Metformin and its impact on exercise (on high dose 1700mg, N=46)

A study in 2019 by Aging Cell: Metformin can reduce lean body mass gain by 9.03% and thigh muscle mass gain by 7.07% in a 2019 study (1700mg dose), could it be dose-dependent? Also saw somewhere that Metformin decreased insulin sensitivity by 20%, but it also decreased VO2 Max by 11% so it’s a mixed bag.