https://pmc.ncbi.nlm.nih.gov/articles/PMC10361652/
https://www.bmj.com/content/383/bmj-2023-076990?utm_source=chatgpt.com
https://www.nature.com/articles/s41590-024-01868-z?utm_source=chatgpt.com
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These might also be of interest:
Eric Topol’s Ground Truths articles discussing the relationship between COVID-19 and dementia risks:
1. The Brain and Long Covid
Discusses UK Biobank findings showing brain atrophy and cognitive decline in individuals post-COVID-19 infection.
2. Long Covid at 3 Years
Highlights studies indicating a correlation between prior SARS-CoV-2 infection and increased risk of Alzheimer’s disease.
3. Long Covid and Cognitive Deficits
Explores the potential for increased risk of Parkinson’s disease and dementia years after COVID-19 infection.
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Thanks, @Neo I’m pretty bullish on COVID vaccines (I’ve had 4 or 5 or so).
Does anyone have a good dashboard to track viral infections in local population. It would be helpful to know when we are in middle of an infectious wave. Bad outcomes aside it’s annoying to get sick.
With AI agents maybe it will be possible to create a dashboard easily later on.
I’ve been thinking about nasal sprays to block infections as well.
In the US these might help
And
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So does Covid vaccine help or hurt when in comes to dementia?
Long Covid and Cognitive Deficits
Explores the potential for increased risk of Parkinson’s disease and dementia years after COVID-19 infection
A potential association between COVID-19 vaccination and development of Alzheimer’s disease
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Myself and my wife get a booster every year or when there is a new updated vaccine. To date we have not experienced any side effects from the vaccines. We have been getting the Moderna although the very first one yrs ago was pfizer’s i believe. On that one we got the first shot then a few weeks later had to come back for the 2nd of the shot series.
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Good to hear. I wish they would do studies to determine if T cell exhaustion could occur.
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This is a quite interesting area. At the same time, key that the nasal pray does not have any bacterial growth in it as you are spraying it so close to the brain I think?
I was a participant in the whole cycle of Novavax clinical trials and so have had every one of the vaccines and boosters. Their effectiveness has been (as documented) exemplary. Apart from the expected day of flu-like symptoms following them I have no complaints. Moreover, I may be the only person I know who has never had COVID despite being in the crowded gym at least 5 days a week (starting as soon as they reopened during the pandemic) and on airplanes regularly.
The endless delay in approving the Novavax vaccine is an appalling commentary on how corrupt the FDA approval process has been for the COVID vaccines. It has a better safety record and uses a more well-studied technology than all of the mRNA vaccines, and yet still does not have permanent approval. SMH.
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and i have never had (to my knowledge) covid either and I didn’t do anything special to avoid it other than wearing the mask back when it was “mandatory” when covid was at it’s peak…I am a gym rat too; 7 days a week 
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I took two doses of Novavax so far (if my memory serves me right) and multiple doses of mRNA.
- Novavax: Very smart bet. Almost a no brainer. I wasn’t able to find it last time in all of bay area!!! which brings us to…
- mRNA: I think the sides aren’t worth it. It’s almost as bad as getting sick if you ask me. I got the omicron variant last year, and expected it to be easier. It wasn’t! I think I’m done with it.
For further consideration: Flu vaccine (ref)
- [RCT] 11%-42% reduction in all cause mortality in RCTs and prospective cohort studies (ref, ref, ref).
- [Association] 43% reduction in all cause mortality, which was a very consistent finding across 40+ studies (ref, ref).
- [Association] All cause mortality was reduced in adults with diabetes (ref), hypertension (ref), cardiovascular disease (ref), cancer (ref).
- [Association] Lowered Alzheimer’s risk by 25-40% (ref, ref).
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The problem of relying on AI is that whenever you question some details or add results of some studies not included in the answer, the AI returns apologizing, praising your “intelligent consideration” and making the previous result different or reaching different conclusions. You cannot blindly follow the answers, you need to know the subject deeply to distinguish contexts, missing rational, and errors of interpretation. At least, that’s my experience to date.
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The Novamax looks promising. I will wait a bit.
I recently saw something saying that the Shingles vaccine limited Dementia by 11% and the article suggested other vaccines had a positive effect in this area. I’ll have to see if I can find this info.
Of course. How you prompt / formulate the questions is very important. You can see that I’ve given that feedback elsewhere on the forum when I’ve seen these models being use in a sub-optimal way.
When asking for studies or data things tend to be a bit better, but even then AIs are not yet great at weighing different sources and papers against each other.
The point here was whether there were any studies and data or not. And it seems like the answer to that is - yes, there is some.
You might find the studies linked to and discussed here relevant and helpful
Very well. Good also to remember that most of times studies give the “relative” risk, which is usually frustrating once you (if you) can translate to absolute risk. The dementia studies is just one example.
CronosTempi, thx for this post. As an MD focused on patients with Long Covid, I want to underline you comments hundred fold. My only additional comment is that the data is very clear and repeated in numerous studies: vaccine reduces the risk of LC, masking reduces the risk of Covid.
If someone prefers to drink the RFK/DJT kool aid, then nothing I can do to stop them.
But the rest of you should keep up with vaccines and mask when appropriate, eg airports, planes, crowded venues.
Belive me: you do not want to have Long Covid!!!
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Prevalence of Persistent Cardiovascular and Pulmonary Abnormalities on PET/MRI and DECT Imaging in Long COVID Patients
“Ninety-eight patients (median age, 48.5 y; 47% men) were enrolled. The most common LC symptom was shortness of breath (80%), and 27% of participants were hospitalized. Of the subjects, 90% presented abnormalities in DECT, with 67% and 59% of participants demonstrating pulmonary infiltrates and abnormal perfusion, respectively. PET/MRI was abnormal for 57% of subjects: 24% showed cardiac involvement suggestive of myocarditis, 22% presented uptake reminiscent of pericarditis, 11% showed periannular uptake, and 30% showed vascular uptake (aortic or pulmonary). There was no myocardial, pericardial, periannular, or pulmonary uptake on the PET/MRI scans of the control group (n = 9). Analysis of plasma protein concentrations showed significant differences between the LC and the control groups. Lastly, the plasma protein profile was significantly different among LC patients with abnormal and normal PET/MRI. Conclusion: In LC subjects evaluated up to a year after coronavirus disease 2019 infection, our results indicate a high prevalence of abnormalities on PET/MRI and DECT, as well as significant differences in the peripheral biomarker profile, which might warrant further monitoring to exclude the development of complications such as pulmonary hypertension and valvular disease.“
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New Onset of Type 1 and Type 2 Diabetes Post-COVID-19 Infection: A Systematic Review
https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2492211
“COVID-19 may primarily cause respiratory symptoms but can lead to long-term effects known as long COVID. COVID-19-induced diabetes mellitus was reported in many patients which shares characteristics of types 1 and 2 (T1DM and T2DM). This study aims to identify and analyze the reported cases of new onset diabetes post-COVID-19 infection.”
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Excess weight is associated with neurological and neuropsychiatric symptoms in post-COVID-19 condition: A systematic review and meta-analysis
“Excess weight has been identified as a potential risk factor for post-COVID-19 condition (PCC). This systematic review and meta-analysis aimed to investigate whether excess weight is associated with the development or experience of neurological and neuropsychiatric symptoms in PCC.”
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