Maraviroc Fights Middle-Aged Memory Loss (And Muscle Aging)

been playing with this one since last night and have improved drastically and keep improving so I’m not so sure about its effectiveness. Just reached level 12 on sequencing memory (from 4 last night lol) so while fun playing them not so sure of its effectiveness of them as I’ve been improving ever since I started. The one I’m stack at lower level 25% percentile seems the visual one, and I’m consistently bad at it lol. The rest of them the more i practice the better I get, so there is that.

[Human Benchmark
(Human Benchmark)

2 Likes

Two mental declines I am experiencing at my age are short-term memory and the one that really clues me in about age-related mental decline: the inability to do math in my head.
I used to be quite adept at this, but now I have to use a calculator for many things I used to do in my head.

Oddly, two things that I have been doing for years that I thought would be indicators of age-related mental decline are sudoku puzzles and crossword puzzles. I have suffered no decline in these areas. In fact, when it comes to crossword puzzles, I feel I am at my peak, so they are not good indicators of mild cognitive decline.

2 Likes

I tried the XpressO by MoCA.

1 Like

Now that you’ve been on the drug for a couple of months, have you noticed anything?

2 Likes

For me .memories are stromg… easy to access thoughts, names, incidents.

Using 75 mg every other day.

3 Likes

Usually they come in 150 mg tablets. Do you split it?

1 Like

Yes split and take 75 mg every other day… says don’t split… on label…but I do.

3 Likes

I don’t think your waning fluidity at mental math is a true sign of cognitive decline. That’s a skill that can wither from disuse because your brain takes those resources to put them elsewhere. It’s likely just an adaptation. Short term memory is a different thing.

Yeah, but my short-term memory sucks. This is somewhat subjective, as my doctor specializes in geriatrics, and the clinic I go to gives regular tests for short-term memory. It isn’t much of a test, IMO, and I always pass.

It is odd to me what my short-term memory can and cannot do. If I consciously have to remember a few words or numbers for a short time, I can do that.

What is missing is the subconscious part, where you automatically remember where you placed the tool you were just using. In other words, my left hand used to know what my right hand was doing most of the time. At all ages, we ask, “Why did I come into this room?” but I experience this more frequently now.**

2 Likes

I’d say the math thing is probably even more concerning especially if you know for sure there’s a difference. I was very good at math, but my skills have improved by age (mind you I’m nowhere near 80 yet and things can change) including my ability to do math in my head. As for short term memory mine has been shot for as long as I can remember, so no change there, good nor bad.

2 Likes

I will be finishing my N=1 experiment with Maraviroc in seven days. After starting with very small doses for the first few days to test for any adverse reactions, I increased the dose to 75 mg daily, taken with breakfast. I continued this 75 mg daily protocol for 3.5 months.

I have nothing significant to report. Subjectively, I noticed no changes, and my recent extensive blood tests did not show any meaningful differences compared with results from a year ago.

It is possible that Maraviroc provides long-term benefits that are not easily measured in the short term, but I have no evidence of anything beneficial up to this point. Regardless, I will not continue taking it because I already have too many other irons in the fire.

6 Likes

Any updates on this effort of yours? Let us know when you can.

Any updates on this effort of yours? Let us know when you can.

No, there’s nothing to report. There were not noticeable subjective or blood report effects while using it and nothing to report after stopping. I do a variety of exercises with different intensities weekly and I saw no effect either positive or negative on those. But, there could certainly be some benefit to using it on a long-term basis that my little trial would never see. However, I’ll need more of a guarantee of that to actually use it on a regular basis.

1 Like