Is Covid Rewriting the Rules of Aging?

[KarlT]

Good to hear. I wish they would do studies to determine if T cell exhaustion could occur.

[Neo]

@AnUser

I’ve been thinking about nasal sprays to block infections as well.

This is a quite interesting area. At the same time, key that the nasal pray does not have any bacterial growth in it as you are spraying it so close to the brain I think?

[AJD]

I was a participant in the whole cycle of Novavax clinical trials and so have had every one of the vaccines and boosters. Their effectiveness has been (as documented) exemplary. Apart from the expected day of flu-like symptoms following them I have no complaints. Moreover, I may be the only person I know who has never had COVID despite being in the crowded gym at least 5 days a week (starting as soon as they reopened during the pandemic) and on airplanes regularly.

The endless delay in approving the Novavax vaccine is an appalling commentary on how corrupt the FDA approval process has been for the COVID vaccines. It has a better safety record and uses a more well-studied technology than all of the mRNA vaccines, and yet still does not have permanent approval. SMH.

[sudiki]

and i have never had (to my knowledge) covid either and I didn’t do anything special to avoid it other than wearing the mask back when it was “mandatory” when covid was at it’s peak…I am a gym rat too; 7 days a week

[Gokhan]

I took two doses of Novavax so far (if my memory serves me right) and multiple doses of mRNA.

• Novavax: Very smart bet. Almost a no brainer. I wasn’t able to find it last time in all of bay area!!! which brings us to…
• mRNA: I think the sides aren’t worth it. It’s almost as bad as getting sick if you ask me. I got the omicron variant last year, and expected it to be easier. It wasn’t! I think I’m done with it.

For further consideration: Flu vaccine (ref)

• [RCT] 11%-42% reduction in all cause mortality in RCTs and prospective cohort studies (ref, ref, ref).
• [Association] 43% reduction in all cause mortality, which was a very consistent finding across 40+ studies (ref, ref).
• [Association] All cause mortality was reduced in adults with diabetes (ref), hypertension (ref), cardiovascular disease (ref), cancer (ref).
• [Association] Lowered Alzheimer’s risk by 25-40% (ref, ref).

[Raquel]

The problem of relying on AI is that whenever you question some details or add results of some studies not included in the answer, the AI returns apologizing, praising your “intelligent consideration” and making the previous result different or reaching different conclusions. You cannot blindly follow the answers, you need to know the subject deeply to distinguish contexts, missing rational, and errors of interpretation. At least, that’s my experience to date.

[Jerry_Cahill]

The Novamax looks promising. I will wait a bit.

I recently saw something saying that the Shingles vaccine limited Dementia by 11% and the article suggested other vaccines had a positive effect in this area. I’ll have to see if I can find this info.

[Neo]

@Raquel

You cannot blindly follow the answers

Of course. How you prompt / formulate the questions is very important. You can see that I’ve given that feedback elsewhere on the forum when I’ve seen these models being use in a sub-optimal way.

When asking for studies or data things tend to be a bit better, but even then AIs are not yet great at weighing different sources and papers against each other.

The point here was whether there were any studies and data or not. And it seems like the answer to that is - yes, there is some.

[Neo]

@Jerry_Cahill

recently saw something saying that the Shingles vaccine limited Dementia by 11% and the article suggested other vaccines had a positive effect in this area. I’ll have to see if I can find this info.

You might find the studies linked to and discussed here relevant and helpful

Vaccines for longevity

It looks like vaccines should be useful for longevity because they prevent serious illnesses caused by viruses, but also because many other conditions often associated with age seem to be triggered by viral infections For instance, see: i) Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis ii) Possible Connection Between Herpes Group of Viruses and Various Conditions that Arise with Age iii) Lower Risk for Dementia Following Adult Tetanus, Diphtheria, and Pertussis (Tdap) Vaccination The question I had is what are the vaccines that are currently available for adults to take? Do you know where I can find this information? Here’s CDC’s recommended adult immunization schedule. Adult Immunization Schedule by Vaccine and Age Group | CDC But I’m sure this should be missing many other available vaccines just because some viral infections are currently deemed as low risk or low incidence

[Raquel]

Very well. Good also to remember that most of times studies give the “relative” risk, which is usually frustrating once you (if you) can translate to absolute risk. The dementia studies is just one example.

[dlkmd]

CronosTempi, thx for this post. As an MD focused on patients with Long Covid, I want to underline you comments hundred fold. My only additional comment is that the data is very clear and repeated in numerous studies: vaccine reduces the risk of LC, masking reduces the risk of Covid.
If someone prefers to drink the RFK/DJT kool aid, then nothing I can do to stop them.
But the rest of you should keep up with vaccines and mask when appropriate, eg airports, planes, crowded venues.
Belive me: you do not want to have Long Covid!!!