Which by the way is much lower than the 0.2 % or more typically sold online. For example gethealthspan sells 60 gm tube of 0.2 % or higher and one is supposed to use that over 90 days.
0.2% of 60 gm = 120 mg of rapamycin / 90 = 1.3 mg per day or 9 mg per week.
I know it’s topical and it’s supposedly poorly absorbed but it just seem like a big dose to use just on the face.
I noticed the word “paiva” and the word “polynucleotide” several times in this thread and I wanted more information. With a bit of research there seem to be some PubMed studies, but I also found this very current article in Harpers Bazaar. It’s very readable (maybe 10 minutes) and interesting. Apparently, injected polynucleotides can cause the skin to undergo some rejuvenation. I would like more information about safety and how long it lasts, but did not find that. How it would compare to laser treatment or retinoids would be nice, too, but I found nothing there.
I was told the effect should last about a year. I had this done few weeks ago, did not research in depth, but the result is really natural, it is not a filler, skin appears plumper and younger looking. I would say it gets a better texture. The best I can describe it is similar to using instagram filter. It does not change you, but you appear somehow younger.
One interesting aspect of the genome is how the non-coding DNA acts as a form of metabolic logic and makes decisions for the cell without actually producing proteins.
Clearly this goes wrong in the same way as other aspects of transcription and that can affect other things. It could affect the way the cell deals with nutrient availability. I probably should read up on this at some point.
Would you know (off the top of your head — i don’t want you to be my librarian) if TOR not turning off when eating excess nutrition is just due to excess nutrition which leads to metabolic misbalances (high TG, high BG, etc) or does it happen when larger amounts of amino acids are provided (let’s say hydrolyzed plant-based amino acids so we don’t get potential/perceived “issues” with animal protein). Or perhaps TOR being on “excessively” may not be an issue when involved in recovery and muscle building? I ask because i see a number of older natural body builders and athletes (who haven’t destroyed themselves like football players) who look fantastic for their ages (obviously not a Clinical research trial or MR) — are they actually aging faster but the visual impact of muscles make them look younger?
So, in effect, you’re asking what nutrients or other factors are the primary activators of mTOR and what is their relative contribution to aging - would that be a correct characterization of your question.
I’ve not dove too deep into this but if you search on “mTOR activation” or “mTOR activators” in our forums we’ve had many conversations around different aspects of this topic. Dudley lamming (formerly of the Sabatini Lab) has research suggesting the iso-leucine is one of the major activators of mTOR, see this video (and thread): If Validated This is Huge News on Leucine -- A Paradox Solved? - #4 by AlexKChen
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I use topical finasteride and it is producing some good results. My concern about taking finasteride is the side-effects. Has anyone had any side effects from taking finasteride?
When I fist started using oral finasteride in late 30s, I was expecting the reduced libido per typical listed side effects. Just opposite happened. It couldn’t have been placebo because it was unexpected. I felt like a teenage boy again. I had to cut back the dose to 0.5 mg because it got to be too much.
So now at 50 I am increasing my dose back up to 1 mg again because first signs of urinary issues. So far so good.
My theory on why some people get decreased libido with finasteride goes as follows. I suspect that obese men are more likely to get it because and I quote
In obese men, the increased expression of the aromatase enzyme in adipose tissue leads to high conversion of androgens to estrogens contributing to hypogonadotropic hypogonadism (HHG)
We know that blocking 5 alpha reductase will actually increases testosterone and thus providing more substrate for the conversion. Having about 12-15% body fat (I was 10-12% before) it didn’t seem to be an issue in my case.
Yes. He seems to know what he’s doing. I think this is one of the better treatments out there as it removes skin and tightens the skin without surgery. just a shame it’s so expensive. To see the best results you need 2 or 3 treatments.
Well depending on the treated area, CO2 laser can give you great results and sooner. That said it doesn’t go so deep. So I think the doc mentions doing the combo of laser and Ellacor. And yes I believe such procedures are expensive and for sure you need more than one treatment to get full results. That said my take on it that there is a value. It would be great and better to have some systemic process to fix all aspects of aging. For now there isn’t. I have been taking high dose Rapa (10 mg once a week) for the last 5 years and still have to do supplemental treatments to get the best results.
I agree that it’s worth doing. It’s just out of my price range right now. I prefer something like Ellacor as it actually takes out skin, so you’re shrinking the surface area. The downtime is also pretty short.
If money was no object I’d have already had 3 treatments. I think this will become popular and I had hoped it would bring the price down but if anything it’s going the other way. Plastic surgeons to love to price gouge.
You might look at pricing and availability in Europe… Spain, Portugal, Italy, Turkey… their prices (from what people here tell us) are a fraction of the prices in the US. Tie it in with a summer vacation…