My partner registered an astounding 21 years younger on aging.ai but only 6 years younger using Levine. I think it’s because their cholesterol scores are very low. Aging.ai uses cholesterol and Levine does not.
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aging.ai does not even include homocysteine…
I don’t know why Levine does not use cholesterol… Cholesterol generally increases with age - HOWEVER - I know that CRONites like the livingthecrway.com one see no increase w/time (just as they don’t see an increase in blood pressure).
My guess on the increased validity of CRP and RDW is that they are the downstream integrators of A LOT of upstream age-related factors (yet even then I’m sure there are some aged people with ultra-low CRP - I just don’t know who they are)
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As Richard Miller stated in his last video about epigenetic age tests:
A woman gets pregnant - she gets older
A woman gives birth - she gets younger
A person gets sick - they get older
A person recovers - they get younger
A student has a test the next day - they get older
A student gets good marks on said test - they get younger
Are epigenetic tests really measuring age or are they measuring homeostasis?
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Is right on this forum, member “Agetron”
And the proof is in his biomarkers.
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Hahaha - well thanks as an early adapter (and before finding this group of amazing members and advice), I am probably one of the earlier users at 2 years and 3 months now. Lucky to have a GP that works with me and not afraid to try something. Especially knowing the benefit/risk ratio is so minimum in side effects of a drug used since the 1990’s on some of the sickest people - organ replacement.
Also, not wanting to offend anyone - just my perspective, I believe having started getting in shape at age 59 years (see pic below of fat me) and then starting rapamyin in my early 60’s (pic of me now). I probably see benefits as being in the age group where we are just at the point of functional decline - tettering so to say. I think those in their 50’s are still a bit young to actually see all the benefits (like Matt K. and Peter A). And, those in their 70’s and 80 can benefit - but have already crossed a bit deep into the decline. I think they are benefiting too - just a lot further down the path so not as much can be undone. Again, just my personal observation and from seeing and reading self-reports here. Sure I wish I had started rapamycin at 50 years. Glad I did start at 62 years. I truly see and feel benefits in body tone, skin, memory, euphoria, blood flow, no arthritis or pain, strength and muscle growth, loss of visceral fat… loss of all extra fat - shredded now, so much - everything is as it was a decade or more ago. I am at that inbetween point 50 yrs. to 70 yrs. to truly see huge benefits. Talk is talk - the proof is in the photos. Also, understand I am not a gym rat or diet freak - I do one hour 15 minute workout mostly on machines every other day for past 6-years. I am an omnivore - like it all and eat a lot of food - protein and whole milk dominate my diet. Normal guy here.
Just want everyone to do as well as me. Trust me I am a pretty average guy. And a bit lazy about my health. Afterall, look at me at 59 years in the pic - haha. Typical to a fault. I definitely could do a lot more - but that is work!! But meh! I prefer my little rapamycin pills. LOL. I want to live long and healthy to enjoy my family, friends and lots of learning. Good journey!
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Well, congrats on your age reduction. I’m really glad you feel this way with rapamycin now. It’s still the case that “younger is better” b/c if you start earlier, you slow down ALL the age-related damage earlier (different types of damage “synergize/accelerate” other kinds of damage and mess up repair earlier), so the most “age reduced” person is most likely someone who started much younger.
I’ve observed that genetic hetereozygosity in the population is still large enough that the most clearly age-reduced people don’t seem to be doing “anything super-special” compared to the CRONites I know…
It’s also possible (JUST by pure statistical properties in the human population) that those who are most responsive to intervention might not be the same set of ppl as those who intrinsically age much more slowly… (centenarian smokers are the easiest subsection of the latter group)
FYI I know OF someone who had their epigenetic age reduced by 20 years following exosome therapy, and just appears as sickly as before…
A Friendly, Biological Age Reduction Competition? - #61 by Agetron => proof that he doesn’t have the best rate of intrinsic aging (yet anyways)
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^This is the grandlist of omics/“biological age clocks”
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Absolutely, I think the younger you start the better off you are which is why I’m glad my son who is 32 years old has started weekly dosing at 2 Mg.
The problem is after 6 months he tells me he doesn’t feel or see anything different, nor should he at 32 years.
No doubt he’s getting the benefit… however, he is not seeing the subtle little differences that will make the big difference in the long run.
Just hope those on here under 50 years can understand and have faith in this amazing, natural microbe.
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The problem with preventative medicine is that you won’t see and feel all the diseases you avoid getting! Keep the faith that it is good for you. For us older folks, we can see and feel the effects. I just hope it’s not too late for some of it…
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EXACTLY!
We are here and it works. Because issues are reverting and resolving.
Keep to the plan youngster (lol) and at some point you will realize you are holding or only slightly moving forward in age. Wish I had this at 40 or even 50… but glad to have found it and started at 62!
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Hi, apologies if I missed it but what dosage protocol for rapamycin are you on (and metformin?) And do tou take with oil/grapefruit?
Many thanks in advance
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In the same way epigenetic tests work across large populations, with a single person you’d likely need to test repeatedly and plot a moving average. Any one snapshot in time would probably be too influenced by the type of changing factors you mentioned.
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Exactly jakexb.
My biggest regret on biological testing is that I did not have the foresight - 2 years and 4 months ago before I started on rapamycin - to do a baseline measurement. I waited a full year to see if I was getting a benefit… first with TruMe and later with GlycanAge. The staff at both companies were surprised by my biological age results.
I do have my TruMe genetic spit methylation results for 1 year use and 1.5 years use. My 3rd test will be back in 2 weeks and I will post all 3 test in a linear fashion for everyone.
Also, I did my first GlycanAge test after 1.5 years of rapamycin use… and have my second test currently at the GlycanAge lab. So, in 2 to 3 weeks I will post those up too.
I will be able to see if higher dosing of rapamycin 30 ng/mL for the last 7 months has moved my biological age for better, worse or no change at all. Can’t wait!
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Excited to see your new results. I’ve only done one 8 week cycle on rapa for myself and my dog.
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From reading many personal accounts of many rapamycin users. Most using report… they don’t notice major changes until the end if the 3rd month. That was my experience too.
So be patient.
Definitely excited for latest results.
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Dude you don’t even look like the same person, wth
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@Agetron is our rapamycin posterchild!
If we were a commercial site like weightwatchers.com we’d hire him and put is before and after images on the home page 
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Phil wrote: Dude you don’t even look like the same person.
Hahaha… I get that a lot… only 6 years difference. One of the medical university students at the school gym tonight told me … you look 50 years … I will take it… I told him to come to this site. He seemed impressed.
TBH…I dont feel the same either… got my 30’s attitude, swagger and constant euphoria… must be on rapa ecstasy. Lol.
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Where did you say you sourced your Rapamycin from again??? 
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