I don’t dilute it, it already has lidocaine in it. Use it on jaw line, chin area, marionette lines, and hands by sharp needle. Works well.
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“Live fast, die young, and leave a beautiful corpse”
Should be
“Live fast, die old, and leave a beautiful corpse”
That’s my goal LoL!
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FYI dermoelectroporation will NOT work with undiluted radiesse as it’s too viscous and “chalky” — almost like cement. It has to be diluted at least 1:1 to work, but for me the 1:1 semi dilution does provide some subtle volume.
What can be used straight up is Sculptra, which is very watery when properly constituted. I think anyone in need of volume above all else should prioritize Sculptra over Radiesse.
I wouldn’t self inject either under any circumstances because I’m not competent with injection and don’t want to learn on myself. But more power to those who know what they’re doing. To me the dermoelectroporation replaces the need for a skilled injector but it DOES require good knowledge of the materials being used, what can and can’t go where.
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I was not talking about demoelectroporation. I’m very familiar with the product (have been using it for over 15 years). I use it in the original form with lidocaine. There are 2 types available, with lidocaine and without. I buy the one with lidocaine. If applied correctly, it’s very smooth and lasts long. 1.5 ml (1 syringe) is enough for the my lower face and the same amount covers both hands. 2 syringes, 1.5 ml each, cost approximately $300 with delivery. If you choose to do it professionally, the cost is usually $600+ per unit.
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So people using it with electroporation devices would not, I assume, need the lidocaine?
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Here’s something interesting about skin I learned a while ago:
Scar tissue is composed of the same protein collagen as the tissue that it replaces, but the fiber composition of the protein is different; instead of a random basketweave formation of the collagen fibers found in normal tissue, in fibrosis the collagen cross-links and forms a pronounced alignment in a single direction.
So, the way collagen fibers are arranged is partly to blame for the presence of scars. Is there a way to physically alter the arrangement? It seems maybe “yes”:
Mechanical, structural and chemical guidance cues have all been shown to regulate alignment of fibroblasts and collagen in vitro , and prior studies have proposed that each of these cues could regulate anisotropy of infarct scar tissue…
What about the effects of vibrating plates? I have tried those at gyms before (some LA Fitnesses have vibration plates), and then later read that they may affect the structure of skin – e.g. tightening it. I was mostly interested in the effects of these on muscle, since I had heard they can give you a workout without a lot of effort (basically, the plates move your body a little, and your muscles try to correct, to maintain balance; and these constant corrections work the muscles); but then I had also read that they might increase collagen production, maybe even tighten skin. Here is one that shows potential benefit in women with cellulite (thankfully, men don’t get cellulite, as our collagen fibers are different):
In the regression subgroup cellulite returned to initial values soon after cessation of treatment, whereas in the continuous application subgroup, cellulite remained diminished.
(Authors declare no conflicts of interest.)
I have also read that they can help with lymphatic drainage, which can further improve the appearance of skin.
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They’ve also found another way to minimize or eliminate scaring…Verteporfin for Scar-less Skin Repair, and Hair Transplant Growth
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Yes, it’s correct! It’s a little less expensive than the one with lidocaine.
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It’s interesting but I never tried that.
I asked a friend who professionally works with Radiesse about diluting it with CytoCare or another HA based product instead of saline or lidocaine. She said it could be risky. Then I double checked it with AI and got the following:
Standard Dilution Practice
Radiesse is typically diluted with:
• Sterile saline: for viscosity reduction
• Lidocaine: for patient comfort during injection
These diluents are inert, well-characterized, and maintain the integrity of CaHA microspheres, which are responsible for collagen stimulation.
What About CytoCare?
CytoCare is a hyaluronic acid-based mesotherapy cocktail containing vitamins, minerals, and amino acids. While some practitioners experiment with combining it with Radiesse, this is:
• Off-label and unstudied by Merz
• Not supported by formal compatibility data
• Potentially risky due to unknown interactions between CaHA and HA complexes, preservatives, or bioactive additives
Risks of Mixing with CytoCare
• Chemical instability: HA and CaHA have different pH and ionic properties
• Microsphere dispersion: Additives in CytoCare may interfere with CaHA scaffold formation
• Unpredictable tissue response: No histological studies confirm synergistic or safe outcomes
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I did a similar search and saw similar warnings. What overrode me was seeing a practitioner mention he’s been experimenting with using NCFT 135ha as a solvent for Radiesse and getting better clinical outcomes with his patients than when using saline. So I tried it with it and loved the result. One time I was out of NCFT 135ha and used Cytocare. Still got very good results, but I am a bit biased towards NCFT 135 ha — it seems to agree with my skin a bit better generally. My interpretation of ChatGPT’s similar warning to myself was that it’s being conservative because the combo hasn’t been officially studied by Merz. It stands to reason they’d want to keep their studies and recommendations simple as they can’t predict the outcome from all sorts of reactions that might or might not happen between the hydroxilapatite and any of the components of these cocktails. So your mileage might vary. I’m very satisfied with my results so I’m tipping off anyone who might want to try it, that in my experience it works well. Of course the most standard and safe way to use it is simply with saline.
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Oh, one thing I forgot to mention was that scars are more than just a curiosity to me. I recently had surgery, and have scars on my head, near my left ear. Fortunately, they didn’t cut my hair, or else I’d look like part Frankenstein on the left side (it’s apparently not uncommon these days not to cut hair for certain kinds of head or brain surgery); though, the length of the scar is small. My hair is fairly thick, so it masks the scar almost completely.
About a week ago, I was talking to my department head, and he said, “where are your sutures?” Almost like he didn’t believe I even had surgery. I had to pull the hair back from my ear so he could see the staples – and those staples were cut a day after that, and they kind of broke apart. So, it’s even less visible than it was before.
I had a haircut today, and I told the woman cutting my hair not to be alarmed by the scar near my ear, and explained that I had had surgery. She tried to be extra-careful when cutting that part of my hair, so she wouldn’t injure me.
Given the rate of healing and progress, I wouldn’t be surprised if in a month or two, my scars have healed almost completely, and that you would never even know I had surgery, even if you pulled back the hair and looked very close. I fell like I’m kind of lucky in that regard.
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@medaura I’m looking into this DEP device. It looks very promising (i was allways scared of needles 
) and I’d love to learn more. I couldn’t find the manual on Scribd or anywhere else; could you share it (link or file)? Also, a few of the Alibaba links from your earlier posts in another thread no longer work. Is Annis Dang still your contact? Probably she is best to inquire about prices/shipping etc.
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Annis is who I buy the products to use with DEP from. But the device itself is from Dennis Ma, with this WhatsApp contact. Ask him for the DEP device and he can whip up a purchase link
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Good thanks! I’m already writing him as I write this
If it’s really around $200, it’s a no-brainer.
If you have the original manual, I’d be most grateful too.
PS: One hour later. Ordered it 
It was 200 euro including shipping and optional consumables. Your contact is really efficient and quick.
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Oh he can send you the manual in pdf form but unfortunately it’s more like a marketing brochure than a manual. To see how to use it just watch that webinar @RapAdmin linked to. Basically use level 3 on the face, if you can stand it (the weird electric current feeling) and 5 on the body. It’s also highly recommended to exfoliate prior to remove dead skin cells and make it easier for the compounds to penetrate. I use a cheap microdermabrasion kit from Temu, but when I’m in a hurry just go for a good makeup removal wipe. You’ll see there’s nothing to it once you play with the DEP — very easy to use.
The manual I mentioned was for the ultra former MPT — I found it there so I can have precise settings.
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So, although I know there are various good methods for fixing scars, I was still was interested in understanding how some standard methods that some dermatologists recommend – like silicone gel – work. It just seems to run counter to the fact that scars are about disorganized collagen fibers. Apparently what happens is that (according to a Google search) following an injury, the skin loses a lot of water; this water loss triggers keratinocytes to release cytokines; these cytokines, in turn, induce fibroblasts to produce excessive collagen; and these create disorganized fibers. Putting silicone gel over the scar stops the water loss, resulting in diminished signals to produce collagen; fibroblasts respond. Then, on top of that, silicone somehow influences growth factors; and a balance between fibrolysis and fibrogenesis is restored; and so scar flattens.
I don’t think it works well on regular skin (non-scar), though, to “de-age” it.
…
I thought a little about that (de-age skin), also. It seems to me that what I keep hearing about “collagen” and “fat” and the other things don’t help you understand what the real problem is. Here are two (there are more) that are key: (1) You’ve got the 3D structure of skin organized in a way that looks “old” or “cellulite” or whatever; and (2) The skin is too pliable or “jiggly”. These can probably be fixed using some simple methods. e.g. the second one you can fix by just laying down a checkerboard pattern on the skin, e.g. using some kind of invisible gel like silicone; but you’d probably want something stronger. The vertical lines would make it hard to move the skin horizontally, and the horizontal lines would make it hard to move it vertically. That would make the skin no longer jiggly. And, in fact, there are skin products with “film-forming agents” that achieve a similar end (and, for example, temporarily eliminate signs of “turkey neck”).
Oh, wow. I had no idea Rapa effected that!
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Thanks! Can’t wait to try it should arrive in about a week.
How often do you use yours?
You mentioned hyperdilute Radiesse. I’m guessing it also works with a range of skin boosters, right?
Do you have a picture of what you have ordered to share?
Yes, @LaraPo. It’s essentially the same device @medaura has been using for a while, since the summer, if I’m not mistaken.
I did some preliminary research (bought it before I could dig deeper) and it seems promising. I’m still unsure about the hyperdilute Radiesse claim as CaHA spheres may be too large to penetrate the skin even with DEP, and I’ve seen anecdotal reports plus some before-and-afters that don’t disclose they combined injectables with DEP clearly so it might be misleading. I’ll definitely test it with other products. I have a range of injectables on hand, but I rarely use them because I’m squeamish about needles and pain. I also read you can infuse plain lidocaine beforehand more invasive procedures to numb the area more effectively than topical cream. Will likely try that .
DEP说明书(1)_compressed.pdf (6.9 MB)