author Mikhail V. Blagosklonny recasts hallmarks of cancer into a hierarchy of the hallmarks of aging, describing the hallmarks in brown (see figure) as non-life-limiting.
In the end, he concludes that only hyperfunction leads to age-related disease:
I think he too-readily assigns the label “non-life-limiting” to
- telomere shortening
- mitochondrial dysfunction
- non-life-limiting accumulation of molecular damages, not even leaving space for life-limiting accumulation of molecular damages.
His criterion for eliminating these three (and others unstated) is “Only the third criterion matters: (3) its experimental amelioration should slow down aging and increase healthy lifespan”
Is there no evidence that ameliorating these three items would not slow down aging and not increase healthy lifespan?