Loss of Epigenetic Information Can Drive Aging, Restoration Can Reverse It

[Colin_McRae]

Loss of Epigenetic Information Can Drive Aging, Restoration Can Reverse It

[John_Hemming]

I think best to look at this thread:

Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice

A study published today (January 12) in Cell provides evidence that epigenetic disruptions alone accelerate the molecular, physiological, and neurocognitive aging in mice, and that this is driven by the cellular response to DNA damage, such as double-strand breaks (DSBs). By activating specific genes highly expressed during mammalian development, the researchers were able to restore the epigenetic landscape disrupted by the DNA repair process in their aging mouse model, leading to signs of rejuvenation From David Sinclair’s lab The Paper:

[Colin_McRae]

Yes. Definitely. Thank you!