. I don’t think that is genetic.

1 Like

For the record, I’m not saying that behavioural changes or pharmacology aren’t influential—perhaps more influential than genetics. I’m saying that genetic influence on pulse rate should be considered when developing a strategy for pulse-rate reduction. Because you have been successful in reducing your heart rate by doing whatever you did, it does not mean I can expect the same results following the same plan. We see this in most biomarkers we try to influence, glucose, fat, apob, etc.

1 Like

John - what do you think the key factors are that helped you accomplish this HR reduction?

2 Likes

Its hard to identify one or two changes.

Researchers at the University of California, San Diego School of Medicine have identified a potential new treatment for individuals with uncontrolled or treatment-resistant hypertension, a condition commonly referred to as high blood pressure. The investigational drug, lorundrostat, showed encouraging results in a recent clinical trial.

Published in the New England Journal of Medicine, the study found that participants who received lorundrostat experienced an average 15-point reduction in systolic blood pressure, the upper number in a blood pressure reading, compared to a 7-point reduction in those given a placebo.

https://scitechdaily.com/scientists-have-found-a-drug-that-slashes-blood-pressure-in-weeks/

2 Likes

I’ve been taking telmisartan for about 5 months, bumping up to 80mg not long after I started taking it. No side effects so far as I can tell. If anything there’s been a very subtle mood boost.

Want to experiment with higher doses, but would monitor serum K+ more closely if I end up doing so. It’s only one anecdote but Reddit user OutrageousBit2164 says “I take 80mg daily but when I ramp up to 160mg there is clearly antidepressant effect, more vivid colors, anti anhedonic effect, music sounds better”

2 Likes