how frequently should rapamycin be applied orally (with toothpaste/tray gel) once per week or daily?
are there any instructions for how to formulate the gel/paste?
can you use the sirolimus powder and remove it from the capsule?
is there any more economical source which is trustworthy?
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I treat it the same way they treat the topical rapamycin cream for skin - I use it every time I brush my teeth, so typically 2 times a day.
But that said, this is still a research project so the optimal dosing isn’t yet determined.
Full details on how to make your own Rapamycin Toothpaste are here: DIY Rapamycin Toothpaste and Flossing Paste
Most of us just use the crushed pills, but you can easily use the rapamycin powder if you can get a good source.
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Thanks. I have been taking rapamycin orally once per week for over a year and personally have seen significant oral improvements with respect to gum health, inflammation, gingivitis, etc. That has been the most notable benefit, along with reduced shoulder pain.
Now i am considering adding to my regime the toothpaste in addition to the weekly oral capsule.
I am surprised it should be applied daily in toothpaste, Can you clarify why the dosing schedule is daily when used as toothbrush but weekly or biweekly when taken orally for for longevity.
It sounds counterintuitive, since I understand the rationale for pulsing mTor and taking rapamycin once per week to avoid constantly supressing mTor. The research shows that daily is not recommended when taking rapamycin orally. Why is it different when used topically as toothpaste/skin? Is this because the absorption is reduced when applied topically or some other reason?
Update i see in the link below it’s mentioned that when using toothpaste it’s not taken up into the bloodstream. So that would explain why daily application would not be supressing mTor. But then through what mechanism does topical application have any effect on improving skin/oral health, reducing bone loss?
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Its much lower dose in the topical application. Here are the details on the topical skin use of rapamycin: Rapamycin May Slow Skin Aging (Drexel U. Study)
We don’t know the optimal dosing regimen for rapamycin in any longevity / anti-aging application, so its all basically trial and error right now. See what works for you, test if possible, track results, and modify as needed.
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This seems to provide a link to the anti-inflammatory benefits of rapamycin and its apparent positive improvements in periodontal disease:
Periodontal disease as a model to study chronic inflammation in aging
Periodontal disease is a chronic inflammatory condition that results in the destruction of the teeth supporting tissues, eventually leading to the loss of teeth and reduced quality of life. In severe cases, periodontal disease can limit proper nutritional intake, cause acute pain and infection, and cause a withdrawal from social situations due to esthetic and phonetic concerns. Similar to other chronic inflammatory conditions, periodontal disease increases in prevalence with age. Research into what drives periodontal disease pathogenesis in older adults is contributing to our general understanding of age-related chronic inflammation. This review will present periodontal disease as an age-related chronic inflammatory disease and as an effective geroscience model to study mechanisms of age-related inflammatory dysregulation. The current understanding of the cellular and molecular mechanisms that drive inflammatory dysregulation as a function of age will be discussed with a focus on the major pathogenic immune cells in periodontal disease, which include neutrophils, macrophages, and T cells. Research in the aging biology field has shown that the age-related changes in these immune cells result in the cells becoming less effective in the clearance of microbial pathogens, expansion of pathogenic subpopulations, or an increase in pro-inflammatory cytokine secretions. Such changes can be pathogenic and contribute to inflammatory dysregulation that is associated with a myriad of age-related disease including periodontal disease. An improved understanding is needed to develop better interventions that target the molecules or pathways that are perturbed with age in order to improve treatment of chronic inflammatory conditions, including periodontal disease, in older adult populations.
(Paywalled paper)
Related Reading:
Periodontitis and Accelerated Biological Aging: A Geroscience Approach
Growing meta-epidemiological data implicate chronic systemic inflammation/infection due to periodontitis as an independent risk factor for aging-related diseases and mortality.
https://journals.sagepub.com/doi/abs/10.1177/00220345211037977?journalCode=jdrb
and
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I need to make a second batch of toothpaste. My dentist and hygienist commented on how wonderful my teeth look. 5-10 years ago I used to get dark warnings about receding gums.
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Nearly half of U.S. adults over 30 show signs of gum disease, which can cause tooth loss. Here’s how to recognize and treat it.
If your spit is sometimes tinged pink at least a couple of times a week after you brush or floss, it’s possible you have early-stage gum disease. But the troublesome condition can also have other surprising symptoms — or none at all.
“It’s a very, very quiet disease,” said Dr. Rodrigo Neiva, chairman of periodontics at Penn Dental Medicine.
According to the U.S. Centers for Disease Control and Prevention, nearly half of U.S. adults over the age of 30 show signs of gum disease, and nine percent have severe gum disease, known as periodontal disease.
When left untreated, gum disease can become more difficult to remedy. “Patients may eventually end up losing their teeth,” Dr. Neiva said. And some research has connected periodontal disease with other undesirable health conditions, such as dementia, diabetes and heart disease.
…
People who rarely get cavities may be more likely than other people to get gum disease, too, Dr. Neiva said. That’s because the bacteria that cause gum disease outcompete and suppress the bacteria that cause cavities.
“It’s very common to see patients with very, very advanced periodontal disease not having a single cavity,” he said.
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