@Anthony Rosuvastatin is one of the statins that is not sensitive to GFJ so you don’t need to worry about dosage effects if that is the reason you plan to skip it on days your are experimenting with GFJ.
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I’m now favoring rosuvastatin over other statins for several reasons .
The lack of cyp3a4 effects, the potency, and lack of getting into the brain are excellent qualities. Also it is cheap.
On the downside . . A risk of T2DM and insulin resistance.
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Here is an excellent overview of GLP1, the hormone your body makes - and GLP1-R’s - the receptors which specifically interact with your GLP-1 and the “new” GLP1-RA (agonists) peptides that help this system work better.
https://www.nature.com/articles/s41392-024-01931-z
The linked study below, comprising a review of 23 RCTs and more than 150,000 patients - ONLY GLP-1 agents were associated with a SIGNIFICANT reduction - 45% vs those who received placebo in the incidence of dementia
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I’m sorry, Steve😭, but that’s just a terrible paper. It’s a case making review replete with mechanistic speculation, all piled up higgedly piggedly with studies from all over, animal data randomly with human and just a giant mess. I was wondering why the english was so poor (sample sentence: “These flaws create covertly.” - um, wha??), and why wasn’t this cleaned up, being in dire need of an editor. I looked it up - Indian + Saudi dodgy institutions; PASS. YMMV.
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There are 2 papers in my post, not sure which one you are referring to.
The first link is an overview of how the GLP1 system works in relation to GLP1-RA’s with a lot of good info for people who want to know how that works. There are more than a few misconceptions on GLP1 and GLP1-RA’s
The second one, I think my “headline” was from another article I read but I didn’t post that link, I posted another overview instead. So my headline is definitely misleading. in relation to the actual article I referenced.
This article is a review from 2022 of work completed by others in relation to potential dementia benefits.
Got you. Thanks for clarifying. The first paper I only glanced at, seemed fine.