When imeglimin is combined with metformin, the incidence rates of diarrhea and nausea reach as high as 15.6% and 10.9% respectively, which is significantly higher than with monotherapy or other combination regimens.
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From my perspective (an obsession with mitochondria and acetylation) it arguably would reduce ROS which reduces the creation of deletions in mtDNA, it also would improve â¨ÎΨm⊠which would improve gene expression. However, it would act as a prop rather than encouraging mitophagy (and particularly fission-mitophagy-fusion). Hence it looks like something worth taking with Rapamycin, but not something that would replace Rapamycin.
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Imeglimin, especially in combination with non-Metformin OHAs, improves glycemic control and reduces mitochondrial and inflammatory stress in T2DM patients. These findings support its use as an adjunctive therapy with broader metabolic benefits.
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Please, share your experience how you mix antilipids medications? What dosages, and what numbers youâve got and achieved with them. Really important info, thanks
Hi @egorvj, thatâs a lot of data I would have to gather. But, I already did that in 2025, I had several blood tests every few months starting April 2025:
and then every few months, June, August and so on, with details on all the LLT drugs, their individual and combined effects, all experiments on myself.
If you go to that thread âCardiovascular Health 2025â, and look for my posts, you will find all the details - itâs too much data to recreate for me here, but go through that thread starting with the April post I linked to above, and then go through the rest of that thread to find my detailed posts. Good luck!