66M here. I saw my PCM for a routine health visit. while there it was discovered i hadn’t had the adult pneumonia vaccine shot. So I got it. then 4 hrs later i dosed 4mg with GFJ. After about an hr I realized i had gotten the shot earlier. Anything to be concerned with? I don’t think there’s anything i can do about it at this point anyways.
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Do you mean you were vaxxed twice?
Well, there are several such vaccines, so it depends. For viral I don’t think it matters, and possibly it could even be beneficial. For bacterial, it’s more ambiguous, but ultimately likely doesn’t matter - in the very worst case, you might want to get the vaccine again, this time being rapa free for two weeks before and two weeks after the shot (roughly following Mannick’s everolimus protocol).
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what do you mean, vaxxed twice?
The way you wrote it is unclear. I get it as you got vaxxed two times with the same vaccine.
all I know it was the adult pneumonia shot. I don’t know exactly which variant it was. i could find out tomorrow but I was worried tonight that i had done something stupid once i realized it after I had my sirolimus dose 4 hrs later.
I don’t see how you get that out of my post but no; I only had one pneumonia shot.
My local pharmacist keeps me up-to-date on all relevant vaccine shots for someone my age.Both my flu and pneumonia shots were formulated to be stronger than the regular vaccine because they are not as effective in older people.
Of course this is not medical advice, but if it were me, I wouldn’t worry about it.Unless you start to develop symptoms such as a fever. If you don’t have any negative side effects, you may have enhanced the vaccine.
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thx. I was worried a bit but also realized there wasn’t anything I could do about it after the fact.
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Let us know if you see anything unusual. Generally the research suggest (assuming you’ve been on rapamycin for a while) that you will most likely have a greater response to the vaccine than if you had not been taking rapamycin, because your immune system will be functioning better. But with regard to taking the rapamycin dose shortly after the vaccination, we don’t have any research on that, and I’m not sure if we’ve had any reports like this. So - just report what you experience, please.
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ok, I’ll report in a couple of days, sooner if i notice anything.
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I wouldn’t worry about it in the context of getting sick from the vaccine. However, I usually try not to time it the way you did. If I’m being vaccinated I’ll either skip a dose before or get vaccinated at the end of a dosing week say days 5-7 so the vaccine has some time to work while sirolimus levels are low. I have no evidence that my approach is any better than any other but you’ll recall that the Mannick study (everolimus) had a wash out period before vaccination after everolimus administration.
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How timely because I just asked about this in another thread for myself
The updated vax is out and I am anxious to get it.
It’s been 6 days since my last rapa dose and was wondering if I can get it now (the timing of feeling like crap happens to work out). It sounds like the general consensus is it’s more ideal to wait for two weeks after my last rapa dose, correct?
If it’s a wash, I’d get it tomorrow.
Have PCP check your titers ASAP for baseline and 4- 6 weeks after. Depending on which vaccine you had 13 or 23 valent you should see 2-4 fold increase, if NOT you may need to repeat the dose.
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I didn’t time it at all. I forgot I had gotten the shot…)
I understand, I thought my comment might be helpful for next time.
Yes new c-19 vax is out. I always get Moderna, but my CVS is only carrying Pfizer this time. It’s been suggested in the past that Moderna was slightly more potent, while Pfizer was slightly more problematic in sides. I don’t know what the current consensus is. Is there any reason that I should make an effort to get Moderna, or is that no longer relevant this time around, and I should just get the Pfizer as it’s more convenient?
Perhaps this needs a separate thread if the interest is high.
TLDR; I can’t find a reason to choose one over the other (Moderna vs Pfizer) yet but not all data on hospitalizations is available yet for the Moderna vaccine. Difficult to compare the two head to head as the two companies focus on different demographics but most data suggest they are very similar in efficacy.
Both Pfizer and Moderna vaccines are mRNA vaccines, there is a slight increased risk of myocarditis and/or pericarditis with mRNA vaccines. Initially Moderna’s vaccine was the most efficacious at the start of the covid pandemic so I think that gave them the “more potent” reputation but I think the efficacy varies from year to year for both companies and I don’t prefer one or the other anymore unless there is good data to support one over the other. I haven’t seen the data for preventing hospitalizations for the new Moderna vaccine yet but that may be coming out soon or may be published with real world data.
Pfizer’s announcement is here
And data on the efficacy trials is here
https://www.fda.gov/media/186597
It looks like the efficacy for preventing hospitalization is 43%-68% which is in line with previous vaccines for different variants over the last 5 years. 43% efficacious for a Kaiser study and 68% for a VA study. VA study was larger and older age than the Kaiser study but the Kaiser study was done more recently.
Moderna
Modena’s new Covid mRNA vaccine is called mnexspike which is a lower dose version (1/5 the dose) of spikevax. It appears to show improved efficacy over spikevax but hospitalization data is not publicly available yet making it hard to compare head to head with Pfizer. Spikevax efficacy for preventing hospitalizations was 45-46% so likely mnexspike will be in that range and comparable to hospitalization rates for the Pfizer vaccine.
mnexspike appears to be slightly more efficacious than the higher dose spikevax. Spikevax was 98.2% effective at 4 months post vaccination at preventing severe cases of covid19 in recipients 18 and older and 91.5% effective at preventing covid 19 in recipients >65 yoa 4 months post vaccination.
The publicly available efficacy data is here
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Thank you so much for that writeup, that’s a deep dive, much appreciated!
So 4 days later and nothing noteworthy to report. Other than a little bit of a sore arm at injection site for 2 days (which is normal for me) I didn’t notice anything else. I have been on rapa for about 12 months or so.
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