New Rapamycin podcast with Pankaj Kapahi

#1

New rapamycin podcast episode out :pray: In this episode of “Rapamycin Master Series” I interview the longevity researcher Pankaj Kapahi. He has his own lab at Buck Institute for Research on Aging and has done two decades of research in areas such as dietary restriction, fasting, rapamycin, nutrition and metabolism. Pankaj was one of the pioneer researchers who discovered in the beginning of 2000 that genetic inhibition of mTOR led to life extension in flies.

01:45 Pankaj’s longevity interest and calorie restriction
03:05 How Pankaj’s longevity research started
04:54 Activating the survival defense mode
06:38 The survival mode is a stress response
08:10 Difference between calorie and dietary restriction
09:22 Limiting calories preserves muscle mass
10:47 Biomarkers when guide us to avoid overdoing things
13:27 Genetic mTOR inhibition discovery in flies
16:29 Protein restriction as mTOR inhibitor
17:28 Is it possible to genetically inhibit mTOR late in life
18:34 Rapamycin vs genetic inhibition of mTOR
20:36 Weak points regarding Rapamycin
25:13 Pankaj’s Rapamycin usage
26:58 Daily vs weekly dosing
29:48 Side effects Pankaj has experienced with Rapamycin
29:51 Pankaj’s beneficial effects with Rapamycin
31:56 Pankaj’s risk and benefit calculation
34:15 Additives to Rapamycin
36:52 Fasting vs calorie restriction
39:01 GLYLO and Advanced Glycation End products (AGEs)
41:06 Combining Rapamycin and GLYLO
42:47 How GLYLO was discovered
46:31 Why don’t more people talk about AGEs
48:25 Diseases related to AGEs
51:30 ITP proposal to test GLYLO
53:03 Rapamycin + GLYLO vs Rapamycin + Acarbose
54:00 GLYLO is sold as a supplement
54:14 Pankaj’s dose regime of GLYLO
54:27 How Pankaj combine GLYLO and Rapamycin
55:22 Side effects Pankaj has experienced with GLYLO
56:29 Pankaj’s beneficial effects with GLYLO
57:52 Alternatives to reduce AGEs
1:02:19 Rapamycin and it’s effects on AGEs
1:03:48 What is the best dose regime of Rapamycin for longevity?
1:04:58 How well will Rapamycin work in humans?
1:06:09 Any additive effect with combining extended fasting with Rapamycin?

Links

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Big Review paper: Targeting ageing with rapamycin and its derivatives in humans (LancetLongevity)
New Rapamycin podcast with Matt Kaeberlein
#2

Interesting the dosage he takes is 1mg per day, and not the usual once-per week favoured by others.

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#3

Yes, its always interesting when someone is doing in different ways because it forces us to rethink who is more one the right path and not :pray: it can also be that there is not one way to achieve what we are all trying to achieve.

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#4

Excellent interview. He really gives good points. I did not manage to listen it before but I bookmarked it and I am really happy I did. He seems really knowledgable and down to earth to what extends life and healthspan… I really like his way of thinking, it is not one thing, but many things and it is quite individual but involves few basic principles. What and how much we eat, how much we exercise, how we hake care of our psychic wellbeing and additionally, can I add interventions that would help with the above. And I picked up that balance is really important in everything we do, even too much of a good thing becomes limiting in what we want to achieve. There are different (individual) paths to the same goal.

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#5

:+1: great to hear and a very good summary of key takeaways!

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#6

This was good. Better than expected due to his differing point of view on dosing. I need to look into the AGE issue more closely. Thanks for doing this!

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#7

As of Dec 22 2023, Glylo is offering 50% off at the company website.

Seems inexpensive at that price. I have no idea how long the code will work. I am not affiliated

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