Of Mice and Men Aging: Crucial Differences for Old Men

The graphs of the 9 and 16 month old mice starting rapamycin and acarbose (see below) are full of interesting features. 1.) obviously, the extended life span in the end, prolonging beyond 1200 days. 2.), which could have been present without the first (!), especially for the 9 month old females, the onset of the dying is delayed right away, meaning those that would have otherwise soon died already, did not. This underlines that live-extension is not about the future and getting very old, but being healthy now, in a year from now, and so on. 3.) As with humans, looking at the males, they start dying so much earlier, so blame mainly testosterone, not society. HOWEVER, 5.) …, well let me first mention another, 4.) when the 9 month old males start rapamycine, the untreated group apparently got the advantage, so this reminds us to be always guarding against reading too much into a few sets of empirical data. But one thing is clear, 5.) while already older male mice got as old as the females, this is for us humans very different. Why? In point 3, you can blame testosterone rather than social structures, but I have argued such to be invalid in the case of us human older males dying so early, see "Hyper-Aged Men Finished Off by Ageism and Misandry: from Deadly Discrimination of Men in Society, Social Science, and Andragogy Practice, Toward … " (2016).

[I do not spam my papers anywhere, but on this forum there surely are people interested in the details of why we croach so early, the differences in such graphs between males and females dying and suchlike, and you cannot find such unbiased scientific discussions easily, because anything even just potentially perceived as “pro male” is almost impossible to publish academically - that is why this article is on the vixra preprint server rather than on arxiv or in a high impact factor journal like most of my other scientific articles that are at the same or at times sadly even less rigourously scientific level.] I wonder what people here think about these issues, and if not so fitting, I apologize, and perhaps you can even tell me where else this might find a more receptable audience today - my field is mostly physics, so I really do not know. Thank you in advance for your comments.

The graph (You can find it and the source article easily already discussed on this forum if you search for rapa and acarbose together):

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I think you make some very valid points and it’s great to have another intellectual on this site. Please feel free to share your views here without worry as to what others may think.

After all, we’re in this together to help each other live longer. :slight_smile:

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