We found that mice fed a HF-SHM (high fact-shiitake) diet had ∼86% smaller aortic lesion area than mice in both HF-C (P < 0.01) and MIX-C (P < 0.01) groups and also expressed 31-48% lower vascular cell adhesion molecule-1 levels (P < 0.05) than all other groups. Similarly, HF-PBM- (high fat-portobello) fed mice displayed a 70% reduction in aortic lesion area in the tricuspid valve only (P < 0.05). Both mushroom-fed groups had lower weight gain and fat mass (P < 0.05) than the control groups.
Full article below.
https://www.sciencedirect.com/science/article/pii/S0022316622166897?via%3Dihub
Human equivalent dosage is huge.
According to Wu et al. (12), 10% wt:wt mushroom powder in mice will translate to ∼11 g fresh mushroom/kg body weight, which is ∼750 g mushroom/d (10 servings/d) for a person with an average weight of 65–70 kg.
Assuming the powder is one tenth of fresh mushrooms, that is still 75g (five tablespoons) of powder per day. If the effects scale down linearly, then two tablespoons of powder would produce 40% of the benefit. That is a big if.
The full study has a pic of the lesion area.
LF-C low fat control
HF-C high fat control
HF-PBM high fat portobello
HF-SHM high fat shiitake
MIX-C mixed control