I think the main benefits of HBOT arise from HIF activation. I don’t think Hyperoxia has any benefits beyond that.
1 Like
The influence of CO2 on up regulation of hypoxia related genes.
“ Because nasal breathing prevents hyperventilation during exercise, it promotes an increase in the partial arterial pressure of CO2. The rise in systemic CO2 stimulates hypercapnia and permits the upregulation of hypoxia-related genes.”
2 Likes
I thought the main use for HBOT was its potentiation of radiation(oncology) therapy, and wound (burn) healing?
AIUI it is mainly about HIF-1α
1 Like
It is common practice to provide it in Korea after surgery.
1 Like
Can you share more about that?
Have we discuss this piece
And/or
https://x.com/bryan_johnson/status/1902044120807567436?s=46&t=zJMJ1xVdRJYEDYz-DHipTw
1 Like
Thank you for the question. I dislike sending out the wrong information. Dr Erfati serves as Chair of Aviv’s Medical Advisory Board and is the founder of and closely involved in the operations of Aviv Clinics, which offer advanced HBOT protocols. But now, when I look at it again I can’t find information that he is investing his own money in clinics.
Hyperbaric Centers - Hyperbaric Oxygen Therapy near me
Summery: Dr. Efrati has helped establish and direct clinics that offer these therapies,
2 Likes
I enjoyed this basic and optimistic video from the aviv Longevity Symposium. Maybe not much new information for a biohacker, but he is good at presenting advanced therapies to the public in an understandable way, and he threw in some perspective and comments that I enjoyed.
Dr. Michael Roizen, Chief Wellness Officer Emeritus at Cleveland Clinic. Founding Chair of the Wellness Institute at Cleveland Clinic and Auther of the book “The Great Age Reboot”.
Adding on—
The mechanisms behind HBOT seem to hold water. Intermittent hyperoxia triggers pathways we typically associate with hormetic stress: elevated VEGF, stem cell mobilization, mitochondrial shifts, SIRT activation.
So yes—it can probably nudge someone from 90 to 92. In Johnson’s case, that delta is plausible (though worth noting he was stacking other therapies during HBOT).
But that doesn’t mean it takes someone from 20 to 90.
The delta it delivers depends entirely on the boring foundation: plant diversity, inflammation status, glycemic control, microbiome diversity. If those aren’t dialed in, the ceiling on HBOT’s benefit is, in my opinion, likely fairly low.