Large Study Finds Viagra Is Linked to Almost 70% Lower Risk of Alzheimer's

I’ve been taking tadalafil 5mg od for a while. I have tinnitus; have had it for years; have detected no change to the tinnitus since using tadalafil. However I wonder there is any advantage it cutting down from 5 to a 2.5mg dose to lessen risk of ototoxicity?

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FWIW

Do finger pricks also suffer from Vit C bias? Perhaps you can use that to triangulate. Also, heard Freestyle Libre may be more sensitive to Vit C than Dexcom, but have no idea if that is true.

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Browsing through old post came across this and I do have tinnitus. no clue of the cause. I’m wondering is anyone in here in the same boat, and does anyone have any suggestion on mitigating tinnitus?

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Sorry, I have tinnitus an have found nothing that mitigates it.

I have had tinnitus since childhood, mainly in my left ear. I have been searching for a cure for decades. If there was a cure, I think I would have found it by now. You can ignore the supplement claims and BS YouTube videos.

The reason that I think that there is a cure to be had is, occasionally, at night, just before I go to sleep, it disappears completely, only to reappear the next day.

“Currently, there is no known cure for tinnitus.”

Tinnitus | Johns Hopkins Medicine.

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might be worth checking this out:

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This might also be interesting to look into. Also coming out of Stanford (but I think separately):

“Experience bimodal stimulation in daily 10-minute sessions for 8 weeks to feel relief.”

Professor David Eagleman is an American neuroscientist, author, and science communicator. He teaches neuroscience at Stanford University

Tinnitus affects 10 – 15% of the population. It’s not rare, but it can be difficult to live with. There’s no cure for tinnitus, but new neuroscience research shows that pairing notes with touch (known as bimodal stimulation) can reduce the volume and annoyance of ringing in the ears. This research was originally done with tones plus shocks on the tongue (Marks et al 2018; Conlon et al 2020), but that approach requires going into an audiology clinic every day for treatment.

Now bimodal stimulation has a new approach.

With Neosensory Duo, we have made bimodal stimulation simpler and more effective. First, no doctor’s visit is required. We mail the wristband to your home. You simply download our free app, put on the wristband, and listen to a specially designed series of notes for 10 minutes a day. The sounds and patented vibrations are synchronized. Over time, this teaches the brain which sounds are real (external) and which are self-generated (internal). Over the course of weeks, your brain learns to pay less attention to the internal sounds, and tinnitus becomes less challenging to deal with on a daily basis. Most customers participate in our subscription program for 2 months, some find it useful to keep it for 3 months, and others keep it forever.

Does seem expensive, but if only 2-3 months are needed then perhaps it could we worth it. Or perhaps you can get insurance to cover it. They do have a 30-day money back guarantee.

www.tinnitusjournal.com/articles/bimodal-stimulation-for-the-reduction-of-tinnitus-using-vibration-on-the-skin.pdf

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Interesting that’s exactly what happens with me at times. First time it disappeared it felt so good and really thought that’s was it, no more tinnitus. Unfortunately next morning woke up the same lol. Still searching sometimes I’m tempted to blow air with a bit of high pressure to see if helps. But then I’m like better tinnitus than def. But I’m optimistic that In my lifetime I’ll beat this bastard someday lol

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Thanks. Will do some reading as I’m in a mission to try and find something that works

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The researchers noticed a distinctive pattern. The men who were prescribed Viagra or a similar drug had an 18 percent lower risk of developing Alzheimer’s disease, compared with men who weren’t given the medication.

The researchers also found an even larger difference in men who appeared to use Viagra more often. Among the highest users, based on total prescriptions, the risk of being diagnosed with Alzheimer’s was 44 percent lower. (Men with erectile dysfunction are instructed to only take Viagra before sex, and no more than once a day.)

Full Article: Washington Post, Why Viagra has been linked with better brain health, Feb. 22, 2024

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A good “hack” for people who get a headache after taking sildenafil, is taking it sublingual. Bad tasting, but no headache

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Why would that be the case, I wonder? The headache is from vasodilation, so why would taking it sublingually give you vasodilation where you need it, but not in the brain?

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Recent Paper:

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Note that these studies are very specific to sildenafil/Viagra. It seems like a lot of people just assume that tadalafil/Cialis does the same thing because it’s also a PDE5 inhibitor, but when you look at the proposed mechanism, it appears to be a direct result of the structure of the sildenafil molecule inhibiting tau phosphorylation. I haven’t seen anything suggesting tadalafil does or doesn’t have a similar effect (but I also haven’t looked very hard).

It’s also interesting that the lower, three times daily dosing of sildenafil doesn’t appear to have a protective effect, so maybe there’s a dosing threshold required to get enough sildenafil into the brain?

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I’d like to know this as well. If these studies carry over to tadalafil. I take sildenafil multiple times a week, usually between 25-50mg. I personally think it’s the best drug on the market for quality of life for lots of reasons! :slight_smile:

It’s easy to get your doctor to prescribe it as long as you’re willing to have the conversation (I wouldn’t recommend it until you’re 40+). It’s also super cheap. You can get a 20ct of 100mg refill from https://costplusdrugs.com/ shipped to your door for $12. I cut the pills in half/thirds based on my doctor’s advice.

I don’t plan on switching to tadalafil anytime soon. But, I figured I might when I get to my mid 40s or early 50s. However, if we find out that all these benefits are strictly from something that sildenafil does, I likely won’t ever switch.

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It’s possible, I would say even likely, that other PDE5 inhibitors would have the same effect. The authors note that sildenafil has specific effects seen in silico (i.e. petri dish), and they speculate that these effects are what cause the lowered AD risk, but the lowered AD risk could be due to something completely different and they have no way of knowing. Remember that the beta amyloid theory seems to have been debunked (or at least isn’t the whole story).

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The in vitro (not in silico: that means computer modeling) effects were on tau phosphorylation, not anything to do with beta-amyloid, so the question about the role of beta-amyloid is not relevant.

I agree, though, that they haven’t conclusively shown that the risk reduction is due to this effect; indeed, they haven’t yet shown that it’s anything other than an association, and at least one other study was negative.

As a separate matter, the only disease-modifying therapies we have against AD are antibodies that remove it, and the amount and pace of amyloid clearance closely correlates with effect on disease progression, so it’s on as solid a footing as one can get (though of course not the whole story — no one ever said it was).

I just started Tadalafil 5mg about a week ago now and im taking it for the anti-cardiovascular disease effects, increased bloodflow to the brain, and its anti-inflammatory benefit. Doesn’t hurt, that it improves your erections either. I take my tablet once daily in the mornings with my other blood pressure medication since it does help lower blood pressure.

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Yet another significant confirmatory data analysis from the UK

The one looking at Rx’s of PDE5 Inhibitors and rate of AD. I’d say the evidence is looking pretty good that this is a real effect.

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My take home from that paper:

“a randomized controlled trial including both sexes and exploring various PDE5I doses would be beneficial to confirm the association between PDE5I and AD.”

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