Has anyone taken Descovy for any length of time and had positive measurable results?
It’s no more expensive from India than some of the common supplements that I take. It is a drug if taken must be taken for life to achieve maximum results.
Gemini Pro 3.1:
Do the Benefits Remain After Discontinuation?
No. The geroprotective effects are entirely dependent on continuous use.
Descovy does not permanently edit or silence the genome; it acts as a chemical blockade. The active intracellular metabolite (tenofovir diphosphate) physically binds to and inhibits the reverse transcriptase enzyme utilized by LINE-1 retrotransposons.
If the drug is discontinued, intracellular drug levels decline, and the reverse transcriptase is freed to operate again. LINE-1 will resume leaking cDNA into the cytoplasm, the cGAS-STING pathway will detect the anomaly, and the resulting sterile inflammation will return. To maintain the reduction in biological age markers, the molecular suppression must be continuous.
As an FYI - if interested in trying this medication - Descovy for all its benefits, it is available as a prophylaxis and a prescription can be received through your local Planned Parenthood Office.
Since any sexual encounter (male or female) contact even in an assumed monogamous relationship - has the potential for HIV, anyone sexually active could request to be put on it.
Medication cost is approximately $2,500 for a 1-months supply. One pill daily. significantly more expensive thatn Truvada - Descovy is easier on your bones and kidneys.
Jeez, that’s if you’re a man getting anal sex though. I guess you can claim to be. Not sure what a woman can claim. Unless we claim we like anal sex from promiscuous partners.
Ummm… men and women can get and transmit the Aids HIV virus. From unclean drug needle use, unprotected sex, non-monogamous cross infections.
I met a woman in my wife’s high school graduation class who contacted HIV/Aids from her husband. She passed away a year after I met her. Unfortunate. I am pretty sure she had no butt sex. My point being you can catch HIV/Aids from multiple means. Planned Parenthood understands this and will assist you in being protected.
Prophylaxis could have prevented her being infected.
TBH… not wanting to be cynical, but with sex and dating and bi-sexual being accepted. If I were 20 again… could I trust any sexual relationship as being up-front and safe. Have to lean toward no.
Back in my 20’s, I’ll never forget my first day of work when the office was almost empty.
That day happened to be the funeral of a young woman who was a rising start at Merrill Lynch. She was engaged and her fiancee cheated… gave her Aids … killed her…
It actually changed how I look at cheating. Most people say it’s better if the other person meant nothing to you. I feel the opposite… if you risk killing someone, I certainly hope you at least loved that person!
Hey All:
I did a little research and the cost difference between Descovy the better medication with longevity and Truvada is almost $2,000 more per month - ouch! With insurance that becomes $100 per month. Longevity benefit is not cheap - it seems. See below
Generic Truvada (emtricitabine/tenofovir disoproxil fumarate) is significantly cheaper than brand-name Descovy (emtricitabine/tenofovir alafenamide).
[image]GoodRx
Generic Truvada: Costs around $50 to $100 per month with discounts. It also has low-cost options through programs like Ready, Set, PrEP. No longevity benefits unfortunately - it acts differently in your body.
Brand-Name Descovy: Costs about $2,000 to $2,300 per month without insurance.
[image]PridePoint Health +4
Generic Truvada is usually the most budget-friendly choice if you pay cash. If you have insurance, many commercial plans cover both medications. This can bring your out-of-pocket cost down to $0.
[image]Aidsmap +2
Truvada and Descovy are medications used to prevent HIV (known as PrEP).
[image]GoodRx +1
Truvada uses an older, proven formula.
Descovy is a newer formula. It is designed to be gentler on the kidneys and bones.
I only said that because when I looked up the claim that anyone could ask for it as a prophylactic against HIV so long as they were sexually active, Google basically told me insurance would only cover it in high risk populations, which were pretty much exclusively defined as butt fuckers.
Oh I see now… well yes of course - if it’s on Google or the Internet it must be true! Hahahah!
“Insurance would only cover it in high risk populations, which were pretty much exclusively defined as butt fuckers.” Or needle drug use… or sexually active. TBH - how do they know how high risk you are or are not? Does Bi-curious count?
Just messing with you.
However…
The next question - what would you pay for 6.33 more healthy years?
Or, even better what would you be willing to do to get meds for 6 extra healthy years… wink - wink!
wink - wink!