I had a stress test, the kind where you see your beating heart on a screen. After 25 years on a low carb diet, my scan showed that I had ZERO plaque in my heart and arteries. The cardiologist was amazed. I asked what this meant for my risk of a heart attack or stroke, and he said, “it is Zero.” (My diet is basically no sugar, high natural fat, and no vegetable oils.)
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Great news for you and I hope it’s accurate!
I had a nuclear stress test 4 years ago and had not heard they could see all the hard and soft plaque. I do question if that’s true, but I’m sure someone who knows more will chime in.
I hope to be wrong because they were not worried about me after my test. They did see some of my plaque, but I also have a lot.
That’s awesome, and it’s reassuring to have a happy cardiologist! However, unless you have an identical twin who had an identical lifestyle but ate a different diet, it’s impossible to say that your diet is responsible for that great result. Some people build plaque like crazy and die of MI at 50 with LDL-C of 100mg/dl. Others seem to accumulate very little plaque with LDL-C of 250mg/dl. However, that is on an individual basis. For the population, the overwhelming probability is that a person with LDL-C of 250 builds faster than the person with LDL-C of 100.
Either way, if your diet works for you and you’re in good health, nothing wrong in continuing it IMO.
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Dr. Brad’s BP journey. He has familial high BP of 140-150.
He used an ARB (Candesartan) and Empagliflozin to reach his target of 120 SBP. He also discusses his lipid lowering meds and how he got his LDL below 50 with Ezetemibe and Pravastatin.
Pro tip: Statins are best taken at night before bed.
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Interesting … Telmisartan is approved in New Zealand, but it isn’t funded by Pharmac (NZ’s pharmaceutical buying agency) turned down the application. I suspect it might be hard to get any and maybe that is why he has opted for Candesartan?
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Re taking at night it depends on the statin. For something with a longer half life like rosuvastatin it doesn’t seem to matter when you take it
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Dr. Brad’s take on Glycine. He takes it.
Short video on benefits below.
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I just learned I should take it in the evening… thank you.
Weight loss drugs help against dementia.
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Dr. Brad weighs in on protein intake.
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@A_User you might have already found what you were looking for, but I remembered you asked where I saw Attia mention his protein advice of 2.2kg per kg. There is a quick snippet of him saying this in the short YouTube Destrider just posted.
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Related to Stanfield, weren’t the results of that Rapamycin with old people exercising study supposed to be out by now? He had the results back in June or July.
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It takes a while. However the results were positive as Dr. Brad is going to get his PhD in Rapamycin.
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Positive how? He sort of alluded to there being a significant difference between groups, but the groups weren’t unblinded yet. However, if the study was about exercise and Rapamycin, a difference means Rapamycin was detrimental vs control, or was beneficial vs control. If Rapamycin doesn’t affect exercise, there’s no significant difference to report.
I can’t see how a literal growth pathway inhibitor could be beneficial during exercise, so I’d have to assume it was detrimental. (Though I will of course love to be wrong)
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He says the results from the Rapamycin trial are available and anyone who is at the conference could talk to him and he’d tell them the results. Not sure why he didn’t talk about it in the video.
His top interventions:
- SGLT2IS
- Rapamycin
- GLP-1s
- PCSK9 drugs
Then he goes into skin aging at 13:30.
Also Matt Kaeberlein also probably knows the results. Can anyone reach out to either of these guys to get the results? @mkaeberlein care to share here or by DM?
Dr. Brad’s state of the union address on longevity. The first part is about criticizing resveratrol, so just skip that. He also criticizes Fisetin.
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The paper is under review right now and I don’t think Brad wants to talk publicly about the results until it’s in press. It’s his call, and I’m going ot respect his wishes. I will of course give my interpretation of the results once the paper is out. Brad and I sat down for a longer interview at the same conference, which should be out on the Optispan Podcast page soon. Podcast — Optispan
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Thanks, Matt! Truly appreciate your opinion and stance. We’ll all just have to wait patiently and of course watch your videos! 
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Odd presentation. How do glp-1RA and pcsk9i fit into being longevity drugs? As far as I know neither have been tested as such. And the literature on pleiotropic effects of pcsk9i is pretty sparse. Apart from the generally salutary effects of lowering LDL, what’s the longevity benefit for non-CVD people?
A lot of work went into the drawn out rocket analogy for a modest payoff and Dr. Brad seemed very nervous. I confess I couldn’t get up any curiosity to watch the skin care fragment, so maybe that was stellar.
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