My Dementia Protocol - Please improve it and offer advice

Here is my protocol right now for Dementia risk reduction, particularly on those with ApoE4’s.

Just like the post on take down my stack of supplements, I want community input on this on items I’ve missed or have wrong. This is the beauty of a community of smart motivated individuals. I can improve my protocols with you input, which will positively impact my patients.

Here it is:
Lifestyle options/labs/medications/supplements to risk mitigate for dementia

Lifestyle options

  • Use your brain to do complex things as much as possible. Passively watching things is fine for relaxation, but make your brain do repetitive hard work!
  • Diet with more veggies, pholyphenols, limited extra virgin olive oil likely good, fiber to >30-40 g/day
  • Limit or better eliminate artificial sweeteners
  • Minimize exposure to plastics – especially anything heated in plastic that you would then consume
  • No processed foods
  • Limit anticholingeric medications (for example Benadryl).
  • Limit or eliminate medications like benzodiazepines (Ativan, Xanax, Valium) or other similar (like Ambien)
  • Normalize hormones for life (some question on late introduction of estradiol in ApoE4 individuals)
  • Optimized blood pressure, insulin sensitivity and blood lipids (target to ApoB/Lp(a))
  • Optimize omega 3 index if ApoE4 positive then 10%, and vitamin D 70-90
  • Sleep monitoring to get at least 7 hours of sleep nightly, but not more than 9 hours
  • Regular aerobic exercise 150 minutes/week of zone 2, and 2 sessions of weight lifting (at least) weekly
  • Minimize alcohol and THC consumption
  • Don’t smoke cigarettes or THC (or anything else)
  • Optimize B12 (also measure MMA to confirm)

The Lancet article https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0/abstract discussed the following as risk factors, and if none were present 50% rate reduction of dementia:

  • Get more education
  • Avoid/Treat hearing loss
  • Avoid/Treat hypertension
  • Don’t smoke
  • Don’t be overweight or obese
  • Avoid depression, physical inactivity, Type 2 Diabetes, Excessive alcohol intake (>12 standard U.S. drinks/week), traumatic brain injury, air pollution and social isolation.

Tests to consider

Medications to consider:

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There’s some (weak) evidence for various curcumin formulas for neurodegenerative disease. If I was APOE4 positive, I’d probably take them just because they’re pretty low risk.

What do you think about cholinergics for prevention? Eg galantamine.

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Interesting - I don’t think it is disease modifying. I also feel the same with the phosphatidyl choline … once symptomatic, sure, but I don’t think it is disease modifying. Happy for the input as this is low evidence zone and I’m trying to give my patients with ApoE4’s the best.

It is great to have a community of seriously smart individuals who can provide input.

I’m holding off on doing my initial youtube video, as I have the channel DrApoE4, and will appreciate input from the community on what needs to be expanded or removed from my protocol.

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This is overall, an excellent list.

I would really focus on blood pressure… especially for those with ApoE4. Things like isometric training, a diet very low in sodium and high in potassium, at-home BP monitoring, etc.

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I agree - we have that in the protocol … goal sbp 115 mg

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Outstanding info.

The only details I’ll offer from my podcast guests relate to the BBB.

High BP damages kidneys and BBB. Lifestyle or drugs; get BP down.

Leaky gut issues lead to BBB issues. Fix the gut.

Also, I’ve read iron overload in tissues (vs blood) is implicated in dementia / PD.

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Oh man, this is a gigantic list! It would take months trying to digest this, but hey, we’re all vulnerable to some degree, you never know who might get struck, so it behooves everyone to chip in. The thing is, that so many of these are interconnected, dementias that are rooted in neurodegenerative diseases. I have long since thought that siloing dementia into a few distinct diseases makes little sense, they so bleed into each other, vascular, AD, LB and so on, addressing the etiology is going to be complicated. But since so many start decades before onset of symptoms, it’s never too early to start preventative measures. Thank you for generating this detailed post, and hopefully this will be an ongoing thread, that we can all contribute to, in the course of our own readings and research.

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Amy Proal in a Mike Lustgarten interview makes a compelling case for taking anti-virals preventatively for herpes related disease.

I take valacyclovir whenever I am run down or in the sun as a way to prevent herpes simplex virus. The association of herpes with dementia makes the use of antivirals a plausible addition to your medications list?

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Thank you Joseph - need to add ferritin - a critical item here.

This is the benefit of such a community that @RapAdmin has generated!

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I have a number of patients who are on daily valacyclovir for this exact reason.

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Hi @DrFraser! Thanks for sharing this well-aggregated information - great effort!
I’d like to draw your attention to riboflavin (Vitamin B2) and its potential influence on monoamine oxidase (MAO A) activity.

MAO A is crucial for breaking down serotonin, dopamine, and other activating neurotransmitters. Its activity varies genetically:

  • High-MAO-A: Faster neurotransmitter breakdown, potentially leading to lower mood or energy.
  • Low-MAO-A: Slower breakdown, which can cause overstimulation, irritability, or even mood swings.

So, what about B2? Vitamin B2 is an essential co-factor for MAO enzymes, meaning MAO relies on riboflavin to function optimally. This connection is especially relevant to serotonin metabolism.

Now, based on genetic predispositions - like those linked to the MAOA gene (e.g., rs6323 on SNPedia) - we might speculate how riboflavin supplementation could impact different MAO activity levels:

  • For Low-MAO activity: Riboflavin may enhance serotonin breakdown, potentially helping to restore balance and reduce overstimulation (my case!!)
  • For High-MAO activity: Extra riboflavin might further accelerate neurotransmitter breakdown, possibly exacerbating issues like low mood / irritability / fatigue. In such cases, avoiding excess Vitamin B2 could make sense.

This is just my perspective based on my observation of me and my direct relatives…

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I have seen quite a bit of evidence that optimizing choline intake is important for brain health. Obviously, choline is controversial, because of the TMAO connection, so it’s complicated. Nonetheless, choline is not a “nice to have”, but a “must have”. It’s an essential nutrient. The link with dementias and neurodegeneration is very strong. Meanwhile many people are choline deficient.

The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort

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B2 is in the list; I know there is a lot there, but that is there, I also have a blog on B2 and it’s impact on neurocognitive decline.

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Good point on the choline, I’ve been struggling whether to include this. I guess if you already have a defect makes sense, doubt it effects likelihood of disease, which is what I’m aiming for.

As I have an intense interest in ApoE4 (given both my parents have one, my sister has 2, and I have 1, my nephew has 2 … ) I’m waiting to get some time, but have the youtube channel DrApoE4 and will be putting up information and videos soon.

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I’d be curious to hear more about NTFactor Lipids. Are there biomarkers one could track to see if they need them or not (or to evaluate efficacy)?

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Hype? I don’t know, but a fair bit of published literature, and a fairly inexpensive product - here are the details Ross Pelton (who is author of a great basic book on Rapamycin) sent me on this:
NTFactor Lipids Letter

I’ve become involved with Natural Therapeutics and their product NTFactor Lipids. NTFactor Lipids improves the function of mitochondrial membranes, reduces mitochondrial DNA damage, and results in increased levels of mitochondrial ATP production. NTFactor’s ability to repair and renew mitochondrial cellular membranes makes it one of the most important life extension therapies available today.

A significant number of scientific studies and articles have been published scientific journals on NTFactor Lipids™. A complete bibliography is available at: https://ntfactor.com/research/

Overview. Damage to mitochondrial membranes and declining ATP production is one of the proposed causes of biological aging. NTFactor Lipids consists of phospholipids that are identical to the phospholipids in cellular membranes in the human body.

Studies in animals and humans have documented that NTFactor Lipids restores, and/or renews mitochondrial membranes, and reduces levels of mitochondrial DNA damage, which results in increased production of ATP. In patient populations ranging from chronic fatigue and fibromyalgia to cancer and chemically exposed Gulf War veterans, NTFactor significantly decreases symptoms and improves quality-of-life.

NTFactor provides a wide range of impressive benefits

to the following broad patient populations.

Aging: Damage to cellular and mitochondrial membranes occurs in all chronic and acute health problems and in normal aging. NTFactor replaces damages, oxidized membranes, which results in increased mitochondrial ATP production, reduction of symptoms from a wide variety of medical conditions, and improved quality of life. (1)

Improves mitochondrial function: In animal & human clinical trials, NTFactor lipids results in reduction of mitochondrial DNA damage and improved mitochondrial membrane function. In one study, after 8-weeks of use, NTFactor resulted in 26.8% increase in mitochondrial function, which restored mitochondrial function to levels similarly found in young adults. (2)

Fatigue (one of the most common medical complaints) is due to damage to mitochondrial membranes and a decline in mitochondrial ATP production. Clinical trials in chronic fatigue, aging, obesity, cancer, Lyme disease and Gulf War Illness reveal that therapy with NTFactor reduces fatigue from 26% to 43%.(3)

NTFactor is not promoted as a therapy for any medical condition. However, studies have shown that the use of NTFactor by patients with the following conditions results in a significant reduction of symptoms and improved quality of life.

Gulf War Veterans exposed to chemical and biological toxins gain impressive reductions in symptoms of pain, fatigue, inflammation, insomnia, difficult breathing, and problems with vision and balance.(4)

Cancer patients: Side effects of chemotherapy can be reduced from 57-70% of patients and 81% of cancer patients report significant reductions in nausea, vomiting, fatigue diarrhea, headaches, and malaise.(5)

Diabetes/Metabolic Syndrome: over 6 months, participants using NTFactor experienced an average 58.6% reduction in fasting insulin levels and an average 31.8% reduction in homocysteine levels.(6)

Fibromyalgia: Patients with fibromyalgia experienced 27.2% reduction in pain, 37.8% reduction in fatigue, and 54.7% reduction in GI symptoms, and 39.1% overall improvement in Quality-of-Life indicators.(7)

Cardiovascular disease: improves blood lipids, lowers elevated blood pressure, improves apoA1 levels, 31.8% lowering of homocysteine & 59.6% reduction in fasting insulin in 6 months

Obesity & weigh loss: In a 2-month open label clinical trial, 63% of participants lost an average of 6.22 pounds along with an average 2.51-inch reduction in waist and 1.5-inch reduction in hip circumference.(8)

NTFactor Lipids improves Mitochondrial Membrane Function. Rhodamine 123 is a fluorescent dye that is an industry-recognized method of monitoring the trans-membrane electrical/chemical potential across mitochondrial membranes. If mitochondrial membrane potential falls below -150 mV, fluorescence does not occur. This indicates that protons are not flowing across mitochondrial membranes, which means the mitochondria is not working and ATP is not being produced.

In aged subjects with severe chronic fatigue, Rhodamine 123 fluorescence revealed that 8-weeks of supplementation with NTFactor Lipids resulted in significant improvements in the function of mitochondrial membranes with patients gaining a 40% reduction in fatigue.(9) Multiple studies like this have been published, which demonstrate that taking NTFactor Lipids improves mitochondrial function and the production of ATP. (see Rhodamine 123 PowerPoint slide below)

Summary: Damage to mitochondrial membranes and a decline in the production of ATP is one of the fundamental aspect of biological aging.

NTFactor Lipids is a Game Changer. It’s ability to protect, repair, and renew mitochondrial membranes, and increase production of ATP makes it one of the most important products available to improve health and slow down the process of biological aging.

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I need to evaluate these papers, cited in the “research” page:

  1. Sfera A, Hazan S, Klein C, Zapata-Martin del Campo CM, Sasannia S, Anton JJ, Rahman L, Andronescu CV, Sfera DO, Kozakidis Z, Nicolson GL. Microbial translocation disorders: assigning an etiology to idiopathic illnesses. Applied Microbiology 2023; 3(1): 212-240

  2. Nicolson, GL. Membrane Lipid Replacement—a functional approach to repairing cellular membranes, reducing symptoms, and restoring function.
    3.Functional Food Science 2022; 2(8): 198-204*
    (Click to read)

  3. Enhancement of Nutrient Bioavailability and Reductions in Symptom Severities in Chemically Exposed Veterans Townsend Letter 2022

  4. Nicolson GL, Settineri, R, Breeding PC. Recent Research on Membrane Lipid Replacement with NTFactor Lipids®: Enhancement of Nutrient Bioavailability and Reductions in Symptom Severities in Chemically Exposed Veterans Townsend Letter 2022
    (Click to read)

  5. Ash, M.E.; Settineri, R; Nicolson GL. Fatigue, Immunity and Inflammation: Their Resolution Using Natural Medicine. Townsend E Letter; June 4, 2022
    https://www.townsendletter.com/article/352-fatigue-immunity-inflammation-natural-resolution/

  6. Nicolson GL, Breeding PC. Membrane Lipid Replacement with glycerolphospholipids slowly reduces self-reported symptom severities in chemically exposed Gulf War veterans. International Journal of Translational Medicine 2022; 2(2):
    (Click to read)

  7. Settineri R, Ji J, Shields ZP, Shirvani T, McLaren CE, Nicolson GL. The effects of Membrane Lipid Replacement with NTFactor® Lipids on increasing the bioavailability of three test nutrients. Bioactive Compounds in Health & Disease 2022, 5(5): 106-116.
    (Click to read)

  8. Nicolson, G.L.; Ferreira deMattos, G.; Ash, M.; Settineri, R.; Escribá, P.V. Fundamentals of Membrane Lipid Replacement: A Natural Medicine Approach to Repairing Cellular Membranes and Reducing Fatigue, Pain, and Other Symptoms While Restoring Function in Chronic Illnesses and Aging. Membranes 2021, 11, 944.
    (Click to read)
    (Special Issue on Advances in Membrane Lipid Replacement and Therapy)

  9. Medica, A, Aitken,R, Nicolson, GL, Sheridan, AR, Swegen,A, De Luliis,G, Gibb,Z.Ferreira de Mattos G, Ash, ME, Settineri R. , Escriba, P. Glycerophospholipids protect stallion spermatozoa from oxidative damage in vitro. Reproductive and Fertility (2021) 2 199-209.
    (Click to read)

  10. Nicolson GL, Breeding PC. Membrane Lipid Replacement with NTFactor Lipids® reduces pain, fatigue, gastrointestinal and other symptoms in patients with peripheral pain. Townsend Letter2020; 449: 17-20.
    https://www.townsendletter.com/article/449-membrane-lipid-replacement-ntfactor/

  11. Nicolson GL, Settineri R. No Evidence of allergenic reactions to soy lecithin phospholipids used in Membrane Lipid Replacement Studies. Bioactive Compounds in Health and Disease 2021; 4(1): 9 – 13
    (Click to read)

  12. Nicolson GL, Breeding PC. Settineri R, Ferreira de Mattos G. Aging and chronic illnesses: Membrane Lipid Replacement for restoring mitochondrial function and reducing fatigue, pain, and other symptoms in aged individuals. Bioactive Comp. Health Dis. 2020; 3(10): 194-203.
    (Click to read)

  13. Nicolson GL, Breeding P. Membrane Lipid Replacement: reduction of pain, fatigue, gastrointestinal and other symptoms in patients with peripheral pain: case reports. Journal of Healthcare & Prevention 2020; 3(2): 1-4.
    (Click to read)

  14. Nicolson, G.L. and Breeding, P. Membrane Lipid Replacement with NT Factor Lipids and reducing fatigue, gastrointestinal and other symptoms in patients with peripheral pain: case reports. Case Reports and Reviews, 2020
    (Click to read)

  15. Nicolson GL, Ferriera de Mattos G. COVID-19 Coronavirus: Is infection along with Mycoplasma or other bacteria linked to progression to a lethal outcome? International Journal of Clinical Medicine 2020; 11: 282-302.
    (Click to read)

  16. Nicolson GL. Pathogenic mycoplasma infections in chronic illnesses: general considerations inselecting conventional and integrative treatments. International Journal of Clinical Medicine2019; 10: 477-522.
    (Click to read)

  17. Gonzalez MJ, Seyfried T, Nicolson GL, Barclay BJ, Matta J, Vasquez A, Agostino DD, Olalde J, Duconge J, Hunninghake R, Berdiel MJ, Cintron A. Mitochondrial correction: a new therapeutic paradigm for cancer and degenerative diseases. Journal of Orthomolecular Medicine 2018; 33(4): 1-20.
    (Click to read)

  18. Nicolson, G.L., Settineri, R., Ferreira, G. and Breeding, P. Reduction of pain, fatigue, gastrointestinal and other symptoms and improvement in quality of life indicators in fibromyalgia patients with Membrane Lipid Replacement glycerolphospholipids and controlled-release caffeine. Intern. J. Clin. Med. 2018; 9: 560-579.
    (Click to read)

  19. Ferreira, G. Costa, C., Bassaizteguy, V., Santos, M., Cardozo, R, Montes, J, Settineri, R. and Nicolson, G.L. Membrane Lipid Replacement promoted by Incubation of mature human spermatozoa with glycerolphospholipid mixtures increases their motility and resistance to oxidative damage, PlosOne(2018)
    (Click to read)

  20. Nicolson, G.L., Ferreira, G., Settineri, R., Ellithorpe, R.R., Breeding, P. and Ash, M.E. Mitochondrial dysfunction and chronic disease: treatment with Membrane Lipid Replacement and other natural supplements. MITOCHONDRIAL BIOLOGY AND EXPERIMENTAL THERAPEUTICS, Edited by Dr. Paulo J. Oliveira, Chapter 22, Springer Press, NY, 2018.
    (Click to read)

  21. Hiroshi, A., Terauchi, M., Osaka, Y., Akiyoshi, M., Kato, and Miyasaka, N. Effect of soy lecithin on fatigue and menopausal symptoms in middle-aged woman: a randomized, double-blind, placebo-controlled study. Nutrition Journal (2018) 17:4. 00
    (Click to read)

  22. Nicolson, G.L., and Ash, ME. Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues. Biochim. Biophys. Acta 2017; 1859: 1704-1724.
    (Click to read)

  23. Nicolson, G.L., Rosenblatt, S., Ferrira de Mattos, G., Breeding, P.C., Ellithorpe, R.R. and Ash, ME. Clinical use of Membrane Lipid Replacement supplements in restoring membrane function and reducing fatigue in chronic diseases and cancer. Discoveries 4(1):e54 (2016) DOI: 10.15190/d.2016.1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941554 OR http://www.immed.org/treatmentconsiderations/06.11.2016.update/Clinical_Uses_MLRNicolsonDiscoveries2016. OR (Click to read)

  24. Nicolson, G.L. Membrane Lipid Replacement: clinical studies using a natural medicine approach to restoring membrane function and improving health. Intern. Clin. Med. 7:133-143(2016).
    (Click to read)

  25. Ellithorpe, R.R, Settineri R., Ellithorpe, T. and Nicolson, G.L. Blood homocysteine and fasting insulin levels are reduced and erythrocyte sedimentation rates are increased with a glycophospholipid-vitamin formulation: a retrospective study in older subjects. Funct. Food Health Dis. 5(4): 126-135 (2015).
    (Click to read)

  26. Nicolson, G.L., Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Integr. Med. 13(4): 35-43 (2014)
    (Click to read)

  27. Nicolson, G.L., Settineri, R. and Ellithorpe, R. Neurodegenerative and fatiguing Illnesses, infections and mitochondrial dysfunction: use of natural supplements to improve mitochondrial function. Funct. Foods Health Dis. 4(1): 23-65 (2014).
    (Click to read)

  28. Nicolson, G.L. and Ash, M.E. Lipid Replacement Therapy: a natural medicine approach to replacing damaged phospholipids in cellular membranes and organelles and restoring function. Biochim. Biophys. Acta 1838: 1657-1679 (2014).
    (Click to read)

  29. Nicolson, G.L. Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Alt. Ther. Health Med. 20(Suppl. 1): 18-25 (2014).
    (Click to read)

  30. Ash, M., Settineri R. and Nicolson, G.L. Fatigue, Immunity and Inflammation: their resolution using natural medicine. Townsend Lett. 352(10): 48-51 (2012).
    http://www.townsendletter.com/Nov2012/fatigue1112.html

  31. Nicolson, G.L. Mitochondrial dysfunction and disease: loss of mitochondrial function in chronic diseases and its reversal with Lipid Replacement Therapy. Public Health Alert (10): 1-4 (2012).
    (Click to read)

  32. Nicolson, G.L., Settineri, R. and Ellithorpe, R. Lipid Replacement Therapy with a Glycophospholipid Formulation, NADH and CoQ10 Significantly Reduces Fatigue and Improves Mood and Cognition in Intractable Fatiguing Illnesses and Chronic Lyme Disease. Townsend Lett. 347(6): 58-61 (2012). http://www.townsendletter.com/June2012/June2012.html

  33. Nicolson, G.L., Settineri, R. and Ellithorpe, R. R. Glycophospholipid formulation with NADH and CoQ10 significantly reduces intractable fatigue in Western blot-positive chronic Lyme disease patients: preliminary report. Funct. Food Health Dis. 2(3): 35-47 (2012).
    (Click to read)

  34. Nicolson, G.L., Settineri, R. and Ellithorpe, R. R. Lipid Replacement Therapy with a glycophospholipid formulation with NADH and CoQ10 significantly reduces fatigue in intractable chronic fatiguing illnesses and chronic Lyme disease. Intern. J. Clin. Med. 3(3): 163-170 (2012).
    (Click to read)

  35. Ellithorpe, R.R., Settineri, R., Jacques, B. and Nicolson, G.L. Lipid Replacement Therapy functional food with NT Factor for reducing weight, girth, body mass, appetite, cravings for foods and fatigue while improving blood lipid profiles. Funct. Food Health Dis. 2(1): 11-24 (2012).
    (Click to read)

  36. Ellithorpe, R.R., Settineri, R., Mitchell, C.A., Jacques, B., Ellithorpe, T. and Nicolson, G.L. Lipid replacement therapy drink containing a glycophospholipid formulation rapidly and significantly reduces fatigue while improving energy and mental clarity. Funct. Food Health Dis. 1(8): 245-254 (2011).
    (Click to read)

  37. Nicolson, G.L. Nutritional supplements for cancer-associated fatigue and cancer therapy—A molecular basis for restoring mitochondrial function. In Topics in Cancer Survivorship, vol. 2, ISBN 978-953-307-894-6, InTech, Rijeka, 147-164 (2011).
    (Click to read)

  38. Nicolson, G.L. and Settineri, R. Lipid Replacement Therapy: a functional food approach with new formulations for reducing cellular oxidative damage, cancer-associated fatigue and the adverse effects of cancer therapy. Funct. Food Health Dis. 1(4): 135-160 (2011).
    (Click to read)

  39. Nicolson, G.L. An answer to the most common medical complaint—Fatigue. Explore 19: 1-4 (2010).
    (Click to read)

  40. Nicolson, G.L., Ellithorpe, R.R., Ayson-Mitchell, C., Jacques, B., and Settineri, R. Lipid Replacement Therapy with a glycophospholipid-antioxidant-vitamin formulation significantly reduces fatigue within one week. J. Am. Nutraceutical Assoc. 13(1): 10-14 (2010).
    (Click to read)

  41. Nicolson, G.L. Lipid replacement therapy: a nutraceutical approach for reducing cancer associated fatigue and the adverse effects of cancer therapy while restoring mitochondrial function. Cancer Metastasis Rev. 29(3): 543-552 (2010).
    (Click to read)

  42. Nicolson, G.L. Finally an answer to the most common medical complaint—Fatigue. Public Health Alert (10): 1-5 (2011).
    (Click to read)

  43. Nicolson, G.L., Ellithorpe, R., and Settineri, R. Dietary supplement Healthy Curb for reducing weight, girth, body mass, appetite and fatigue while improving blood lipid values with NT Factor Lipid Replacement Therapy. J. Invest Myalgic Encephalomyelitis 3(1): 39-48 (2009).
    (Click to read)

  44. Nicolson, G.L. and Conklin, K.A. Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastatic disease by Molecular Replacement Therapy. Clin. Exp. Metastasis 25: 161-169 (2008).
    (Click to read)

  45. Conklin, K.A. and Nicolson, G.L. Molecular replacement in cancer therapy: reversing cancer metabolic and mitochondrial dysfunction, fatigue and the adverse effects of therapy. Curr. Cancer Therapy Rev. 4: 66-76 (2008).
    (Click to read)

  46. Nicolson, G.L. Lipid replacement and antioxidant supplements to prevent membrane oxidation and restore mitochondrial function in metabolic syndrome and fatiguing illnesses. Townsend Lett. 286: 112-120 (2007).
    http://www.townsendletter.com/May2007/lipidreplace0507_0709.html

  47. Nicolson, G.L. Metabolic syndrome and mitochondrial function: molecular replacement and antioxidant supplements to prevent membrane oxidation and restore mitochondrial function. J. Cell. Biochem. 100: 1352-1369 (2007).
    (Click to read)

  48. Nicolson, G.L. and Conklin, K.A. Molecular replacement for cancer metabolic and mitochondrial dysfunction, fatigue and the adverse effects of cancer therapy. Cancer Genomics Proteomics 3: 159-168 (2006).
    (Click to read)

  49. Nicolson, G.L. and Ellithorpe, R. Lipid replacement and antioxidant nutritional therapy for restoring mitochondrial function and reducing fatigue in chronic fatigue syndrome and other fatiguing illnesses. Chronic Fatigue Syndr. 13(1): 57-68 (2006).
    (Click to read)

  50. Nicolson, G.L. Lipid Replacement/Antioxidant Therapy as an adjunct supplement to reduce the adverse effects of cancer therapy and restore mitochondrial function. Pathol. Oncol. Res. 11: 139-144 (2005).
    (Click to read)

  51. Nicolson, G.L. Lipid replacement/antioxidant therapy for anti-aging, fatigue and restoration of mitochondrial function. AgroFood High Tech 16(3): 20-23 (2004)
    (Click to read)

  52. Nicolson, G.L. Lipid replacement as an adjunct therapy in chronic fatigue, anti-aging and restoration of mitochondrial function. J. Am. Nutraceut. Assoc. 6(3): 22-28 (2003).
    (Click to read)

  53. Agadjanyan, M., Vasilevko, V., Ghochikyan, A., Berns, P., Kesslak, P., Settineri, R.A. and Nicolson, G.L. Nutritional supplement (NT Factor) restores mitochondrial function and reduces moderately severe fatigue in aged subjects. J. Chronic Fatigue Syndr. 11(3): 23-36 (2003).
    (Click to read)

  54. Ellithorpe, R.R., Settineri, R. and Nicolson, G.L. Reduction of fatigue by use of a dietary supplement containing glycophospholipids. Am. Nutraceut. Assoc. 6(1): 23-28 (2003).
    (Click to read)

  55. Nicolson, G.L. Chronic fatigue, aging, mitochondrial function and nutritional supplements. Townsend Letter Doctors 240(7): 72-76 (2003).
    (Click to read)

  56. Seidman, MD. NT Factor® Spares the Age Related loss of Nerve Function, Energy and Genetic damage in animals. (2002). Otolaryngology- Head and Neck Surgery, 127, pp.138-143.
    (Click to read)

  57. Seidman, MD. (2001). Polyunsaturated Phosphatidylcholine in NT Factor Improves Mitochondrial Function, Auditory Sensitivity and May Slow Some Aspects of the Aging Processes. Anti-Aging Medical News, Winter 2001.
    (Click to read)

  58. Nicolson, G.L. Lipid Replacement as an Adjunct to Therapy for Chronic Fatigue, Anti-Aging and Restoration of Mitochondrial Function. J. Am. Nutraceutical Assoc. 4(1):11-19 (2001).
    (Click to read)

  59. Colodny, L. (2000). Integration of Traditional and Complementary Medicine During Chemotherapy, A Physician’s Viewpoint: Interview with Rudy A. Segna, MD, FACOG. Journal of the American Nutraceutical Association, 3(3), pp.51-53.
    (Click to read)

  60. Cancer Patients had an improved Quality of Life when Taking NT Factor® with a multi-vitamin complex. (2000). Journal of the American Nutraceutical Association, 3(2), pp.17-25.
    (Click to read)

  61. Block, J. and Evans, S. (2000). . A Review of recent Results Addressing the Potential Benefits of Antioxidants with cancer Drug Therapy. Journal of the American Nutraceutical Association, 4(1), pp.11-19.
    (Click to read)

  62. Block, J. and Evans, S. (2000). Newburg, D. (1999). The Beneficial Effects of Phosphoglycolipid Extract, NT Factor, on Normal and Cancerous Cells. Proprietary Report. Journal of the American Nutraceutical Association, 3(3), pp.6-16.
    (Click to read)

  63. Blaylock, R. (2000). A Review of Conventional Cancer Prevention and Treatment and the Benefits of Adding Nutraceutical Supplements and Antioxidants to Treatment. Journal of American Nutraceutical Association. 3(3), Fall 2000.
    (Click to read)

  64. Newburg, D. (1999). The Beneficial Effects of Phosphoglycolipid Extract, NT Factor, on Normal and Cancerous Cells. Proprietary Report.
    (Click to read)

1 Like

Good luck! Looks like a solid task. Overall, I’m pretty happy taking the powder daily as 120 doses is something like $40 and I think it is probably a good supplement, but these things are always complicated and unclear.

2 Likes

I guess I’m adding this to my list!

*adds to cart

The potential issue with that supplement is that it’s a complete supplement stack in itself. It contains the phospholipids in addition to everything else.
Here is the composition from their patent and that they used in their papers:

NT2 B-Vitamin Complex

%
Daily Dose Size 5 Tablets Daily
Amount Per Daily Dose Value**
Vitamin E (as d-alpha tocopheryl succinate, 50 IU 167%
mixed tocopherols)
Thiamin (Vitamin B-1) (as thiamine HCl) 3.75 mg 250%
Riboflavin (Vitamin B-2) 4.25 mg 250%
Niacin (Vitamin B-3) (as niacinamide, 100 mg 500%
niacin)
Vitamin B-6 (as pyridoxine HCl) 10 mg 500%
Folate (as folic acid) 800 mcg 200%
Vitamin B-12 (as methylcobalamin, 1,000 mcg 16,667%
cyanocobalamin)
Biotin 750 mcg 250%
Pantothenic acid (as d-calcium pantothenate) 25 mg 250%
Calcium (as dicalcium phosphate, carbonate, 400 mg 40%
pyruvate, borogluconate, ascorbate and
d-Calcium pantothenate)
Phosphorus (as dicalcium phosphate) 125 mg 13%
Magnesium (as magnesium oxide) 125 mg 31%
OptiMSM ™ Methylsulfonylmethane 364 mg
Alpha Keto Glutaric Acid 300 mg
L-Carnipure ® L-Carnitine L-tartrate 225 mg
L-Tyrosine 150 mg
NT 2 4,000 mg

And here is the list of their ingredients on their web site:

NTFactor® is made of the following ingredients:

Phosphoglycolipids – Includes polyunsaturated phosphatidylcholine, glycolipids and other polyunsaturated phosphatidyl nutrients.

Bifido and Lactobacillus Bacterium – Freeze-dried and microencapsulated in a state of suspended animation with the potential to form healthy microflora colonies.

Growth Media – Foods and bacteria growth factors to support microflora colonies including rice bran extract, arginine, beet root fiber, black strap molasses, glycine, para-amino benzoate, leek, pantethine (bifido growth factor), taurine, garlic, calcium borogluconate, potassium citrate, spirulina, bromelain, natural vitamin E, calcium ascorbate, alpha-lipoic acid, oligosaccharides, B-6, niacinamide, riboflavin, inositol, niacin, calcium pantothenate, thiamin, B-12, folic acid, chromium picolinate.

It’s funny to see all that labelled as “Growth Media” maybe it’s to confuse people or for legal reasons?

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