Wow. Very interesting. Any other changes?
Were you also taking rapamycin at that time?
I had increased my aerobic exercise during that period. No major dietary changes (other than just eating less), no rapamycin or any other medications that Iām aware would have an effect.
Just curiousā¦ How much weight did you lose during this time? How many pounds or kilos? I wonder if thst might be driving the blood work changes and resulting bioage reduction.
Semiglutide is the only way I was able to rid my 20 lbs of post menopausal weight.
I initially started with a PA.
My dose was prescribed as follows:
One .4 mg (point 4, not 4) injection, one day a week (same day each week) for the first month.
Next, I increased dose .1 mg/10 units weekly for another month until I got to .08 mg/80 units.
This was the PAs decision and I think she was being cautious as it was a new medication for their office.
Iām pretty sure I was the Guinea Pig:)
(I use a 1 mg /100 unit syringe)
I followed instructions and stopped at .8 mg until I read more articles about its use, benefits, and dosing for weight loss specifically.
Please indulge me for a minute at this point. I want to mention things I wish Iād known prior, just to keep in mind.
When Googled, many reputable organizations, health orgs, specialists, and research articles were consistent in the safety of the higher doses mentioned previously. There arenāt any health issues that would prohibit me from going to more beneficial/reasonable and improved increases. My theory, again, is the Guinea Pig Theory.
On a brighter note, Iām very cautious AND confident about what I take/put in my body, how much, and from āwhereā.
You guessed it, YES, my doctors love me and all the research, new treatments, drugs in pipelineā¦about to arrive.
The first place I purchased from had everything put together in the ā2/3rds fullā vial (BWater and powder peptide)ā¦ I mention this so you arenāt shocked when you see what you just spent a lot of money on.
It really did help me with weight I was unable to budge as an older womenā¦
Item stays in fridge directly upon receipt.
Iāve noticed in researching that ordering powder is much cheaper- but still pretty expensive, Either ways works.
When you start, thereās seems to be some solution/powder missing. Knowing this before it arrives may help you a little w/the sticker shock. Just a note of caution, look at/in vial as soon as you get it. Iāve received an empty one before.
My final frontier is to do math, ugh, because I purchased āpowder onlyā and need to reconstitute.
No problem. Not the hard part.
Figuring out dose when one bottle reads 1 mg on front label (one with liquid already in it). The powder vial says 3 mg and leaves very little room for the liquid to dissolve.
My biggest takeaway (confusion really) was that my PAās āupward titratingā initial dose and cut off point, both seem pretty low after all Iāve read. .
One last thing. Promise.
I was pretty nauseous for awhile. Then it was gone as quickly as it came on.
Whew! Feels like I just write a book. Let me know if you have any questions about my experience with this product. I hope I answered your question in there somewhere!
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I recently started Ozempic as well. I went to a weight management type of NP with the intention of getting compounded semaglutide. I found her on Sesame. She suggested that I first attempt to get Ozempic covered by insurance and it worked out well. Iām very surprised my HMO insurance didnāt decline as Iām not diabetic. A1C is 5.7 and BMI is 29. However, my CVD markers are extremely bad, but thatās not an indication for the drug. I can only guess that the reviewing physician did consider overall risk.
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I had to provide my last annual notes, and all recent bloodwork. But I buy other, excuse me, I used to buy other peptide/nutrient injectableās from them and didnāt have to talk to their provider. I donāt know how many they have but I had a brief phone call, sent back any forms, and was prescribed it. Just over $100 for consult with specials monthly. The SG was $275 vial and $40 to overnight w/ice packs since they reconstituted it.
I have a friend who takes the other new injection for weight loss and itās covered by her insurance. Ins plans are vastly different so some will and some just wonāt. I wish anyone struggling with weight loss and wanted to use it could but itās expensive unless you have great insurance plan.
She gets the Mounjaro. Itās been in the news lately more 
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Thatās for a 3mg vial correct? Are you planning to go higher than 0.8mg/week and what do they charge for the stronger doses?
Iām pretty sure itās 3 mg (weight) of powder as thereās just a little in the vial. I used the peptide calculator, I can add link so you can see it. The first company sent a much larger vial premixed and it said 1 mg on vial. Anyway, Iāve not figured it out yet. Gotta call my peptide guy.
He did help me understand how to calculate, reconstitute ā¦ and we walked through one. But the vial, mg, dosing of mfg are so different, I want someone in the know to help me figure out 1 gram dose so I can double itā¦ with simple addition.
Yes, Iām already above the .8 mg dose.
In any research Iāve found, the dosage begins at
.4 or .5 (.5 is a half full 1 mg/ml syringe- for visual)
and titrates up to a recommended dose. I believe if you take too much, thinking itās helping to lose pounds, you may have to deal with low blood sugar.
So now I have this powder w/3 mg on the label (again weight of powder I believe), Iām trying to figure out a proper dose that I can manipulate easy. For example, when I figure out what 1 mg (not. 0.1) looks like by adding the recon water, Iāll likely start at 1 mg after taking .8 for long enough.
I used medical sites or pharma site for dosing.
Their recommended range is the manufacturerās
.5 mg - 4 mg. Quite a difference.
I believe, although itās not really settled into my synapses yet, if I want the dose to be a 1 mg full needle, itās about how much you reconstitute it with or diluting by adding more BS water.
He and I walked through another peptide recommended to me. We used the chart and the numbers were easy, all 19s.
10 mg, vial, water, doseā¦I donāt remember it exactly. But we did work out my recommended dose as 1 mg or one full syringe. (1 mg, 29x1/2ā).
Then I asked him if I put in only half of the biostatic water we worked out w/calculator, would the solution be ā2x as strongā so Iād only need 1/2 full (.5) solution in syringe and get the same dose. Yes, that was correct. So you can make a solution stronger by adding less BS water and take in same dose but have less in needle.
Does this make sense? Iāll go get the calculator. BRB.
PS Iām not proofing anymore. It takes too long. Bear with me on typos and autocorrect!
Calculator to play around with. Let me know if you get it right. And use good resources for range of dosing 
.
Interestingā¦ For that price you may be able to get a compound pharmacy to give you a higher grade product where you donāt have to fool around with volumetric calculations. IIRC it was around $250 for the beginner doses when I called around to local compounding pharmacies. Thereās a peptide supplier I found off reddit that was a bit cheaper. There are some risks injecting unclean products, as you may know. How did you vet your supplier? We really donāt know who is bootlegging these patented peptides. Novo Nordisk posted that they donāt supply it for anyone else to distribute.
Iāve been listening to body hack podcasters, researching anything I can find.
I am not looking to do aesthetic things. Iām working to feel my best. It seems anything āanti agingā seems to help with certain things I deal with too. They overlap.
Neuro protective, decreased inflammation, decreased oxidative stress tips, medsā¦ overlap anti-aging and certain chronic symptoms.
I do make sure the companies have all credentials I can gather ie: 3rd party testingā¦ I also have a good friend in Pakistan who knows the big, legit āpharmaciesā and she a researcher. She suggests some places if I canāt find here.
I really liked working directly with the PA when I first started my journey but they truly let me down when $315 worth of meds arrived in an empty vial and they didnāt even try to make it right. My fault, I guess or Iām lying - are the loud/clear messages I received.
Luckily, my primary care just asks me, what tests to you want to run. So I do.
Is there a primary pre-post test I should look at specifically to determine if a dose starts to go in the wrong direction vs beneficial?
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Given that Wegovy / Semaglutide GLP1 type drugs are in very high demand, and high priced (patent-predicted) I would expect a lot of the counterfeit / scam businesses are now focusing on this area as they can make a lot of money.
Given this, I think that the best approach now with this drug is to go only through legitimate US / Western (Canada/European) sources and channels.
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Ozempic shortage ongoing as prescriptions soar among global supply constraints.
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Rapamycin may be such a miracle drugā¦ This argues that (at least in rats) it resets the metabolism to a lower weight point - even with a single dose.
Single Rapamycin Administration Induces Prolonged Downward Shift in Defended Body Weight in Rats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008417/#__ffn_sectitle
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I recently had a good experience buying from Kachhela Medex: Rybelsus 14 mg tablets 30 tablets $ 120 USD, much lower than the price quoted above. I am going to start at 3.5mg tomorrow.
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Make sure you donāt cut or break the tablets. The coating helps with absorption
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from [Oral semaglutide, first oral GLP-1 receptor agonist (RybelsusĀ®)]. | Semantic Scholar
with an absorption enhancer, sodium N- (8- [2- hydroxybenzoyl] amino) caprylate (SNAC), which facilitates the absorption of semaglutide across the gastric epithelium in a concentration dependent manner
Is the absorption-enhacing SNAC in the coating? And if the semaglutide is absorbed āacross the gastric epithelium,ā then does it matter if the tablet is broken?
An interesting but non-definitive discussion on splitting the semaglutide pills:
This video describes the absorption process but does not talk about the coating:
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You make fair points
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people are desperate to have better health
Weāre all dead in the end anyway, so thereās risk in doing nothing too
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