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Thanks, that was great and really answered a lot of questions!
@RapAdmin that 2nd YouTube was good and answered my questions about ERK/AMPK/mTORC1 and Metformin, Rapamycin, Senolytics and Trametinib but @Krister_Kauppi YouTube was MUCH better and as a bonus you got Brian Kennedy!
Note: I need to look up STAT3
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From a pure efficacy standpoint you may be right… but you’re going to want to have a small molecule drug (ideally) or injection first because there are, to the best of my knowledge, no real templates of success for economically successful gene therapy companies targeting any sorts of diseases (that is, there have never been any successfully IPO’d disease-targeted gene therapy companies yet… so its a hard sell to investors.
Secondly, there are likely times when perhaps you want IL-11 turned back on (e.g. wound healing), or may want to stop the inhibition due to some unforeseen side effects, which obviously is much more difficult if gene therapy.
Lastly, getting transfection of gene therapies into all areas of the body, and all organs and tissue types (or even just the most important tissue types… which for IL-11 still isn’t identified, in terms of the longevity effect, is really hard. So - in the short to medium term (i.e. the next few decades) I anticipate all therapies are likely to be small molecule or injectables.
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Yes, Stuart talked about this briefly in the Healthy Longevity presentation. That it might be fine (like rapamycin) for it to be pulsed with periods of activity and inactivity.
It’s far too premature to strart looking into gene therapies for IL-11. If you could and would get a gene therapy to inhibit whatever new thing has recently been found to influence lifespan in rodents, you would do yourself a lot of harm. There are far too many unknown effects of globally inhibiting IL-11 constantly in the body in healthy people. These chemicals exist for a reason. There are going to be some negative effects from inhibiting IL-11, otherwise the body wouldn’t produce it. Before getting something like gene therapy, you better be very sure about the effects.
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Not necessarily. Sometimes the body does things that appear beneficial only during extreme circumstances, such as increasing apoB production during periods of no food availability.
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I agree with you.
Hot take: the constant fear mongering over Rapamycin side effects in people who take it intermittently is far more dangerous than actually taking Rapamycin intermittently.
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Yes, and… human-form IL-11 antibodies are readily available from many sources.
Is any self experimenter out there injecting himself with an IL-11 antibody?
Example Sources:
https://www.biocompare.com/pfu/110447/soids/315927/Antibodies/IL11
@MAC , this is probably a lot easier and safer than DIY rapamycin injections…
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I think I’d try it on my dog first…oh, wait, I don’t have a dog…he died in the last experiment 
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Intriguing that mTOR upregulation happens in tandem with the increase in IL-11 in people as they age. Almost a perfect correlation.
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As someone riddled with Auto Immune diseases, I may try this out, relatively soon. I experienced an improvement from Rapam… maybe this would help as well. Let me know if you have any ideas of proper ‘channels’ to get this from.
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A drug that increases life expectancy by 1 year is worth 38 trillion? I don’t know, I think Rapa might do that.
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@RapAdmin Good feedback. I think regarding the on and off “switching” there exist some support for handling for this already today and such things will improve even more in the future. The opportunity that I raised is not a short term and easy thing but if it would be solved I think it may be a very interesting company opportunity.
@Olafurpall I fully agree that the research around IL-11 is at it’s early phases. I want to point out that I don’t mean we just create a gene therapy without lots of research behind. I just think it’s a interesting area to start looking at and see what possibilities there exist.
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You need a cat. They’re good for 9 experiments each
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What compound killed your poor dog?
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Here’s the NUS paper
http://www.nature.com/articles/s41586-024-07701-9
If IL-6 and IL-11 are related to inflammation, could similar results come from inflammation lowering protocols such as Bempedoic Acid?
It also seems that IL-11 upregulates MTORC1, so it’s probably working in a similar fashion to Rapamycin. So Rapamycin plus IL-11 treatment may only add a bit more lifespan than either one by itself.
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This graphic from YouTube Shows that anti-IL-11 therapy covers all 4 bases so the other interventions, rapamycin, etc., would be unnecessary.
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Based on a graphic with a couple red down arrows?
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