Longevity and health wise, if I really just have to choose 10 and 10 only
- Creatine, 5g a day
- Collagen 20g a day
- Taurine 6g a day
- Glycine 6g a day
- Ergothioneine
- Lithium orotate
- Mg bisglycinate
- A D3/K2 mix
- B9/B12
- TMG 2g a day
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I had GPT-5.5-thinking pool together everyone’s list above and reason about which from the lists would be its “top 10” pick, and it gave:
- Creatine monohydrate
- Vitamin D3
- Magnesium
- Psyllium husk
- Omega-3 EPA/DHA
- Glycine
- NAC
- Taurine
- Lutein + zeaxanthin
- Berberine / dihydroberberine
I’d probably draw up a different list, and would focus on combinations like “magnesium glycinate” and “potassium citrate”, that way you get several compounds in one.
Addendum: I asked it which ones it would add that aren’t on anyone’s list, and it came up with Cocoa flavanols / cocoa extract, Vitamin B12, iodine, potassium-enriched salt substitute, Resistant starch or inulin-type prebiotic fiber, a strain-specific probiotic.
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I take all of those except ergothioneine. Aside from the longevity benefits, what are you expecting from that? Which product are you taking?
i just put my genome into Claude and asked it for my personal/bespoke list. Very interesting top 10 and very different to a standard top 20 list. Ive found the logic much more compelling for my bespoke, genomic-supporting list
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Did you submit the raw datafile or a report?
Likely not an issue but the gene expressions that would suggest moderation in glycine consumption are not rare. Have you checked your profile? Also, a few of these supplements, especially at these doses, present a load on the kidneys. I assume you are young and have high kidney function.
Every model that I have tried so far includes metformin in the top ten.
It’s because without looking at the genetics, people can assume it works. In my case metformin has never done anything to reduce my glucose but now, after all my deep dives in various genetic pathways, I know why:
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My top list ranked by genetic impact is very far from those generic lists.
I was quite surprised to find out that sulforaphane and NAC are my 2 most impactful supplements.
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THC gummies 10 mg, 3x/wk
Retatrutide 0.5 mg/wk
Testosterone gel 1 packet/day
HGH 1.2 iu/wk
Sodium citrate 2 tsp/day
Tributyrin 800 mg/day
Curcumin 500 mg, 2x/day
Iron bisglycinate ++ 26 mg/EOD
Lactoferrin 600 mg/EOD
Ergotheioneine Just added
yes. Claude’s response specific to me focussed on TMG, choline variants, creatine, magnesium variants, glyNAC and rapamycin. and optimized b12 and folate.
Most of these i was getting anyway - but using claude has encouraged me to be more systematic on particular supplements.