I’m curious to know how you are using E3 if you don’t mind sharing. I’ve recently started 17 alpha E topical with transcutol. I’ve also been considering a topical E3 skin cream.
I alternate weekends (Fri, Sat, Sun) with rapa/E3 at 3mg each day, so about 18mg of E3 and 18mg of Rapa per month. I’m not sure on the systemic bio-availability of creams and hair tonics. I think the E3 creams directly on the genitals (scrotum) might have high absorption, but given the vast unknowns, that route is something I might only try if other options run out when I’ve very old.
1 Like
The addition of transcutol will enhance the transdermal absorption of 17 alpha E, but as you have said, it’s pretty much a guess. I’m applying it to my scalp since I have some male pattern baldness. It is thought to help with male pattern baldenss through it’s 5 alpha reductase effects. 17 alpha E was wildly successful on male mice in the ITP (+19%), so that’s why I’ve gone with it.
1 Like