I’ve just completed my first year on rapamycin and wanted to share my results. I’m posting my logs and blood test below.
A couple of takeaways:
I took rapa every other week.
Lipids - I saw no negative effects on lipids. I take 10mg rosuvastatin.
Glucose - No effect on HbA1C. It was more correlated to how often & hard I workout instead of rapa.
RBC, Platelets & Neutrophils - these all clearly improved while on rapa vs not.
I had two extended breaks during the year. Once in the spring with a gap of 2 months due to a surgery, and 2 months in the fall due to the flu. Sadly, I was just about to get my flu vaccine when catching it.
These are all encouraging results. No drift in lipids or glucose, and improvements in RBC, platelets, and Neutrophils. I hope to be more consistent this year.
Thank you. The rapa mg dosing is in the first column. I was taking 8mg, but was getting slight headaches, so I reduced to 7mg and for the most part have not had any headaches. No other symptoms.
Interesting, which brand of rapamycin did you take? I took Zydus 8mg 3 hours after meal and GFJ 2 weeks ago. My 84 hour blood test got a score of 13ng/mL. This week I took 4mg. Just had my 24 hour blood test. Next one will be at 72 hours.
I take Zydus. 8mg + GFJ will definitely increase your blood concentration. Since we don’t have any data on these super high doses I’ve just been doing it without GFJ.
It’s great that you’re tracking your markers longitudinally! I’d switch over to this spreadsheet, which has the added benefit of computing your levin phenotypic age.
Morgan Levine at Yale University (now she’s at Altos Labs) created what we call the Levine Phenotypic calculation. See this thread with links to the paper: A Friendly Biological Age Reduction Competition?
The latest result shows that I probably should reduce my rapamycin to 2mg + GFJ. Should give me more than 3ng/mL after day 3. And maybe move to a weekly or 10 day cycle instead of fortnightly.