This is exactly how I am… if I’m in NYC, I go go go with no breaks from the second I wake up until I go to bed… when I’m here… nope… for me, I think it’s related to ADD… if I’m interested, nothing can stop me… and if I’m not, it’s hard to get motivated… (ss-31 has been helping me in this regard, but so far, I’m not seeing this report from other people, so I’m not suggesting it and only sharing).
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Modafinil at doses of 200 mg a day does not affect my resting heart rate in any detectable way. The thing that affects my resting heart rate the most is recent physical activity. The more active I am and the more exercise I do, the lower my resting heart rate is.
“Years of consistent moderate exercise accumulate real cardiovascular benefit. The heart adaptations built over decades don’t disappear quickly”. I am definitely benefitting from this, as I no longer exercise at the level that I did for many years.
Exercise and going to the gym are not my favorite interventions. But I do them anyway.
The way the GLP-1s affect RHR is through significant weight loss. “The effect tends to be dose-dependent—greater weight loss correlates with greater RHR reduction.”
I think that GLP-1s combined with exercise would likely produce a significant reduction in RHR. I really do think that modafinil would definitely improve a person’s motivation and ability to do more exercise.
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Yes but in my case I’ve lost just around 10 lb (I’m on the lowest dose) but have experienced higher RHR. GLP1s affect that metric by raising sympathetic tone too. That’s been the problem for me and the solution is to work out. Maybe need modafinil for the motivation piece to do that 
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Matt interviews Dr. Christin Glorioso, neuroscientist, physician, and founder of NeuroAge Therapeutics. They have an interesting test that includes imaging, blood, genetic, and online cognitive testing. It’s about $1300 for the package, so I’m not rushing out to try it, but I’ll look into the free online test.
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Have you landed on your protocol?
I get mine on Monday, and to err on the side of caution, I thought I’d take 1/4 pill twice a week and then check liver labs in maybe 3 weeks ish
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Dosing seems to be different depending on whether you’re looking for muscle impact or cognitive impact.
- **Muscle strength/mass: low-dose 32–75 mg/day equivalent, perhaps pulsed.
- **Cognitive enhancement: 150 - 300 mg
I don’t want to take this daily, so I’m considering 150 mg once per week or perhaps 75 twice per week, as a start, then perhaps titrate up. Anyhow, need to take my cognitive test first.
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I think neuroage has a free cognitive test. What are you thinking of using? https://www.neuroagetx.com
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Yes, I’ll try that and a few others you listed in the earlier table. But I need to recover from my night of lemborexant hell first.
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humanbenchmark.com is another free and quick measurement of cognitive capabilities. It tracks your scores and charts them against population averages.
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Sorry, I am extremely skeptical of any company offering “free to begin with” and selling their own further testing.
Some legit alternatives to consider:
1. SAGE (Self-Administered Gerocognitive Exam)
From: Ohio State Wexner Medical Center Website: wexnermedical.osu.edu/brain-spine-neuro/memory-disorders/sage
SAGE is a brief self-administered cognitive screening instrument specifically designed to identify mild cognitive impairment (MCI) from any cause and early dementia. Its questions are intentionally more difficult than similar tools like the MMSE, in order to catch very mild impairments. It has a sensitivity of 79% and a false positive rate of just 5%. There is no fee for individual clinical or noncommercial educational use. Ohio State University Wexner Medical Center
SAGE has compared favorably to clinician-administered tests such as the MMSE and MoCA, as well as standard neuropsychological testing. Harvard Health It takes about 15 minutes with just pen and paper, and you bring the completed form to your doctor to score and discuss.
2. XpressO by MoCA (Montreal Cognitive Assessment)
From: MoCA Cognition / Alzheimer’s Foundation of America Website: alzfdn.org/get-a-free-screening or portal-us.mocacognition.com/register
The MoCA is widely considered the gold standard in cognitive screening. The MoCA test has been validated as a highly sensitive tool for early detection of mild cognitive impairment in hundreds of peer-reviewed studies since 2000, with a sensitivity of 90% for detecting MCI, compared to only 18% for the MMSE. Mocacognition
XpressO by MoCA is a self-administered app version designed to be user-friendly and accessible. The test consists of 3 trials involving logical puzzles, memorization tasks, and grid-based activities, and takes about 5–7 minutes. After completion, it provides a score and either prompts the user to visit a clinician or congratulates them on their performance. Practical Neurology
Registration is required but is completely free, with no strings attached. Results can be tracked over time, and your information is not shared with any third party. XpressO by MoCA Available on web, iOS, and Android.
3. BoCA™ (Boston Cognitive Assessment)
From: Boston Cognitive / Alzheimer’s Research Website: boca.alz.life
BoCA™ is a scientifically validated, self-administered digital cognitive assessment that takes under 10 minutes and evaluates cognitive performance across eight domains using randomized, non-repeating tasks — minimizing practice effects and supporting reliable longitudinal tracking. It has shown strong correlation with the MoCA (r = 0.85) and strong test-retest reliability. It is free to use, with optional paid features for providers. Alz This is a strong option if you want to track changes over time.
4. Mini-Cog
From: Mini-Cog.com (widely endorsed by AAFP and Alzheimer’s Association) Website: mini-cog.com
The Mini-Cog is a three-minute instrument consisting of two components: a three-item recall test for memory and a clock drawing test. It is free and available in many languages. AAFP It’s simpler than the others and is normally administered by another person (a family member can do it), making it a good option if you want a quick, easy check that involves a caregiver or family member.
Important Notes for All Tests
- None of these are diagnostic. They are screening tools to help you decide whether to seek a professional evaluation.
And perhaps to establish a baseline to measure the cognitive benefit results from various supplements or drugs that we are trying.
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Thanks for these. I’ll check some of them out. Have you tried any? If so, what do you think?
Out of curiosity why are you guys so obsessed with cognitive tests. I can tell by the way you guys wright that you’re way better than average so I don’t get all the interest in these tests, and finally wouldn’t you know (easily) if something is royally screwed on your head anyway lol. I know for a fact that I have a bit of a memory loss (about 5%) as an example, but my other mental laurels are just same as always LOL. I’m genuinely asking though…
For me, it’s mostly about memory. I know from IQ tests that my intelligence is high, as I expect is true of most on this site. But my short-term memory has always been poor, and I want to baseline it to see if treatments I’m going to try (maraviroc, lithium) have an impact. I’m not sure these tests are sensitive enough to show the difference if there is one, but they are free and fast, so I may as well give it a shot.
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Took one of above tests and holly shit I knew my memory is bad but didn’t know was this bad lol sequence memory and visual memory I’m at only 5th percentile, unless I don’t know how to read it lol Does it mean only 5% of people are as bad as me, or only 5% are as good if you are in the 5th percentile? I’m confused…I just double checked it, I think it’s bad LOL. Dang I’m getting old
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Have you tried any? If so, what do you think?
No, not yet. I’m afraid to😅
Some morning when I’m feeling particularly lucid and perky I may try them. I have some maraviroc on the way. I plan on taking some of those tests before taking mavaviroc.
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Yes, I’ve gotten Maraviroc from Oddway last month. Tried multiple pharmacies but paid a little more for reputation. I have started low with roughly 37.5 mg twice see for 2🤔 weeks (by the way I’ve paused my rapa) then every other day for 2 weeks now 4 xs weekly. for 2 weeks. I’m about to go to 50 mg 3 4 xs weekly. Half life is 14-18 hours so some day I may go daily, we’ll see. I’m in pre licensing for my brokers license, 150 hrs of intense mostly irrelevant info but my 74 yo brain is humming along digesting it well. I’m a former team USA fencer , 2003,and I work out 3 xs weekly. Plus daily 45 min am home mid intensity work. I must say that today’s workout was longer , heavier, and easier than it’s been in 3-4 yrs as I was telling my partner at dinner today. Who knows, cud be placebo but wow, I’ll take it. More to come soon.
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It’s key to measure before and after if you want to see if something is benefiting you. Obviously the more you test, the better the baseline and ability to identify any variances.
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