Is Covid Rewriting the Rules of Aging?

and i have never had (to my knowledge) covid either and I didn’t do anything special to avoid it other than wearing the mask back when it was “mandatory” when covid was at it’s peak…I am a gym rat too; 7 days a week :slight_smile:

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I took two doses of Novavax so far (if my memory serves me right) and multiple doses of mRNA.

  • Novavax: Very smart bet. Almost a no brainer. I wasn’t able to find it last time in all of bay area!!! which brings us to…
  • mRNA: I think the sides aren’t worth it. It’s almost as bad as getting sick if you ask me. I got the omicron variant last year, and expected it to be easier. It wasn’t! I think I’m done with it.

For further consideration: Flu vaccine (ref)

  • [RCT] 11%-42% reduction in all cause mortality in RCTs and prospective cohort studies (ref, ref, ref).
  • [Association] 43% reduction in all cause mortality, which was a very consistent finding across 40+ studies (ref, ref).
  • [Association] All cause mortality was reduced in adults with diabetes (ref), hypertension (ref), cardiovascular disease (ref), cancer (ref).
  • [Association] Lowered Alzheimer’s risk by 25-40% (ref, ref).

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The problem of relying on AI is that whenever you question some details or add results of some studies not included in the answer, the AI returns apologizing, praising your “intelligent consideration” and making the previous result different or reaching different conclusions. You cannot blindly follow the answers, you need to know the subject deeply to distinguish contexts, missing rational, and errors of interpretation. At least, that’s my experience to date.

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The Novamax looks promising. I will wait a bit.

I recently saw something saying that the Shingles vaccine limited Dementia by 11% and the article suggested other vaccines had a positive effect in this area. I’ll have to see if I can find this info.

Of course. How you prompt / formulate the questions is very important. You can see that I’ve given that feedback elsewhere on the forum when I’ve seen these models being use in a sub-optimal way.

When asking for studies or data things tend to be a bit better, but even then AIs are not yet great at weighing different sources and papers against each other.

The point here was whether there were any studies and data or not. And it seems like the answer to that is - yes, there is some.

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You might find the studies linked to and discussed here relevant and helpful

Very well. Good also to remember that most of times studies give the “relative” risk, which is usually frustrating once you (if you) can translate to absolute risk. The dementia studies is just one example.

CronosTempi, thx for this post. As an MD focused on patients with Long Covid, I want to underline you comments hundred fold. My only additional comment is that the data is very clear and repeated in numerous studies: vaccine reduces the risk of LC, masking reduces the risk of Covid.
If someone prefers to drink the RFK/DJT kool aid, then nothing I can do to stop them.
But the rest of you should keep up with vaccines and mask when appropriate, eg airports, planes, crowded venues.
Belive me: you do not want to have Long Covid!!!

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Prevalence of Persistent Cardiovascular and Pulmonary Abnormalities on PET/MRI and DECT Imaging in Long COVID Patients

“Ninety-eight patients (median age, 48.5 y; 47% men) were enrolled. The most common LC symptom was shortness of breath (80%), and 27% of participants were hospitalized. Of the subjects, 90% presented abnormalities in DECT, with 67% and 59% of participants demonstrating pulmonary infiltrates and abnormal perfusion, respectively. PET/MRI was abnormal for 57% of subjects: 24% showed cardiac involvement suggestive of myocarditis, 22% presented uptake reminiscent of pericarditis, 11% showed periannular uptake, and 30% showed vascular uptake (aortic or pulmonary). There was no myocardial, pericardial, periannular, or pulmonary uptake on the PET/MRI scans of the control group (n = 9). Analysis of plasma protein concentrations showed significant differences between the LC and the control groups. Lastly, the plasma protein profile was significantly different among LC patients with abnormal and normal PET/MRI. Conclusion: In LC subjects evaluated up to a year after coronavirus disease 2019 infection, our results indicate a high prevalence of abnormalities on PET/MRI and DECT, as well as significant differences in the peripheral biomarker profile, which might warrant further monitoring to exclude the development of complications such as pulmonary hypertension and valvular disease.“

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New Onset of Type 1 and Type 2 Diabetes Post-COVID-19 Infection: A Systematic Review

https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2492211

“COVID-19 may primarily cause respiratory symptoms but can lead to long-term effects known as long COVID. COVID-19-induced diabetes mellitus was reported in many patients which shares characteristics of types 1 and 2 (T1DM and T2DM). This study aims to identify and analyze the reported cases of new onset diabetes post-COVID-19 infection.”

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Excess weight is associated with neurological and neuropsychiatric symptoms in post-COVID-19 condition: A systematic review and meta-analysis

“Excess weight has been identified as a potential risk factor for post-COVID-19 condition (PCC). This systematic review and meta-analysis aimed to investigate whether excess weight is associated with the development or experience of neurological and neuropsychiatric symptoms in PCC.”

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For those of you continuing to get covid boosters, may I ask if you now getting them annually or semi annually?

I had been getting a vax every 6 months, but because cases have been much lower here, I’m currently aprox 9 months out. It seems that is about to change where I am.

If you are getting boosters, are you still choosing Moderna or Pfizer, or are you now considering Novavax? (So far, I’ve had all Moderna, except for one Pfizer).

Thank you in advance.

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I’m getting a covid booster annually with my flu shot. I prefer Moderna but usually take whatever they are using at the local pharmacy.

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Thx @59vw!

Also, an fyi to anyone interested…
I posed this question to two friends.

One is in involved in health policy (and who is about to quit because they can’t handle the stress!). I would take this persons advice with a grain of salt, but they didn’t mention which kind of vax, but said every 6 months is still reasonable.

However, my other friend is close friends with a well known immunologist and vaccine expert that I fully trust. They got back to me and said the advice was to still get it every 6 months and to get the same vaccine you had last time (unless of course a new more targeted one becomes available). There was no mention for or against novavax in the reply. I didn’t talk to the doctor myself.

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I should say I keep an eye on the testing and if elevated in my area I might do a 6 month booster. During summer the infection rate appears to be low around here so I’ll wait until Nov to get my covid/flu booster. I use this site to track covid cases in my locale.

With current RFKJ trends this site may go away soon but for now that’s my method. I want to avoid covid infections if I can!

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What do COVID vaccine skeptics or RFK fans think about this? Aren’t you unsatisfied with him not taking the gene therapy mRNA covid shots off the market that has killed millions of people, but actually approving a new one? Are you changing your mind that maybe it didn’t kill millions of people, and that it actually isn’t gene therapy, instead a very fragile strand of mRNA that produces viral inactivated proteins in mostly muscle cells in the shoulder? And actually a really great invention with wide use cases today and in the future?

Either way I’m interested to hear what RFK fans reactions are to this.

The U.S. approved a new COVID-19 vaccine made by Moderna late Friday but with limits on who can use it — not a replacement for the company’s existing shot, but a second option.

The new vaccine, mNexspike, is a step toward next-generation coronavirus vaccines. It’s made in a way that allows for a lower dose - a fifth of the dose of its current COVID-19 vaccine, Spikevax - by refining its immune target.

The approval “adds an important new tool to help protect people at high risk of severe disease from COVID-19,” Stephane Bancel, Moderna’s CEO, said in a statement Saturday.

The Food and Drug Administration approved the new vaccine for use in adults 65 and older and people age 12 to 64 who have at least one health condition that puts them at increased risk from the coronavirus.

(For those who are wondering, the randomized trial with placebo underway is for approving healthy 50-64 yrs)

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We’re working with limited information on this kind of like with Rapamycin. Nobody knows. You would think they would keep close track or conduct large experiments since we have great numbers on both sides. But no.

If the over 65’s die they save money and reduce inflation. Same with younger people on disability. Death is deflationary. So if you want to be paranoid there is fuel for that.

If you’re asking whether I think we got what we voted for? I’m old enough and have voted enough to know that never happens. At least they’re not threatening people that don’t want the shot.

It doesn’t bother me if people want to experiment with their health. More power to you. It would be good if we had more information. I have no ill will toward those with a different view.

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You should already know that FDA doesn’t approve any drug without experiments, both in animals and humans, I’ve skimmed such documents myself they’re hundreds of pages long with dozens of experiments. The COVID shots had participants up to 40,000 people for just one brand of shots. I think we already know what they do and can infer from basic biology 101 about mRNA functionality in cells (I can’t understate this enough, I learned about this when I was 20 yrs old 10 pages in a college biology textbook, and if you knew about that one page about mRNA it’s like a puzzle that fits in your mind and you’ll instantly recognize why this invention is so clever).

So you can question the experiments that have been done, including for the new COVID mRNA shots, but you can’t question that they haven’t been done, unless you appeal to conspiracy that they’re actually not real and hundreds if not tens of thousands of scientists are all in a grand conspiracy, which is not likely at all. Appreciate logical consistency here.

I do accept people don’t believe that such ten thousand participant trials haven’t been done or faked, just like some don’t believe all the video evidence of spherical earth. I don’t claim COVID vax skeptics are flat earthers if they believe this, just it’s the same “who knows what happens behind what I personally see?”, and if you were on the ground in the trenches actually reviewing the data, you couldn’t observe all 40,000 people taking the shots and what happened to them. It’s a never ending ladder of skepticism with no solid ground and goalposts that keep shifting.

As for RFK not fulfilling his perceived promises, maybe he realizes he was wrong, how do you know?

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I can’t speak for everyone, however, I think that many people who voiced objections were specifically against the vaccine mandates. Although one could technically decline a vaccine, it could preclude you from keeping your job, attending university, etc. That degree of coercion to put a foreign substance into one’s body is highly objectionable to many people.

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Yet it has been a requirement for decades (for example meningococcal vaccines necessary for enrollment at about 3/4 of US colleges and high schools).