Check out the HIV rates in Eastern Ukraine or the more Russian-parts of Latvia etc.
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Does anyone know if any of our “trusted” Indian vendors sell Descovy?
I usually get my Sirolimus from Apple Pharma but they don’t stock it, according to a search of their website.
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Maulik quoted me $20 for a bottle of 30 tablets. I have been happy with his service, quality and prices.
+91 99251 71777
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Thanks for your prompt reply and the number, but do you have a company name/website to go with that?
Shreejiimpex.co.in
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Am I missing where the study breaks down how the different dosing strategies used of 33, 66, and 100% where the last was daily dosing impacted the aging measures? Or is it only showing that the descovy group as a whole had those reductions?
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I’m much obliged!
Thank you!
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The study does not provide a discrete breakdown of the aging clock results (such as PhenoAge or DunedinPACE) for each individual dosing arm (33%, 67%, and 100%). Instead, the primary findings are reported for the “Discovy”,FTC/TAF group as a whole (N=36) , reflecting the pooled average across all participants in that study.
Here is how the study addresses the different dosing strategies:
1. Pooled Cohort Analysis
The significant reductions reported—such as the 6.33-year reduction in PhenoAge and the slowing of DunedinPACE —are based on the entire cohort of 36 participants. This cohort included individuals randomized to all three dosing levels (33%, 67%, and 100% of daily dosing).
2. Potential Attenuation of Effects
The authors explicitly acknowledge that the reported results may actually underestimate the drug’s potential. They state that because a subset of participants received intermittent (less than daily) dosing, it is possible that the biological effects observed were “attenuated” (weakened) by the lower dose exposure. This implies that the 100% (daily) dosing group might have experienced even more robust reductions if analyzed in isolation.
3. Dose-Response Mechanistic Analysis
While the “clocks” weren’t broken down by dosing arm, the study performed a separate dose-response analysis at the molecular level (CpG sites) to verify the relationship between drug amount and biological change:
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Exposure Correlation: Researchers modeled the change in DNA methylation as a function of measured intracellular drug concentrations (TFV-DP) .
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Significant Findings: They found that higher intracellular drug levels were associated with significant methylation shifts across 8,350 CpGs.
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Impact: This provided a “dose-associated” proof-of-concept, showing that the degree of epigenetic remodeling was directly linked to the amount of active drug reaching the immune cells.
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So from the little data we have we think daily is better. Thank you.
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Still if its something that has to be taken everyday, otherwize the benefit disappear, its really not interesting here. We have to find out if the result is real : sustainable. If you really reverse clock, if you stop clock should remain stable and increase over time from the time you stoped. Else its just noise to the clock to me
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Exactly. The good news is its quite an easy test for us to do…
- Do blood tests for PhenoAge calculations (or do DunedinPACE test)
- Take medication for 3 months
- Repeate blood tests for PhenoAge calculations (or DunedinPACE test)
- Wait another month or two (off medication)
- Repeate blood tests for PhenoAge calculations (or DunedinPACE test)
This medication would seem to be something the people in the Longevity Olympics (if that thing is still running) would like to do… perhaps squeeze out an easy win.
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Will you do it ? I want to see result 
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Yeah, why not. It’s human nature, everybody likes to be number one, or at the top.
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From what I’ve heard here the cost is only about $20 / month for the medicine, so a total of about $60. At some point this year, when timing is right, I can see trying this.
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Just another rusofobic myth, what should I say here?
HIV-denialism started on West. Duesberg, Maggiore etc…Responsible for hundreds of thousands of deaths (Thabo Mbeki and so on). But ofcourse there is always be some prick who will mention Russians in any case.
Уровень заболеваемости ВИЧ в России снизился до исторического минимума - РИА Новости, 29.04.2026 - Its historical minimum now, for HIV spreading in Russia. This is one of a numerous causes why people support Putin here. It was widespreaded in 90s, when its was a catastrophe of liberal democratic “win” over USSR. 30 000 000 of deaths for 10 years. Drugs, alcohol, violent crimes. And HIV. And no money to cure and prevent. Thanks to “freedom”.
In USSR there was the best in the world System of Common Healthcare. Completely free. For everyone. And all was destroyed. Thats why it led to HIV epidemic. + drugs (there were no drug problem in USSR. At all. Completely. So, no “social immunity” for this problem. Zero information about dangers. And when heroin flooded through Afganistan border - it became a disaster rapidly. With murderous gangs who controls traffic, with corrupted police and so on. 90s was a Nightmare on Earth.
But now - every year we cure some wounds from 90s. Step by step.
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Welcome back - I was beginning to think you were a victim of the Russian Internet blocking you from reaching us.
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)) I was blocked all the way from my first message here) Been using VPN from the start)
Its annoying, but its like rain. I think its a natural way of internet development as a system. Not too clever to be angry on the rain) World web will be divided on regions, and anonymity will be no more) BTW all these kind of news come last days not from China or Russia - but from Europe. They want to completely restrict social networks for everyone younger then 16 or something like this, etc
Personally, I think its BS!)
More connections between people - faster progress.
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I would be 100% pro this.
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I’m against anonymity on internet. In real life people feel boundaries of others, but here… It ends in overactive insults, false sense of unresponsibility for words and many more ugly things. We all have to log in with our passports (with real names and so on). Accessible at least for authorities.
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Btw, today’s news…
“Former CIA officer John Kiriakou said that the United States specifically promoted the growth of poppy crops in Afghanistan in order to get Russia and Iran hooked on heroin.”
Thats why any phrases like “Oh, lets keep Russians at distance, they do not believe in using anti-HIV medications” looks hypocrite.
Personally when I watch another youtube video from Kensington ave, San-Francisco - I feel shock every time. How can you ever criticize anyone, if it is possible in you own country? Such a hell on Earth. Poor people
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