New Peter Attia interview w/Matt Kaeberlein, inferior bioavailability of encapsulated rapa

Since I already have a large quantity of compounded capsules, I ordered some of the empty enteric coated capsules. I’ll fill one and place it in a glass of body temp water with some vinegar (don’t have access to HCl). Interested to see what the dissolution time will be. Not the best science, I know, but it’s a start. I’ll let you folks know.

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I think MAC already did this on another thread and said they dissolved way too fast

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A simple solution is to take an over the counter H2 blocker 90 minutes prior totaling rapa
Famotidine 20 mgs costs $ 0.35 per pill
This will suppress stomach acid temporarily an allow got improved absorption of rapa
Famotidine 20mgd is otc

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Interesting suggestion on this - have you tried it?

The famotidine is a good theory that I suggested on an earlier thread, but I don’t know of any data to prove it actually works to increase absorption of rapa capsules. Seems like one’s best bet, with minimal risk, if capsules are all you can get.

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Because I am also using compounded capsules, I’ve tried the experiment @Paul_Moss suggested. I put instant coffee in an enteric capsule (from Amazon) and placed the capsule in vinegar (held under the vinegar with a fork) to see how long it would take to spill the coffee. Stomach acid has a pH of 1-2, and 4% vinegar has a pH of ~2.3 (not quite stomach acid but close-ish). After about 2 hrs the instant coffee started leaking into the vinegar. The capsule starts disintegrating on the sharp edge where the larger half overlaps the other half capsule. (BTW, you can read about @MAC’s similar experiment, in the thread “Rapamycin enteric coating vs powder bioavailability”. I think he used delayed release capsules, not enteric, but check out his posts.)

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Thanks! Good to know.
And the instant coffee was a really good idea. Easy to visualize!

If taken on an empty stomach in the AM, then it seems like 2 hours ought to be enough time to clear the stomach in most people. I’ll repeat the experiment when my enteric acid resist capsules get here. That’ll take awhile though. Ordered from the US Ebay and I am in Japan.

I hope the enteric capsules and/or famotidine work, but due to the uncertainty I’m going to stick w/tablets. BTW the thing you would not want to do is to use both famotidine and enteric caps, since the enteric caps are made to only dissolve in higher pH, therefore increasing gastric pH w/famotidine would actually cause the caps to open up in the stomach. Maybe the rapa would still be absorbed due to the higher pH, but it would be a waste of enteric caps.

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So WHAT is the bioavailability of the dropship.md capsules?

Is anyone subscribed to the podcast willing to share some of his AMA’s?

Certainly not all so-called enteric capsules are equal. Seems like you found a good one.

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I subscribed to the Peter Attia membership then decided I’d cancel for a while due to the expense, after which they sent me an email with an offer that was dirt cheap, can’t remember exactly how much but it was just a fraction of the normal charge. I took them up on it. It might be illegal to share the podcast that is members-only, not sure.

@vegasallen1: The enteric capsules I used are just the ones from Amazon; I’m waiting to hear of other’s results doing this (or a similar) test. I have some of those that @MAC used (bought before I read of his experiment which soured me on them & I subsequently got the ones claiming to be enteric). I’ll try the same test with those as well.

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I performed this same test with the delayed release capsules (from Amazon) twice, and both times the coffee was spilled in under 55 minutes. In this instance, it’s more like the capsule itself dissolves; quite different from the behavior (described in an earlier post) with the enteric capsules.

What type is the dropshipmd.com capsules? It says film-coated (titanium dioxide)

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so we can see that there is nothing such as a pure pill

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Hello All - First time posting here. I am definitely concerned that I may not be getting rapa into my blood after hearing the new Peter Attia interview part on bioavailabilty. For about 1 year I have been taking a weekly dose of 4 MG of Biocon Rapacan with GFJ taken 4 hours prior. The description says the tablets are film coated but I am pretty this is not an enteric coating.

Wondering if anyone has tested blood levels after using this or a similar Indian bought supplement?

Also wondering if it might be easier to try to find a doctor that will prescribe the US made generic that has the enteric coating, though I know this will be more expensive.

Next step will be to try testing after a dose. Any input or advice is appreciated.

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Biocon and Zydus sirolimus are fine - lots of people have done blood tests to check their blood sirolimus levels and its definitely getting into the blood at good levels. I recommend you review this entire thread and you can see people reporting their results: Inexpensive Serum Blood Test for Rapamycin - #40 by Agetron

You may want to check, just to see how your body is responding: How to get a Rapamycin (sirolimus) Blood Level Test

All these drugs are usually being used by organ transplant patients. If they didn’t get the sirolimus into their blood, I think the patients would be very aware of it… the drugs (along with other drugs) help prevent organ rejection.

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Instead of 4 hours beforehand, maybe try 2. The multiplicative effect of grapefruit drops off quickly at the 4 hour mark. So the sweet spot is between 1-4 hours. After 4 hours, your body regenerates the enzymes and you get back to normal 1X absorption quite quickly. I try to aim for 2 hours to be in the “sweet spot” of maximum Rapamycin absorption.

And of course, your biology may be different. You could have a shorter sweet spot than most or longer. It’s hard to tell, so play on the safe side.

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Thank you for the info! I will view the threads you recommended.