I have 500 mg of high purity Rapamycin from Science.bio.
This equates to approximately 0.0176 oz a very tiny amount to handle.
(Related: Powdered Rapamycin from Science.bio)
Need
I need a way to readily work with such small amounts to prepare:
- Topical Minoxidil + Rapamycin
- Rapamycin face|skin cream
- Toothpaste + Rapamycin
Transcutol?
My initial thought, dissolve Rapamycin in Transcutol to give me a volume of liquid more readily used and measured without high precision instruments.
I would, as example, want to add 10 mg of Rapamycin to a batch of any of the three use cases.
For context I currently add 10 mg to a month’s supply of toothpaste and topical Minoxidil, but currently I use Rapamycin powder from a compounding pharmacy than must have a huge percentage of fillers.
Process
The process seems straight forward as Rapamycin has a high solubility in Transcutol, (approximately 144.8 mg/mL).
To dissolve 500 mg of Rapamycin, it looks like I would need approximately 5 mL of Transcutol to achieve a concentration of 100 mg/mL and amount well below saturation.
To add 10 mg of Rapamycin to a batch, I could use 0.1 mL of the 100 mg/mL solution.
Questions & Considerations
- Does the above make sense?
- What about stability and compatibility with other ingredients?
- Any concerns about Rapamycin pH and Transcutol?
- Do Rapamycin formulations require a pH below 6 to maintain stability?
Input appreciated.
