more details below about how they extended mouse lifespan: Exogenous telomerase reverse transcriptase or follistatin genes increased telomere length and muscle mass, respectively.
https://www.pnas.org/doi/10.1073/pnas.2121499119
So is longevity all about hyperfunction inhibition, or do things like this matter for humans?
Note that 3 of the authors are from BioViva, and Bioviva gave grant money for this research.