Bryan Johnson, Is he the New Poster Child for Rapamycin Use?

My wife and I are not super diet oriented. She is # 16 on the leader board, I will be much further down when my data gets added.

We do try to avoid processed foods and unnecessary carbs but we are both dedicated meat eaters :slight_smile: fish, chicken, pork, lamb, beef. We eat fruit and veggies, some dairy products, cheese, grass fed butter, yogurt, ice cream once a week or so. Some fermented foods like sauerkraut as you can see, not much of a focus on diet.

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The data used is the DunedinPace results from a Trudiagnostic test. To get a blue check you need to have at least 3 tests within 2 years. You can enter with only 1 test but you won’t get the blue check and probably won’t be in the top tier of participants until you have done enough tests to be statistically relevant.

You do not submit your own data, you submit a bar code that is issued for one of your tests and the leader board is populated by direct access to your results so there is no fudging of the data by any of the participants.

You will see 2 results for each participant with a blue check, an average of the last 3 tests and your best test result.

Since Joan’s results have been improving the last 3 tests, if her next test is as good as or better than the last one, she may move up the leader board :slight_smile: end of September we should see her new data.

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And I’d like to know their age. Simm Land the leader is 29 (correction from ng0rge), Bryan J is 46, most who are ahead of Joan are younger. Theoretically it should be easier to score higher (in the RO rankings) the younger you are, with similar interventions. A questionable assumption by me :slight_smile:

Fewer of the 12 Hallmarks of Aging would be at play for a 30 y/o vs a 67 y/o.

Anyone want to contribute ages they find, let me know and I’ll add to the list :slight_smile:

Simm Land - 29
Ben Greenfield - 43
Bryan Johnson - 46
Dave Pascoe - 62

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Reddit says “Dave Pascoe is 62 and ages slower than Bryan. Then there is 29 year old Siim Land.”( and Siim Land says in his video 6 weeks ago, he’s 28).

But, interesting point on whether younger age gives you an advantage…just based on DunedinPace rate of aging score, I assume it’s adjusted for chronological age. Otherwise your rate of aging would be expected to increase with the build up of cellular damage and breakdown of homeostasis. But as you point out, it may be easier to slow your rate of aging with interventions when you are younger and your body is more responsive. Are there scientific studies that show this? Most ages for the leaderboard are probably out there, I just haven’t searched them all.

Edit: Here’s 2 more - Julie Gibson Clark, 55 and Amy Hardison, 64 (as of 5/21/2024)
https://www.foxnews.com/health/three-women-share-secrets-better-health-longevity

And, of course, Michael Lustgarten, 51 and John Hemming, 64.

This says that Jenvel Earth is 29 - Jenvel Earth's longevity blueprint: reversing ageing at 29 with a biological age of 21

And here’s an interesting one - Tiat Lim at #10 - this says he’s 52.
https://www.deaging.guru/
And here’s his very entertaining challenge to Bryan Johnson:
https://1drv.ms/b/s!AuCajgI7C6hDl6Vp7R7uCsmBTsK9QQ?e=3Yrtm6

And an article covering the whole top 10:
https://www.sanatorium.health/july-2024-analyzing-top-10-longevity-leaders-common-habits

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His words ring so true.

I’ve always loved myself. But societal structures and pressures (office politics) pose the biggest threat to my happiness.

I disagree with Bryan about divorce. I am a much happier man thanks to my wife and sons.

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You can have a look at : Normalizing the TruDiagnostic DunedinPace rate of aging by age

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Yes, I’ve been following that thread but not sure I understand the chart. For Bryan Johnson, on the chart using the closest numbers, you get .68. Now, what does .68 represent - compared to his rate of aging, .64?
What do the numbers across the top of the chart represent?

I posted another way of looking at the age compensation/normalization in the original thread: Normalizing the TruDiagnostic DunedinPace rate of aging by age - #8 by cl-user

Tell me if it’s more understandable.
Anyway when compensated for age Dave Pascoe has a better rate of aging than Bryan Johnson and Simm Land is third.

BTW I think TruDiagnostics should normalize by age otherwise most of the top ranks will be taken by people in there 20’s.

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It’s hard to believe that they wouldn’t normalize by age as part of their algorythm. Has TruDiagnostics confirmed that your analysis is correct?

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I’m using their data below. If they were normalizing by age, the best fit line would be horizontal.
image

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I certainly don’t want to be critical but I’ve been following him for a while I have observed some facial work he has done (layers and facial injections aka :wink: natural) in addition to his new set of pearly white teeth he does look pretty good, but so do many of my friends who have had many of the same procedures. IMHO-He may be turning back the Clock internally but externally it’s mostly superficial. Of course this is my opinion I could be wrong it’s more of an observation.

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Agree. More power to him and I do stuff to my outsides too, but in a perfect world, it would be great for us to see his untouched outsides in order to observe how much becoming healthy on the inside translates to appearance. I am a fan of his and love what he is doing, but for the reasons you’ve mentioned, how he looks is meaningless to me. I’m not throwing shade because I wouldn’t be willing to do that either!

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I agree with your observations. I also think that all superficial alterations to his face/body are wrong on his part and deceiving for those who follow him bc ppl want to see how his anti-aging protocol makes their appearance youthful from within. And if it did it could be a proof that what he’s doing works. Unfortunately we’ll never know that. We have to take his word for it. This is what I don’t like about him.

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To be fair to Bryan, he’s trying to be and look as young as possible, and there isn’t a treatment out there that can materially reverse facial aging. But, it stands to reason he’s had multiple treatments. He’s said quite a few times that skin is really hard, and it’s definitely harder if you don’t look after yourself. You only have to look at the difference between men and women. Most men don’t care about skincare, but lots of women do, and look younger for longer. For some reason, I think we get fixated on appearance, but it’s just not feasible to expect Bryan to physically age backwards without help or that he should leave his face just so few can see 'How he looks". He wants to be as young on the inside as he does on the outside, it’s just really hard. In his defense, he’s logged every treatment he’s done, it’s all on his website. Personally, I think he looks great all things considered. He’s never really going to look 18 again, but he is showing what’s possible.

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Skin is only hard because you have to actually improve the functioning of the cells in the skin.

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I thought this was particularly interesting. I’ve noticed that people who have severe infections tend to rapidly lose collagen, I assume there’s a link between immune dysregulation and skin aging.

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I think the Extra Cellular Matrix is probably quite sensitive to cellular power levels (the amounts of acetyl-CoA in the cytosol/nucleus).

Hence when cells go senescent the ECM also is not built properly.

I have updated my poster web page following my blood test on Wednesday
https://citrate.science/2024poster/poster.html

Where it shows the effect of varying levels of acetyl-CoA on the speed of repair of a venepuncture (because I have a venepuncture each week I can compare different exogenous cellular environments).

Interestingly you have a venepuncture on 26/7, 31/7 and 7/8. The later two had reasonably high citrate dosing before the venepuncture and that of 26/7 only had citrate after the venepuncture.

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The lady pictured looks like she’s doing great for 55 but me thinks our own @LaraPo blows her out of the water on appearances. I’m fairly new to the longevity space but basically look the same as her at 54 fwiw. Excuse the ignorant question but are the Rejuvenation Olympics ongoing?

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Think so

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Yes and I expect that will continue for quite a while. It’s a great marketing tool for Trudgnostic / Blueprint and any of the participants that list a “clinic”.

Unfortunately those of us doing this on our own are lumped into the “TruDiagnostic House Clinic” category.

We entered just over a month ago, there were about 500 participants. Yesterday I checked and there are now over 1,100 participants. I expect the “kardashian effect” will add significantly to the growth.

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