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Our results suggest a dose and time of administration that may enhance melatonin’s sleep promoting effects (2-4 mg, 3 hours before bedtime) and, if replicated by large clinical trials, could guide clinical practice in managing sleep disturbances in children experiencing neuropsychiatric conditions.
Melatonin modulated the post-exercise amino acid profile in skeletal muscle, enhancing the levels of key metabolites involved in recovery and metabolic regulation, with no effects observed in liver tissue. These findings suggest a muscle-specific role for melatonin in supporting metabolic recovery after exercising.
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Indian preprint fwiw but @John_Hemming you might be interested as you mentioned copper before: Repurposing Melatonin in dual-mode for Wilson disease therapy as a Copper Chelator and an antioxidant agent 2025
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My point about copper is that it is an essential mineral, but not in large quantities. I have been supplementing copper which has helped, but my copper levels continue to bump along the bottom of the normal range. That is because I drink from time to time. (as in now and whilst at the BSRA conference). Incidentally I don’t have an issue with the BSRA conference having alcohol as part of the conference, but interestingly it was hard to avoid potatoes and rice.
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