Inquiry Regarding Rapa, Metformin, Acarbose, and Their Alignment with My Conditions

Hello, I’ve been following this community for a while, and I’m grateful for everything I’ve learned here!

I’m a 42-year-old male with HBP, which is under control with ARB medication. I also have MTHFR, COMT, and the APOE 4 mutation (one allele, still unsure about the other). Additionally, I’ve been dealing with inverse psoriasis for a few years, which remains somewhat persistent despite my efforts. That said, I’m in decent shape :sweat_smile: - quite athletic, regularly training in endurance and HIT, and eating well.

Recent lab tests showed the following:

  • Total cholesterol: 176 (reference: <190) – previously 199.
  • HDL: 59 (reference: >40).
  • LDL: 115 (reference: <115) – previously as high as 129.
  • VES tends to be on the higher end, with values of 24 and 19 (reference range: 1-20) over the past couple of years, despite my supplementation regimen.

I’m currently following a supplementation regimen based on Nutrahacker test results. I’ve been considering starting Rapa, Acarbose, and Metformin, and I’m curious about how to move forward with this plan, particularly in relation to my genetic mutations. Based on the information I’ve shared, I’d appreciate any suggestions or insights on how these medications might align with my needs and my supplementation regimen. Additionally, I’m interested in learning where to source these medications safely (and cheaply) abroad (I’m located in Europe). Any recommended protocol to target APOE 4 would also be greatly appreciated.

Thx a lot and sorry for the long message!

S-Acetyl Glutathione 100 mg
Boron 3mg
Fiseitin liposomal 500 mg
Molybdenum 150 ųg
Pterostilbene 150 mg
Tocotrienols

Spermidine 5.5 mg
NMN 500mg
AC11 350 mg
Pqq 20/40 mg
Astragaloside IV 50 mg
Coq10 1000mg

Mushroom complex
Liposomal c 1200 mg
vitamine D 50 ųg+ K 75ųg

Urolithin-A 500mg
Probiotics 60 million
Cholin trio
Berberine 1000mg

L-methylfolate 1700 mcg/DFE (2 times x week)
TMG 1000 mg
B3 (3 times x week)

MSM 700 mg (once a week)
Cal 1000mg
Mag 400mg
Zinc 15mg

NAC 600 mg
L-glycine 1.5 gr
L-arginina 4500 (once every 2 weeks)
Acetyl-L-carnitine 650mg
Taurine 750mg 1cps
ALA 650 mg

Nattokinase 100mg (2000 fus)
Selenium (200 ųg)
omega 3 1126mg/ epa 670/ dha 330
Noopeptide 20 mg
Alpha gpc 200 mg
phosphatidylserine (150mg)
Bacopa 20:1 400 mg
L-theanin 500 mg

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I won’t offer too much advice because others are far better qualified. But have you tried vit D, vit A and Vit k2 for the inverse psoriasis?

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This is a good thread for you to follow on your APOE4 question

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hello, thx for your reply! I’m on vitamin D and K2 but didn’t look into vitamin A, it seems beta-carotene might be a good option…thx for the lead!

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Hello Beth, thx for pointing this link out it’s really rich! - These are the supplements I take with regard to APOE4,

Spermidine 5.5 mg
Selenium (200 ųg) (every 3 days)
omega 3 1126mg/ epa 670/ dha 330
Noopeptide 20 mg
Alpha gpc 200 mg (every 3 days)
phosphatidylserine (150mg)
Bacopa 20:1 400 mg
L-theanine 500 mg

but I might need to increase omega 3 and spermidine and possibly vitamin D? although I’m also starting to think I’m already taking a lot of supplements and I might be triggering the immune system too much and hence psoriasis? I’m not sure…I might need some testing to figure it out… I’m also wondering if taking Rapa Acarbose and Metformin needs a reduction in my supplement regimen or not…

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I probably know less about all this than everyone else here, so I can’t offer anything too useful, but I’ll say that the overwhelming majority of people on here are on rapa and acarbose (fewer on metformin) and 1,555,883,999 supplements :). You’ll soon discover this.

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I recommend you read this thread: Predicting Alzheimers & Dementia (and minimizing risk)

Also - I would work to simplify your supplement protocol. For example - Fisetin has no strong data behind it. You can watch this video to learn more about senolytics and fisetin specifically:

NMN and NAD precursors, also highly questionable, see this part of the video:

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thx a lot! Incredible resources, I’m digging them…

on another note, I saw that recently Rapa seemed to perform badly on several clocks and I probably missed a thread about that on this forum? It seems that it didn’t concern anybody here so I’m sure there’s some flaw in the assessment of the drug’s effects on those trials…?

Right, no concern about clocks. Also: the value of the clocks themselves hovers around zero. If you listen to that yt video RapAdmin posted above, this is extensively discussed. It really pays to explore the resources provided, because they answer many questions one might have. Good questions, though!

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Yes - see this discussion: The Effect of longevity interventions on epigenetic clocks (BioRxiv) - #9 by Neo

also this one: Bryan Johnson stops rapamycin

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One thing I would be concerned about is your cardiovascular disease risk. Your cholesterol seems towards the high end and you may want to consider something like Bempedoic Acid and Ezetemibe (1 pill). They can be cheaply and easily ordered from India.

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Hi, to boost your immunity to combat the inverse psoriasis, you could consider injectable gluthatione,
it costs 44 euro in Italy and my pharmacy in Belgium can sell it to me at the same price;

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With your inverse psoriasis and increased cardiovascular risk with that diagnosis alone, combined with elevated LDL and HTN, I would think about adding a statin.

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This looks really interesting especially as my supplementation didn’t seem to replenish enough my gluthatione levels - I didn’t proceed with that idea yet cause I need a nurse to inject it for me and probably a prescription to get it…but your input revived the idea and I think it’s one of the right thing to do so thx for bringing that up!

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Thx for this - I’m reading about statin and ezetimibe and it feels that the latter might have less side effects and achieve the same results…? In anycase I’m
seriously considering adding metformin and ezetimibe now to my protocol, I’m going for some blood test next week and track my glucose levels with a glucometer starting tmw and figure the next steps in terms of ordering those meds from India if I can’t get them prescribed here in Italy…

All your replies have been really helpful and motivating and I’m grateful for all of them :pray:

You could also consider this if you what to avoid getting a prescription / nurse for the injection;

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You can overdose on glutathione, so I prefer to take the precursors, glycine and NAC, and let my body produce as much glutathione as it needs.

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After supplementing with 500 mg-1g of liposomal glutathione, 600 mg NAC, and 3 g glycine daily, beside everything else listed above, my GPX levels came back low at 21.2 (reference range: 76-904). Meanwhile, my GR was 100 (range: 12.7-487), suggesting my system has an hard time to both absorb GR and convert to GPX (expected) despite supplementation.

Given this, I’ve switched to 100 mg of S-acetyl glutathione to replace my questionable-quality liposomal glutathione, though I’m pretty sure this dosage may be too low for my needs. I’m testing my levels again at the end of the week and considering IV or suppositories to boost levels before figuring out long-term maintenance.

Meanwhile testing my glucose levels to probably move forward with Metformin…

Thx a lot for your input! Will keep updating…

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Like everything, it needs to be balanced accordingly. A doctor told me that before the “no needles policy” in cycling, cyclists in the Tour de France, used 600mg every day ( so 22 days in a row) with great succes

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I use a brand called Bempetol-EZ that combines the two (Bempedoic Acid 180mg + Ezetimibe 10mg). Generic version of NEXLIZET

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