Could someone get a PDF copy of the above linked paper and post/upload the copy?
The title is;
Posted link
https://www.nature.com/articles/s42255-022-00706-6
Thank you, Arhu
Now THIS is what we need more of… Data not anecdote.
One of the authors of the paper shared a link on twitter that allows you to view it (the full paper):
Let me know if this does not work:
Paper should be at this link below:
Thanks for taking the time to chart and share all this information!
That may be but it still does not make high TG levels ok.
The elevation of TG levels seems to be dose-dependent. It certainly seemed to in my case.
I think, because the majority of evidence indicates high TG levels are bad for your health, we should either adjust the dose or take other measures to keep TG levels in the “lab normal” range.
“Both fasting and nonfasting TG levels associate with CVD risk. In a European population, 27% of adults had nonfasting TGs greater than 176 mg/dL, a level that was associated with an approximately 1.9-fold increase in risk of CVD”
This has been discussed ad-nauseam in this thread, which I recommend people read if interested: Rapamycin and risk of cardiovascular disease
True, but it obviously unsettled. My main point of contention is: People taking rapamycin are using it to justify high lipid levels.
If you are taking statins, make sure you’re also taking CoQ10, since statins significantly reduce CoQ10 production, which is pretty important for healthy functioning.
My understanding is that people recommend it for muscle pain associated with statin use. I don’t have any muscle pain, and I regularly exercise, so should I still worry about coq10 ?
It’s way more than muscle weakness, it has to do with proper mitochondria functioning, which is basically the most important part that makes up “you”.
Here’s an research paper you can refer to: Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction - PMC
I was on statin after a myocardial infarction at 38yo, and the doctor didn’t tell me I had to top up on B12 and Q10 when on statin. Within months I started to develop the first depression I’ve ever had in my life, the contrast was huge since I’m generally a very optimistic and happy/content person.
It was later at a high-end health checkup clinic did the doctor there tell me Q10, B12, Omega 3 are definitely essential if you take statin. Especially Q10 since statins stops your body from creating them, which is pretty darn essential to your whole body’s proper mitochondrial functioning.
After some research, it appeared to me how bat shit crazy it is for a doctor to prescribe statin but not Q10, but then again it’s what the insurance companies approve (or deem as necessary) as insured meds, so if you understand how the system works you will know that you have to do your own research before eating any kind of prescribed meds.
Also, ApoB is the closest indicator of possible clogging in blood vessels, but inflammation is what causes endothelial walls to fill up with cholesterol and thicken.
Uric acid, CRP are some biomarkers to watch for.
Thanks! I’ll remember to monitor coq10 levels on my next panel. I probably haven’t felt a difference because I’ve been on statins less than 1 year
Thank you for sharing. Excellent blood results. I did have an increase in my basal glycemia for a few weeks too. (I wear a CGM). It is back to normal now.
FWIW…
Review link below.
“The world’s best and most comprehensive CoQ10 encyclopedia – the only place you need to go to find useful and practical information about the incredible substance Coenzyme Q10 commonly known as CoQ10.”
Thank you so much for sharing your journey thus far with us. Are you willing to share the price of using healthspan for both the Acarbose and rapamycin?
@qBx123Yk Thank you for sharing and nicely done! Just a few comments to throw away if not of value.
Some physicians in the hormone world do not like getting your total cholesterol below 140 since it is a building block for other hormones. I know that with certain high risk patients its worth the trade. It may be worth a discussion on adjusting your statin dose in the future.
3 month window changes could be due to some acute phase reactions that can start with new treatments vs. long term trends, but it should help clarify an urgency for immediate adjustment.
Your DEXA scan change may be in percentage error range? Just thinking to not read to much into it.
I am a fan of daily dosing of Vitamin D3 vs weekly dose of vitamin D2 as well as adding CO Q 10 to any statin use - but more a preference.
Thanks! I agree about the DEXA scan. I did gain some weight (confirmed by my personal scale), but the muscle and fat breakdown will have some error in it. The muscle breakdown in particular shows my left side being 2 pounds lighter than my right side. I’ve learned that it’s not uncommon for DEXA scans to show this discrepancy.
I heard about COQ10, but I feel great so far, and I really don’t want to add more to my supplement stack, if I can help it.
Hi Gus, I ended up paying $495 for 3 months of rapamycin at 6mg/week, and $90 for 3 months of acarbose at 25mg/day
Hi clammy 77, how are you feeling now after the myocardial infarction? You were talking about ApoB, was yours fairly high before the MRI? Has the Depression resolved since taking coenzyme Q 10? I have felt no depression from statins either, but I take 700 mg coenzyme Q 10 a day.
In short, I think much better than pre-MI, because I exercise a lot now, eat healthy, and I learned a lot to save myself so that resulted in just much better body hormonal balance and lifestyle. I’d say the MI saved my life.
I had another artery 50-60% clogged and I was able to clear it via exercising 30min/day, meditation 2 hrs a day (there was a study on this showing this could clear plaques), and various supplements targeting healthier heart and arteries (lumbrokinase, CoQ10, Ginko, fish oil, etc).
Depression was resolved when I stopped taking statins or lowered the dosage, and CoQ10 definitely helps too. I haven’t felt anything close to a depression since I lowered the dosage.
And in terms of ApoB, I actually don’t know, because hospitals aren’t insured to take ApoB tests. My LDL was at higher range I remember (130) but not like batshit crazy. I only took ApoB test recently and was around 73. My LDL is usually around 60 now. I eat like half a statin every Mon Wed Friday, with cholestoff, and red yeast rice.
From what I’ve studied, any atherosclerosis are mostly caused by inflammation caused by stress. Without inflammation, cholesterol doesn’t do much either, there are studies that demonstrate this. So the goal really is to regulate inflammation imo. Lower uric acid, crp, etc. The book “Drop Acid” is great.
PS: Also there are studies showing super low cholesterol doesn’t have any impact on health: EBBINGHAUS: No Effect on Neurocognition With Evolucumab - American College of Cardiology
Would love to hear if anyone has any insights on this study or claim. My cardiologist said that your body already has all the cholesterol it needs, the cholesterol we test for are just the circulating ones.
I haven’t looked at the study but at least in the short term there’s randomized controlled trials lowering to 20 mg/dl LDL median and there being no side effects, and decreasing events all the way down. That was the PCSK9 inhibitor studies. There is also one with statins, with a similar result. If I remember correctly there was one down to 7 mg/dl or extremely low levels. Circulating cholesterol levels doesn’t affect brain cholesterol, so unless the statins can pass the BBB and impact results they won’t, certain statins might have a lower chance to pass the BBB.