On the rejuvenation olympics panel, people are ordered by rate of aging irregardless of the age but the average rate of aging does depend on the age.
For instance the average rate of aging at 20 is 0.836 so, for a 20 yo, a DunedinPace of 0.85 would be bad (worse than the average) while it would be good for a 60yo.
To be able to compare the rate of aging between people of different ages we can normalize the rate of aging to some fixed age like 60.
This is what I did in the table below that gives the rate of aging normalized to an age of 60.
For instance B.J is 46 yo and has a best rate of aging of 0.64 and if we look at the closest table entry 45/0.65 we get 0.68. That difference does not look very large but it’s enough to have him rank around 20 places lower.
Age
0.40
0.45
0.50
0.55
0.60
0.65
0.70
0.75
0.80
0.85
0.90
0.95
1.00
20
0.45
0.50
0.56
0.61
0.67
0.73
0.78
0.84
0.89
0.95
1.00
1.06
1.12
25
0.44
0.49
0.55
0.60
0.66
0.71
0.77
0.82
0.88
0.93
0.99
1.04
1.10
30
0.43
0.49
0.54
0.60
0.65
0.70
0.76
0.81
0.87
0.92
0.98
1.03
1.08
35
0.43
0.48
0.53
0.59
0.64
0.69
0.75
0.80
0.86
0.91
0.96
1.02
1.07
40
0.42
0.47
0.53
0.58
0.63
0.69
0.74
0.79
0.84
0.90
0.95
1.00
1.05
45
0.42
0.47
0.52
0.57
0.62
0.68
0.73
0.78
0.83
0.88
0.94
0.99
1.04
50
0.41
0.46
0.51
0.56
0.62
0.67
0.72
0.77
0.82
0.87
0.92
0.98
1.03
55
0.41
0.46
0.51
0.56
0.61
0.66
0.71
0.76
0.81
0.86
0.91
0.96
1.01
60
0.40
0.45
0.50
0.55
0.60
0.65
0.70
0.75
0.80
0.85
0.90
0.95
1.00
65
0.39
0.44
0.49
0.54
0.59
0.64
0.69
0.74
0.79
0.84
0.89
0.94
0.99
70
0.39
0.44
0.49
0.54
0.58
0.63
0.68
0.73
0.78
0.83
0.88
0.93
0.97
75
0.39
0.43
0.48
0.53
0.58
0.63
0.67
0.72
0.77
0.82
0.87
0.91
0.96
80
0.38
0.43
0.48
0.52
0.57
0.62
0.67
0.71
0.76
0.81
0.86
0.90
0.95
85
0.38
0.42
0.47
0.52
0.56
0.61
0.66
0.70
0.75
0.80
0.85
0.89
0.94
90
0.37
0.42
0.46
0.51
0.56
0.60
0.65
0.70
0.74
0.79
0.84
0.88
0.93
95
0.37
0.41
0.46
0.50
0.55
0.60
0.64
0.69
0.73
0.78
0.83
0.87
0.92
100
0.36
0.41
0.45
0.50
0.54
0.59
0.63
0.68
0.72
0.77
0.82
0.86
0.91
For those interested in the details, the average by age is: Age * 0.0024131 + 0.787993
The DunedinPace normalized to 60yo is: DunedinPace * 0.932779 / (Age * 0.0024131 + 0.787993)
This is exactly what I’ve been wondering about!! My initial thought on this was related to the 12 Hallmarks of Aging and if it was easier to affect those for a younger person than an older person.
Your analysis is pretty interesting.
My wife Joan Matheson is 67 and her best Pace is 0.74 avg 0.84 She was ranked at # 16 but has dropped to 25 on the leader board.
I’m (age 68) ranked # 63 at the moment with a best Pace of 0.94 avg 1.01
It looks like the normalization would not change either her or my result.
Is this an established fact? I’ve not looked into this. Have you seen any references/papers that demonstrate this, or is this your theory and calculation based on the results available in this cohort?
You don’t know because the others are not normalized. I took B.J as an example because we know his age.
BTW as I normalized to 60, people 60 or close will see no or only a small adjustment.
If the people just before your wife in the ranking are younger than her, they will have a worse adjusted pace while she will have a better one.
For instance I just googled for Andrea Kladar which is just above your wife and I found one who is a 45yo runner. Assuming she is that woman, her average pace would be adjusted to 0.86 and she would be behind your wife.
This a useful analysis. I found that as my epigenetic age went down the pace of aging went up. That raised some interesting questions. In the end I am concentrating on getting my functional biomakers improved (which includes things like individual hairs moving from being vellus through to terminal and from white to pigmented)
Hence particularly as Trudiagnostic seem to have put prices up quite a bit (through levies for international travel) I have stopped doing their tests.
The prices look the same for the US - $229 USD for DunedinPace. Have you quit doing any Epigenetic Age testing? Then, besides your weekly blood tests, what do you consider your most useful tests? I’m following your blog, so I’ve seen your post on Epigenetic Age Changes, and the one on fingernails.
You mention functional tests, like hair, and I think I’ve seen you reference the sit-to stand chair test and standing up from sitting on the floor without using your hands. Anyone special insights about testing?
As some find this not intuitive, I’m presenting that as a conversion table to normalize the DunedinPace of aging between different ages.
For instance if we want to compare Dave Pascoe (62) to Bryan Johnson (46) we can normalize BJ’s rate from 46 to 62. For that in the battle below we take the line with age 45 and column 60 and we get 1.04 so we multiply the rate 0.64 by 1.04 and we get 0.67 which is less good than DP who has 0.66
Alternatively we could normalize DP’s rate from 62 to 46 by looking up the starting age (60) in the lines then the target age in the columns (45) and we get 0.96.
Multiplying DP’s rate of 0.66 by 0.96 we get 0.63 which is better than BJ’s 0.64.
So either way DP’s rate of aging is better than BJ’s one when compensated for age.
WIth shipping and taxes it is USD 412.38 per test.
I do quite a few tests other than the weekly blood tests although many are just running a fitbit, doing blood pressure and measuring weight. Observing phenotypic changes are perhaps the most important.
I don’t think there is enough reliable meaning in the epigenetic tests as yet.
Thanks! I’m just doing a final rundown of testing for my baseline before starting rapamycin and acarbose. I have my Polar H10 and getting a sleep score and EliteHRV in the morning, also cardiovascular workout, blood pressure and DexaScan. And grip strength, will do the sit to stand and box jump.
After reading Wikipedia and specially this-
" He was beaten into fourth place by the “Silly Party” candidate – the pet dog of the master of St Catherine’s College, Oxford."
I just wondered…is that when you started drinking? Or was it the notorious catnapping incident or missing out on the golden rodent?
With my cynical attitude, I’d say that about life itself.
My conversation with god goes something like this…“you’re going to throw us out into the cold with no blanket?”…God - “No blanket…but here’s alcohol.”
Or my favorite Flannery O’Connor quote:
“Later he saw Jesus move from tree to tree in the back of his mind, a wild ragged figure motioning him to turn around and come off into the dark where he might be walking on the water and not know it and then suddenly know it and drown.”
TruDiagnostic explicitly says: now ranking by PACE of aging alone for the PACE leaderboard so the other guy should be above you.
Maybe they have not updated the web site though.
