I am not on X. The ITP page for Supported Interventions does not seem to be up to date.
Does anyone have a link to a web page being continuously updated?
I have no direct knowledge but ITP could have been among the billions of health research defunded by RFK-Jr and the Trump administration.
https://www.nature.com/immersive/d41586-026-00088-9/index.html
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If Rapamycin News leadership were to start a Go Fund Me to investigate the matter and get donations to fund the research, I’ll donate $1000 to continue the tests.
Every 6 months we could advertise the project and have a Go Fund Me drive to pay for the next series of tests.
I only noticed the issue due to the results on the ITP website not having been updated. A quick search of this forum produced some results back in 2024…again, the ITP page was not updated.
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I would donate as well if a portion of the research activities were allocated to human research, at the least mammals broadly biologically similar to humans. Mice are favored because they are cheap and their environment can be controlled more easily than that of many other mammals. They were not chosen because findings generalize well to humans.
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U will be amazed how similar we are to mice
Its generally
Worms
Mice
Primates
Humans
Primates arw v ezpensive for obvious reasons
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Useful information and economically secured, to be sure, but also hyper-interpreted. From my scan a year ago, the range of scientific judgment places the generalizability of mouse research to the same human condition or function within a range of from less than 10% to 20%. Several selection biases are operative when we look at such data. Journals have a bias against publishing negative findings (unscientific because negations of these types generally contain more information) and the failures to generalize that are published are soon forgotten.
Well, the purpose of the ITP is to perform a really well controlled, large sample animal experiment. Basically a multi-site clinical trial, but in mice. Otherwise we’re left with small studies from single labs, and we’ve already learned that they have pretty poor reproducibility.
The “good” news IMO is that ageing processes seem to be fairly well conserved between species. So while mouse studies in general are limited for things like cancer or neurodegeneration, if something really does slow down mouse ageing, I do think there’s a higher % it will also work in humans.
And unfortunately, if the ITP budget really is cut, then trying to self-fund something even more expensive seems like an impossible task. Hopefully a wealthy health enthusiast like Bryan Johnson could fund it. From what Rich Miller said, their entire budget was only a few million $ per year, which isn’t a crazy sum. Or other countries should pick up the slack. There should be a European ITP equivalent
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I’ve emailed Rich Miller and his team to get an update on the status of his group’s funding. Will report back when I hear from them.
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Thank you!
Bryan Johnson the last hope for humanity
He is creating a longevity fund with millions of dollars, I hope he puts some of this towards studies instead of just creating longevity health centres. The more studies the more cool new stuff we all learn about to use.
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Why are people so obsessed that Bryan Johnson should fund ITP-type studies? You could ask Jeff Bezos instead
Human longevity IMO is about lifestyle and drugs in or after phase 3 human trials.
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The response I got back today from Rich Miller:
The ITP received NIH funding for the five year period ending 5/31/2029. So we are eager to have applications for drug tests this year. The deadline is Feb 27, 2026.
In prior years annual announcements were made in the NIH Guide. This year, new policies at NIH (temporarily) prevented us from making an announcement in the NIH Guide, though one did appear, belatedly, on Feb 18, 2026, i.e. 9 days prior to the deadline (NOT-AG-25-014.) We did place notices in various NIA and related newsletters, but not in the NIH Guide. Perhaps next year we will be able to make a public announcement in a more timely fashion.
As to 'public fundraising" - it is my impression that NIH does not get involved in using non-governmental funds to support NIH-funded research. On the other hand, any group that raises funds to support research is free to use those funds to support research projects at any laboratory or university or center it deems appropriate, and ITP labs often are able to accept non-NIH funds for specific research purposes. Let me know if you’d like to discuss this idea further, either with me or with all of the ITP Site Directors.
I’ll look forward to seeing your applications.
Rich
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Well, I don’t think anybody is “obsessed”, but obviously he’s famously wealthy and has a global mission to help everybody live longer. So he’s a natural go-to for something like this.
On the other hand, I’m not sure Bezos gives a shit about anything except himself. But if he, or any other billionaire, would like to support basic scientific research, I’ll gladly commend them for it.
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The interesting part about capitalism you generally need to create value for others to make money, and Bezos have with Amazon. Let’s not forget Bezos Expeditions, Blue Origin, and Altos Labs. Even if that’s true – which it isn’t, there has been a lot of value created.
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If the elite see a benefit in it for them, they act on it. We have to “go there” to reach them.
I always give people the benefit of the doubt in stepping up and doing the right thing. They could do it on their death bed. It is never too late to help a fellow man or humanity.
I never knew anyone like Bezos, Musk, or Bryan Johnson and if I knew them in passing, how well would I really know them. You think that you know your partner until they walk out on you and try to take you for everything that you’ve got. You think that you know your immediate family, until one of them tries to cut you out of the family will and leave you destitute.
So my takeaway from this is that nothing has changed. Everyone can relax.
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the rich are very obsessed with good health and longevity man
let’s hope they actually fund some breakthrough soon.
most of us are powerless to do anything except read, eat, sleep, work as the serfs of 2026 (that’s what we will be known as in history 100 years later…the kids then will be laughing at us…my god…look at these guys using 100mbps internet forums…we are using quantum computing and everyone of us are AI owners who don’t even work
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Because Bryan Johnson is rich and interested in longevity. He has created a longevity fund to put towards things important for longevity. Why wouldn’t he start doing this? He could use his money and influence to get people with far more money than him to put their money towards this.
I can’t see why rich people aren’t clamoring for such a project. You can’t take the money with you after you die.
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Two problems with your comment:
First the rich are not known to favour distribution of wealth to the less fortunate. Just look at the accelerating wealth disparity between the rich and everyone else.
Second, given our current foolish ( insane ? ) failure to adequately address global heating there is considerable doubt whether anyone will be here in 100 years.
Hope I am wrong on both counts,
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