h i DL
what dosage do you take , and is it continuously or intervals like Dr Kaeberlein ?
hi VW
thanks for the follow up …58 , you’re just a kid !
I am in Canada have a good GP but can’t get involved asking her to do any Rapa directly related tests …yet anyway . So maybe I’ll try to correlate the yearly blood tests
When you suggest a low dose …1 or 2mg /week , I’m not sure what you mean , 1 or 2 mg tablet each day or once a week …? I am a newbie !
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Hello, back in 2018, with limited guidance i started taking an effective dose of 3mgs/weekly.
I say ‘effective’ to indicate I take 1mg/week with 6-8oz of white/pink grapefruit juice. This is said to effectively to triple initial blood concentrations and found this advice in Smithsonian Magazine when discussing how to avoid the side effects of 90mgs/day dosing as an anti cancer treatment. The alternate cancer inhibiting dose with GF juice was, if I recall ~25mgs/daily. That is an enormous dose as the half life of R is 3-4 days… so even a daily dose of 2mgs for transplant protection builds up over time to suppress mTOR2 (the innate immune system)
Of course this can also triple the dose of other meds and cause problems if another particular medicine is affected by GF juice. In my case, lisinopril, and pravastatin are not affected by GF juice.
I’ve escalated gradually until my last televisit with Dr. Green just two weeks ago who advised me to take 8mgs/week. He does not sportive of accelerating my dose with GF juice but i do so anyway. So I’m taking 3mgs/weekly and occasionally 4mg/weekly.
The central concern over dose is to get a FDA approved/tested supply. My first doses were Pfizer branded Rapamune. Later i wasted money on India sourced Biocon brand and last year on Amazon source sirolimus…quite dilute! Dr. Green sent my prescription to a local (to him!) Littleneck Pharmacy that sources from India, pharma ‘Dr. REDDY’ that i confirmed is an FDA authorized supplier of Sirolimus 2mg pills.
Dr. Green is on record for up to 12mgs/week for late 70s. He takes 12mgs/week now at age 80… his birthday was last week.
If i were you i would take an effective dose of 3mg/week and escalate that to 12mgs/week over the course of 2 months.
As a side note. Get a reputable supply to start with. I titrate my dose as dictated by the relief I get from severe arthritis of the hands/thumbs. So buying crap results in an obvious problem that i feel within two to three days following my taking this med.
My particular use of GF juice to boost my dosing is purely for the economics the GF juice provides.
After the recent increase to my current effective dose of 8-12mgs I’ve gotten mild mouth sores that i can easily control with acyclovir for a couple of days at most. Dr. Green up’d my dose from 6mgs to 8mgs partially due to my diagnosis of a low grade prostate cancer.
Your mileage will vary but don’t think mouth sores means your over doing it. Your body will adjust. Do take an inventory of aches and pains to distinguish whether they are generally from chronic inflammation or just too much gardening, or golf, etc.
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I take rapamycin every week at 10 mg per week. The first six months in 2020, I took 6 mg. Only negative has been 3 mouth sores during the first 2 years. One at a time, they each healed in 4 days.
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Hi Larry,
Welcome to the site. I’ve posted some general notes about the current thinking about rapamycin dosing that I’ve seen - here is a link to a specific post, but I recommend you review the entire thread: What is the Rapamycin Dose / Dosage for Anti-Aging or Longevity? - #197 by RapAdmin
Also - since you’re newbie to rapamycin - best to read up as much as you can here: Rapamycin Frequently Asked Questions (FAQ)
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I currently take the Biocon brand sourced from India. When you say “dilute” is this based on how you feel in comparison to Rapamune? Or is it based on blood test results?
I was encouraged by the lab test results posted below but your feedback does give me cause for concern
I thought the testing showed that the Zydus and Biocon brands had 110% of the Rapamycin found in Rapamune. This would make them stronger not weaker.
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I am unusual in that I have severe arthritis of the hands that responds very well to Rapamycin/sirolimus. It was my experience 4 years ago to get a very dilute batch of it from Biocon. I would have to guess but I felt that I had to take 5x what I was taking from Pfizer Rapamune to equal the net effect of the Biocon on a mg per mg basis.
Is Biocon an FDA recognized and approved provider of generic Sirolimus? I know that Dr. Reddy is. I do not doubt Biocon was selling sirolimus. I did doubt its reported potency. Try and find only those pharma’s with FDA recognition.
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I take Amazon source sirolimus - manufacturer - Glenmark. What make did you get from Amazon? How did you know it was “quite dilute”? Thanks
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Glenmark? Yes I just finished most of those when i got Dr. REDDY’S from Little Neck Pharmacy. I do not think much of it.
My ‘immediate’ indicator is how much pain i have on my hands from arthritis. I immediately knew Rapamycin helped when i started taking Pfizer Rapamune. Shifted back and forth to Biocon and each shift showed a marked change in the often sharp pains in both hands.
Glenmark’s 2mg pill seems about 50% the strength of the one from Dr. Reddy from the pharmacist Dr. Green recommended.
Feeling is believing!
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Anecdotal, not scientific, but in my case quite ‘observable’.
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Im 75 and in good health. Started on the AgelessRX Rapa trial almost two months ago. Took my last 10mg compound form of Rapa on Saturday. Next weekend i’ll be taking 15MG of the compound formula and after a month on it I expect I’ll be going for more blood work that they pay for. Was out for my 90 mins bike ride today. Usually get out at least four days a week which has kept me feeling a lot younger then 75. My Biological Scale claims Im 40. Weigh 137lbs. BMI 22.9 Body fat 18.3% Muscle rate 76.6% Subcutaneous fat 13.1% Visceral fat 11.5%. Still working on getting the Visceral fat a little lower.
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I was using Dr. Reddy - Sirolimus with Cigna Insurance… now with Anthem… using Greenstone Rapamune… will see dose in blood in a few days from a blood test.
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Greg thanks for that information , I am in Canada and I haven’t heard of or located a doctor like Dr Green \ my GP is good but like most of them is not focused on healthspan
so I’m thinking I will have to go w India
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thanks Admin
appreciated
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Hello Greg, I’ve been reading this thread and thought that I would ask you a few questions.
Can you tell me how to contact Dr Green? Does he do telehealth for out of state folks? I am assuming that he is not in Illinois where I am located.
I live 40 miles West of Chicago, and I’ve looked, but under what specific specialty do I look to find a Dr like Mr Green? Loyola University Hospital has a geriatric group, and the subject of taking rapamycin is age related but I think that I’m using the wrong search criteria.
Due to what I’ve read on this site regarding bioavailability / absorption I think I’d like to stick with Rapamune. How hard is it to get Dr Green to prescribe that? I think that you said Dr. Reddy’s is good rapamycin and that you get it from Little Neck Pharmacy. Is that in Arkansas? Does it have a coating on it?
Thank you for your responses ahead of time!
I asked OpenAI GPT-4 the following question and it points me in the general direction. Thought that I would share the information with all of you. If this is not correct information, then please correct it.
Q: Which specific type of doctor might discuss with me the benefits of Rapamune for anti-aging and write a prescription for me?
Rapamune (sirolimus) is an immunosuppressive drug originally used to prevent organ rejection in transplant patients. Some research suggests it may have potential anti-aging benefits. However, it is not yet an FDA-approved treatment for anti-aging, so it’s essential to approach this topic with caution.
If you’re interested in discussing the use of Rapamune for anti-aging, consider talking to the following types of doctors:
- Geriatrician: A geriatrician specializes in the healthcare of older adults and may have knowledge of potential anti-aging therapies.
- Endocrinologist: An endocrinologist specializes in hormone-related conditions and may have insights into the potential impact of Rapamune on the aging process.
- Internal Medicine Specialist: An internist focuses on the diagnosis, treatment, and prevention of adult diseases and may be able to discuss the potential benefits and risks of Rapamune for anti-aging.
Please note that prescribing Rapamune for anti-aging purposes would be considered “off-label” use, meaning it is not FDA-approved for this specific indication. As such, some physicians may be reluctant to prescribe it for this purpose. It is essential to have a thorough discussion with your doctor about the potential risks, benefits, and alternatives before considering using Rapamune for anti-aging.
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Dr. Alan Green is based in NY. You have to to there. See our list of doctors here: Rapamycin Prescription, Doctors that Prescribe It
Rapamune is expensive - see the pricing here: How to buy Rapamycin (Sirolimus)? What is the cost?
Most of your questions are already covered here: Rapamycin Frequently Asked Questions (FAQ)
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Chat GPT is not very good when it comes to longevity and rapamycin… don’t rely on it, it makes stuff up all the time (cites references/papers that are not actually things that have ever been published, etc.).
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ChatGPT is great if you are writing code, a piece of fiction, or a highschool book report.
It’s not so great when you want detailed, factual, and reliable information about a specific advanced topic. Rapamycin use would be one of those advanced topics.
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