Ah yes, I have a glass of lemon juice with L-citrulline on average once every two days, perhaps 5 grams dosing.
Not sure how big of an impact that would have a day later… Gemini tells me:
L-citrulline is a non-essential amino acid with a short elimination half-life of approximately 60 minutes. It effectively lowers blood pressure (BP)—specifically reducing systolic BP by about 4 mmHg
I’ve been taking 1.5g. I saw @DeStrider also mention lemon juice, so I’m now adding my powders to lemon Spindrift and it’s great. (Just too lazy to squeeze lemons all the time!)
I just did a search asking if BP benefits only last those few hours and AI said it can last weeks to months:
Daily dosing of L-citrulline will likely provide sustained blood pressure reductions around the clock rather than just a few hours, based on studies showing modest but consistent lowering of systolic (∼4 mmHg) and diastolic (∼2 mmHg) BP with chronic use. This comes from meta-analyses and trials measuring resting BP after weeks of daily supplementation (3–9 g/day, 1–17 weeks), where effects reflect average levels over the dosing interval, not just peaks.
L-citrulline has a short plasma half-life (∼1–4 hours depending on dose/population), with peak arginine/NO effects 1–2 hours post-dose fading by 5–8 hours. However, daily dosing builds cumulative vascular adaptations—like better endothelial function, reduced arterial stiffness, and NO bioavailability—that persist beyond acute peaks, as seen in 24-hour ambulatory monitoring and trough measurements (e.g., morning BP after evening dose). Once-daily morning intake should cover you well, though splitting doses (e.g., 3–6 g AM/PM) might smooth levels more if using ≥6 g total for diastolic effects.
Yes, the L-citrulline plays into it as well.
Not too sure about Citrulline
Since there is not enough information available in that paper, I can’t say it’s bs. But you can check for yourself. Take your blood pressure then take 3 grams of citrulline and check your blood pressure an hour later. From previous papers, the effective dose starts at 3 grams. At 3 grams and above it works.
A good overview from WaPo:
Hypertension can affect your mind, heart, eyes and more, often without causing any obvious symptoms at all.
Nearly half of adults in the United States have hypertension, or high blood pressure — but many of them, an estimated 11 million people, don’t know it. The condition is a leading cause of preventable death, increasing the risk of heart disease, kidney disease and stroke. “When we think about preventable diseases, hypertension is one of the greatest because it affects so many organs,” said Tamar Polonsky, a cardiologist and director of preventative cardiology at the University of Chicago Medicine.
Luckily, with medication, “we can get almost the majority of people down to a very reasonable blood pressure,” said John Bisognano, a cardiologist at the University of Michigan Health Frankel Cardiovascular Center. The challenge is that hypertension is silent — there are often no symptoms until the condition has triggered other health problems — so regular blood pressure checks are essential. “There are so many people who have hypertension and don’t know,” Polonsky said.
Left unchecked, here’s how blood pressure quietly damages the arteries — and eventually organs throughout the body.
Full story: What high blood pressure does to your body (WaPo)
What else are you doing?
And high blood pressure is caused by…
Arterial plaque caused by High cholesterol.
So what’s the difference between the high blood pressure and high cholesterol categories???
Is it that chronic High BP is caused by plaque or plaque caused by High BP? (or both).
I always thought it was the plaque reducing the diameter of the arteries which then increases blood pressure. But it is a self-reinforcing negative cycle as each begets the other.
I don’t know what the research says. My own experience has quite volatile blood pressure because when I apply a systemic change to mitochondria the homestatic feedback system in the cardiovascular system needs to adjust and that does not happen instantenously.
Also the vasodilation that occurs with drinking reduces arterial blood pressure quite substantially and this also then causes the homeostatic feedback system to adjust whilst the acetate is systemic and then it has to readjust when the acetate has gone (in around 2 days).
I would think, therefore, it is not the reduction of the diameter that matters so much, but the reduction in elasticity. I do think this will have an effect, but also higher BP can cause further endothelial problems.
I would be interested in reading any papers on this.
My N=1 is a decade ago, I had a CAC of almost 500, so it’s sure to be higher now, and I have good blood pressure.
Perhaps this means I have plaque but decent elasticity?
That may be true.
Here is a list of the causes of high blood pressure:
Essential hypertension (comprising 90–95% of clinical cases) does not have a singular biological cause. It is a polygenic, multifactorial syndrome driven by the dysregulation of interacting neurohormonal, vascular, and renal systems. Secondary hypertension (5–10% of cases) has discrete, identifiable etiologies, such as primary aldosteronism, pheochromocytoma, or renal artery stenosis.
Current clinical and scientific evidence identifies several primary, interacting biological drivers in essential hypertension:
Endothelial Dysfunction and eNOS Uncoupling: The healthy endothelium regulates vascular tone via the production of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS). In hypertension, elevated oxidative stress (reactive oxygen species, ROS) depletes tetrahydrobiopterin (BH4), a crucial eNOS cofactor. This leads to eNOS uncoupling, where the enzyme produces superoxide instead of NO, creating a pro-inflammatory, pro-thrombotic, and vasoconstrictive state.
Renin-Angiotensin-Aldosterone System (RAAS) Overactivation: Chronic upregulation of the RAAS pathway leads to excessive Angiotensin II production. Angiotensin II is a potent vasoconstrictor that also stimulates aldosterone secretion (driving renal sodium and water retention) and activates NADPH oxidase, further exacerbating oxidative stress and endothelial dysfunction.
Sympathetic Nervous System (SNS) Hyperactivity: A disturbed basal sympathetic tone, originating in the hypothalamus and influenced by cortical signaling, drives elevated resting peripheral resistance and cardiac output.This is often the most consistently observed abnormality in the early development of essential hypertension.
Vascular Remodeling and Arterial Stiffness: Chronic mechanical stress and low-grade systemic inflammation lead to structural changes in resistance arteries. This includes vascular smooth muscle cell (VSMC) hypertrophy, extracellular matrix (ECM) alteration (collagen deposition, elastin degradation), and increased vascular stiffness, which creates a positive feedback loop sustaining high blood pressure.
Chronic hypertension accelerates biological aging by inducing vascular cellular senescence, driving mitochondrial dysfunction in VSMCs, and precipitating end-organ damage (renal failure, cognitive decline, cardiac hypertrophy). Intervening in these specific biological pathways is critical for extending human healthspan and lifespan.
Targeted molecular interventions include:
Thanks @RapAdmin I’m thankful that the longevity interventions I’ve adopted have brought my SBP down from 120-130 to 100-110. Any further reduction is dangerous (risk of passing out) IMHO (and based on personal experience!)
Methotrexate has been a staple treatment for rheumatoid arthritis for decades, valued for its ability to calm an overactive immune system and reduce painful joint inflammation. Now, researchers say it may deliver an unexpected bonus that matters far beyond the joints: lower blood pressure, a change that could translate into meaningful protection against heart attacks and strokes for some patients.
https://scitechdaily.com/common-arthritis-drug-found-to-lower-blood-pressure-and-boost-heart-health/
Yeah, the issue is, if your taking everything, from telmisartan, to glps, to jardiance, to statins, high dose glycine, high dose melatonin (I think I read somewhere that melatonin, my favorite molecule, which actually counteracts certain bp meds, may actually be modulatory which I hope is true), to whatever could possibly lower your bp, and your stack is thick both with prescription and supplements, its hard not to get down to that level…
For me when I wake up I’m there in the 90s/60s (which seems to be my lowest bp reading in a day).
The obvious answer is to cut back the telmisartan, but I have a light CKD 2 disease and its recommended for that, as well as the fact that its highly sedative (for me, telmisartan 80 is highly sedative though I see no one else mentioning this), and it helps me sleep and getting off it would dysregulate that for a bit im sure. As well as the fact that there is more literature for the longevity of high dose telmisartan potentially
Don’t know what to cut off really…
The things I’ve passingly read is hypotension is at issue when you start having side effects like dizziness, and that some healthy athletes function with hypotension, so I’m kind of hoping the lower the better if there are no issues, but thats not a streamlined thought.
I think if you are feeling sleepy from the BP meds, it could be due to the low BP caused by those meds. I feel sleepy when my BP gets too low as well. It may not be a good thing.
Not sure thats it, as, at least for me, my bp is highest at night before bed (maybe as the telmisartan wears off for the day) when I take the telmisartan and it takes a few/several hours for the telmisartan to start lowering my bp significantly, while the sedating affect is immediate. But, from a cursory look on the internet maybe it isn’t a typical side affect…Maybe my biology?