“…hypoxia inhibits mTORC1 in part through AMPK activation, but also through the induction of REDD1 (Regulated in DNA damage and development 1), which activates TSC (
)”
I thought this was interesting…a reference from this paper: mTOR Signaling in Growth, Metabolism, and Disease: Cell
HBOT has been on my radar for some time. I finally broke down and went as a holiday gift for myself. I went because I have some stubborn tendonitis and pain in my legs/hips/lower back. I also had Lyme disease previously which apparently doesn’t like oxygenated blood. I went to a local provider with a real industrial dive chamber taken from a diving vessel. Location
The center starts you at 1.5ATA for 60 minutes. I climbed into the chamber. They pumped in air pressure and i had to unplug my ears a few times, like in an airplane. After that I sat there for an hour, reading and meditating. Easy.
For the remainder of the day I felt great. Clear headed and joints, muscles seemed better. Who knows if this was placebo but I am going to try it again. $150a session, not bad.
I needed a Dr’s note to try it. Just asked him to approve me going to 2.0ATA depth since I tolerated 1.5 no problem.
HBOT’s increase in free oxygen radicals would likely decrease longevity. Most of the papers with HBOT appear in cancer treatment, where the increased generation of free radicals increases the effectiveness of radiation treatment and some chemotherapy agents.
Don’t think Bryan Johnson would be doing as aggressive a HBOT protocol as he is or seeing the results he is if it was known to be bad.
I don’t think bj is the font of all wisdom, but HIF 1 alpha is a useful nuclear factor
Yup for sure. In his link he sites a lot of good research though to support his trial.
Interesting interview. He is also an investor in HBOT clinics so he might be biased. But he explains the theoretical background and the protocoll.
I was considering Hyperbaric Oxygen Therapy, but this study, showing it may have negative effects on the gut biome, tipped the case against it for me, together with the fact that I get one of the goodies of HOT, immune strengthening, for a fraction of the cost and time with peptide Thymosin Alpha 1.
There is a lot of debate about the mechanism of HBOT. I purchased a liveo2.com adaptive contrast system that I can cycle between very high O2 (85+%) to very low (10%) and do this while exercising (EWOT). Seems like this will create a large hormetic effect between hypoxia and hyperoxia states.
How long have you been using it, how often and for how long?
I ask this, if you considered in you N=1 experiment testing your telomere lenght before and after 90 days, to evaluate if the stimulus corresponding.
Fabio
The key thing about HIF is that it results from a change (reduction) in partial pressure of oxygen.
just started - did get a trudianostic age test before starting so will look again in a few months
You can get faster feedback by tracking your sleep breathing rate. Lower rate means more co2 tolerance. Nasal breath while sleeping also helps.
Paul, your home experiment feedback is extremely valuable, i’m cross-referencing your feedback on my other attempt to achieve a similar oxygen playground but while sleeping, it would be way interesting to come up with some data on effectiveness on telomere length (that’s a way known benefit of HBOT alternating oxygen protocol at 2ATA), but without expensive/dangerous/complicated HBOT device.
Are you also tracking your VO2Max? I’d be interested in pre and post testing for that…
in a way. My Oura ring has a 6 minute walk test that provides a VO2 max number
