https://ergo-log.com/edible-mushrooms-halve-the-risk-of-early-stage-dementia.html
Conclusion
“Using community-based data in Singapore, we found that mushroom consumption was associated with reduced odds or mild cognitive impairment”, the researchers summarize their findings. “Based on current evidence, we propose that mushroom consumption could be a potential preventive measure for slow cognitive decline and neurodegeneration in aging.”
Great coincidence today Lustgarten interviewed a lady from Blue California which is a company that supplies supplement companies somehow, to talk about ergothioneine:
I take 7 grams of powdered golden oyster mushroom daily in my kefir. I think I’m taking way too much, but it’s never been tested and I’ve been doing it for a couple years at least and no problems so I think it’s ok.
Researchers at Kumamoto University have demonstrated that long-term consumption of Tamogi-take mushrooms (Pleurotus cornucopiae) prevents age-related cardiovascular decline in male mice. The primary bioactive driver is identified as Ergothioneine (EGT), a highly stable dietary antioxidant. While the study’s title claims an extension of “healthy life expectancy,” the data strictly reflects improvements in cardiovascular healthspan markers at 14 months of age, with no actual lifespan survival curve generated.
The study fed mice a mushroom-blended chow engineered to deliver an equivalent of 70 mg/kg/day of EGT for 12 months. At the macroscopic level, the mushroom-fed cohort displayed significantly preserved left ventricular systolic function, reduced cardiac hypertrophy, and vastly superior vascular endothelial relaxation compared to standard chow controls. They also exhibited lower heart-weight to tibia-length ratios, indicating a resistance to age-induced structural cardiac enlargement. Functionally, the treated mice exhibited significantly higher exercise tolerance on a treadmill exhaustion test.
Mechanistically, EGT operates by upregulating the Nrf2-HO-1 antioxidant pathway in both cardiac and aortic tissues. This upregulation effectively blunted the accumulation of reactive oxygen species (ROS) and lipid peroxidation. Consequently, the suppression of oxidative stress prevented the induction of the senescence-associated secretory phenotype (SASP), as evidenced by reduced local expression of senescence markers (p53, p21, p16) and inflammatory cytokines.
A major confounder emerged during the trial: mice fed the mushroom blend spontaneously restricted their caloric intake by 15.8 percent. To rule out calorie restriction (CR) as the primary driver, the researchers ran a secondary experiment matching the control group’s weight to the mushroom group. The cardiovascular benefits persisted in the mushroom cohort, suggesting the EGT payload, rather than mild CR, drove the biological effects.
Source:
It is already established that EGT is a highly bioavailable antioxidant with a dedicated transporter (OCTN-1). The novelty here is the in vivo demonstration that lifelong dietary EGT prevents physical cardiac remodeling and preserves youthful endothelial vasorelaxation in middle-aged mice.
| Rank | Product / Brand Name (Exact Title) | Vendor | Total Weight (Original Unit & Grams) | Total Price (USD) | Cost Per 25mg Ergothioneine | Number Capsules Needed (25mg) |
|---|---|---|---|---|---|---|
| 1 | Nutricost L-Ergothioneine Supplement 30mg Per Serving, 120 Capsules | Target | 120 Capsules (3.6g) | $16.95 | $0.12 (16.95 / 3600 * 25) | 0.83 (1 Cap Yields 30mg) |
| 2 | Ergothioneine Supplement (EGT) 30mg of Pure, Plant-Based L-Ergothioneine Per Capsule, 60 Count by Double Wood | eBay (TrustyGoods1) | 60 Capsules (1.8g) | $17.94 | $0.25 (17.94 / 1800 * 25) | 0.83 (1 Cap Yields 30mg) |
| 3 | California Gold Nutrition, Ergothioneine, 25 mg, 90 Veggie Capsules | iHerb | 90 Capsules (2.25g) | $29.95 | $0.33 (29.95 / 2250 * 25) | 1 |
| 4 | California Gold Nutrition, Ergothioneine, 5 mg, 90 Veggie Capsules | iHerb | 90 Capsules (0.45g) | $17.09 | $0.95 (17.09 / 450 * 25) | 5 |
| 5 | California Gold Nutrition, Ergothioneine Mushroom Complex, 90 Veggie Capsules | iHerb | 90 Capsules (0.45g) | $18.91 | $1.05 (18.91 / 450 * 25) | 5 |
| 6 | GeneIII® L-Ergothioneine 30mg | GeneIII | 30 Capsules (0.9g) | $38.99 | $1.08 (38.99 / 900 * 25) | 0.83 (1 Cap Yields 30mg) |
| 7 | ProHealth Longevity, Ergothioneine, 25 mg, 30 Capsules | iHerb | 30 Capsules (0.75g) | $39.95 | $1.33 (39.95 / 750 * 25) | 1 |
| 8 | Life Extension Essential Youth L-Ergothioneine, 5 mg, 30 Veggie Caps | Swanson Vitamins | 30 Capsules (0.15g) | $15.30 | $2.55 (15.30 / 150 * 25) | 5 |
| 9 | Nature’s Fusions - L-Ergothioneine Mushroom Complex - 60 Pullulan Capsules | GNC | 60 Capsules (0.3g) | $32.99 | $2.75 (32.99 / 300 * 25) | 5 |
| 10 | ERGO+ Ergothioneine Supplement | Real Mushrooms | 60 Capsules (0.3g) | $34.95 | $2.91 (34.95 / 300 * 25) | 5 |
Fyi, I have not been using it lately, but on @Joseph_Lavelle ’s fullscript site, you can get the real mushrooms brand for $26.24. (It’s product specific, but some of his prices can’t be beaten anywhere).
Does anyone know if any of the lower cost options are of comparable quality?
(I bought oyster mushrooms this week, but alas, they were moldy on day 2, so I’m off mushrooms at the moment)
Perplexity:
For a 60-capsule bottle of Real Mushrooms Ergo+ costing $26.24, with 10 mg of L-ergothioneine per capsule, you’re paying $1.09 per 25 mg
I’m glad to hear the prices are good. I do not set the prices. I do set the discount which I’ve set to the highest allowable. I amazed that some discounted prices are still higher than Amazon but not all.
I appreciate you maxing out the discount.
It was just this week I bought this… even with 20% off sales, no other store came close!
(I imagine smaller doses from other brands might offer great deals, but 900mg in one pill can not be beat!)
I used to buy fresh oyster mushrooms, and dry them using a dehydrator. Then I powdered them using a coffee grinder.
I shifted to buying dried mushrooms to powder them. I will finish the dried mushrooms, and just buy powdered. I get them from
I take the mushroom powder with broth.
