Greg Fahy: We may have discussed what this guy is doing but can we talk more about him

Many studies over the past 40 years have confirmed this is the way to go.

I still prefer to use Secretagogues as opposed to a hormone replacement therapy.

My thought is that it keeps the system that is suppoed to do this function working as opposed to putting it to sleep and degrading another process that can still function with a bit of help.

While this one is only 15 years old, there are others going back into the 90’s

1992
https://www.sciencedirect.com/science/article/abs/pii/088915919290033K

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My only concern with using secretagogues for thymus rejuvenation is whether Fahy-level dosing can be achieved.

The TRIIM protocol is
"During the first week of the trial, rhGH alone (0.015 mg/kg) was administered to obtain an initial insulin response, and during the second week, rhGH was combined with 50 mg DHEA to evaluate insulin suppression by DHEA alone. During the third week, the same doses of rhGH and DHEA were combined with 500 mg metformin. Beginning at the fourth week, all doses were individualized based on each volunteer’s particular responses.”

Can .015 mg/kg equivalent of HGH be achieved with ibutamoren?

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I think that’s a solid dose and I probably wouldn’t push it higher than that for the reasons we are using it for. Notice any water retention at all?

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Hey Luke… yep, as with all dosing looking for the sweet spot… too low nada… too high poison. I think 3.3 iu has been perfect.

As to water retention, initially I went from 190 pounds to 202 pounds in a week strictly water weight gain.

TBH - it was cool to be a 200 pound beast for once in my life. Biceps and chest were swole… Hahaha.

But that water retention resolved itself in a few weeks. Now been 188 to 191 for past 4 months no issues.

My first 9 shots alternating around my belly button was getting a small reaction of heat/fever… hardness and swelling. Switched to alternating butt cheeks. Had a little heat and swelling there too… for a week. Then it stopped. Yeah!

Last 4 months no injection issues. All great… definitely getting great skin quality results in forearms and neck.

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That’s awesome. Thanks for sharing and keep up the good work.

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Fahy’s patent suggests titrating secretagogue dose based on IGF1 levels, targeting at least 170 ng/ml, but preferably not a whole lot higher to minimize risk.

In my experience, this is easily achieved with 5-nights-per-week dosing of ModGRF1-29/ipamorelin (100/100 ug). Ibutamoren should also be able to achieve this.

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Thank you, that’s very helpful
thought it might be interesting to post the patent here:

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Just looking at some dose-response for Ibutamoren. The Fahy patent is targeting either a 1.2 fold increase in IGF-1 or 170 ug/l absolute level. These results are from a study of 9 low igf men given either 10mg or 50mg per day of Ibutamoren. 10mg/d dose would seem to be enough to achieve x1.2 in IGF-1

The patent also talks about targeting CD4/CD8 ratio. Is anyone doing this to see if it’s working?

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one other candidate for Fahy’s new/secret protocol: boron. It seems to boost FOXN1 expression.

This study is (bizarrely) in ostriches:

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Nice! I have been on boron past 5 months… due to posts on this site.

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Ibutamoren MK 677 may soon become a bit more difficult to get… or not. My current supplier will not provide Ibutamoren any more due to export restrictions.

There is a “new” version Acetamoren MK 777. It will probably become the standard oral secretagogue for hGH in the near future.

From various things I’ve read, acetyl versions of peptides are “better” than TFA or other versions. While Ibutamoren is not a peptide, it may be possible that this acetyl version is better? and may provide the same boost in hGH at a lower dose.

CAS Number 950841-87-9
Other Names Acetamoren, MK-777
IUPAC Name Propanamide,2-(acetylamino)-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4′-piperidin]-1′-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-(ACI)
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It might make sense to patent your stack!

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I have a remarkable instinct and sense for what to do - premonition… psychic. My gut instinct is always spot on.

Comes from my Bohemian genetics thru my Czech mother… grandmother… and great grandmother :laughing:

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My first biological test is in the lab to see if HGH is making any difference. TruMe epigenetic methylation spit test.

Should have something to share within 10 days.

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How long would you suggest (i.e. 15 minutes X 2 per day=ok?)

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I like the sauna at around 175°F for greater comfort. 30 min x 4 days a week, minimal.

If twice a day, also 30 minutes each.

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So here it is. Epigenetic Methylation DNA spit tests.

I know some struggle with biological age markers from tests. But even Matt Kaeberlein says they tell us something.

I like TruMe… because they don’t want to throw out unbelievable age regression. They know even the best longevity protocols might give you a few years. Yelena Budovskaya Ph.D. Longevity researcher at Stanford is looking for the outliers.

So when I took their biological age test in 2021 and scored a 12-year differential from my chronological age… they didn’t say wow… lucky you. No, they assumed they made a mistake in processing my specimen. And, retested. Lol.

Once they confirmed the results were accurate. Their CEO, Yelena, wanted to know what I was doing for lifespan? Rapamycin was my answer.

Pretty funny and I was equally surprised how rapamycin was significantly helping me.

I take this test about every 6 months. I was still getting good results averaging 10-years benefit… more recently only about 8-years younger. Should I complain. Hahaha - yes! Hell… I had 12 years.

After 5 months of daily 3.3 iu HGH… I am back baby. Twelve years younger biological age. Dr. Fahy says the bigger age reversals come after 12 months of HGH use and the thymus is fully rejuvenated.

Can’t wait to retest at 12 months, maybe I push beyond 12 years. I received a link from TruMe and will be chatting with Yelena about my results with rapamycin and HGH soon. I will share what I learn.

Should have my GlycanAge results in 2 weeks… inflammation testing. Will it too show a great result?

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As promised, I did get the opportunity to talk with Yelena Budovskaya, Ph.D. Stanford. Our chat was delightful and covered her TruMe test, and aspects of longevity related to rapamycin & HGH. Going to share that conversation with you now.

Beginning with my TruMe test results showing an 11 years 7 month difference between my biological age and my chronological age.

Yelena is quite honest that my test results are very impressive and is atypical based on her years of testing others ranging from the 30 to 80 years old. If looking at the percentile of people that are at my kind of age difference level, she said I’m in the 99th percentile. Pretty astounding.

That said, Yelena cautions that not everybody might get the same results as I have from the use of rapamycin, an immune modulating substance. So many variables are at present in the population.

Factors for maximum benefits can include at what age you begin, your genetic makeup, your fitness and exercise level, diet, the dosage and frequency of rapamycin use. And, even the quality of the rapamycin that you are using… if you’re not getting your rapamycin directly under a physician supervision through a pharmacy.

Yelena is very sincere in her concern about individuals doing experimenting with this autoimmune medications like rapamycin unsupervised. It is very possible that the use of rapamycin for some people can be be more harmful and dosing levels should not be taken lightly. Can definitely do more harm than good in some cases.

That said, we all realize how difficult it can be to find a physician that might align with your longevity interest. And, support your usage of such medications like rapamycin, hgh and hormone replacement- to name a few.

I was surprised to find out that she is currently in collaboration with Matt Kaeberlein and trying to tease out results those from taking rapamycin and utilizing her TruMe test. What the actual benefits may or may not be… she contends it is difficult work to identify what is happening in each unique person.

I did mention that Matt has been taking rapamycin for a number of years and is a strong advocate of rapamycin’s anti-aging - longevity benefits. I inquired is taking rapamycin something that she is doing or would consider?

Actually, she has thought about it quite a lot. And, my testing results makes an even stronger case as a potential longevity option. But, currently she is in a clinical trial with NAD, and has promised not to supplement with anything until that is completed.

However, once that is completed, she is strongly thinking about going on rapamycin. I would like to see her baseline test… then at 6 months use and then after a year’s use. :wink: I highly recommended to her several times that she come to the rapamycin.news website so that she can ask questions, and get information from the members.

Also, looking at human growth hormone HGH, she believes that it could be contributing to my additional restored benefits. The recent bump based on a rejuvenated thymus. She’s familiar with Dr. Fahy’s work. Again, as with other medications, you want to make sure you’re getting quality material and under a physician’s supervision. She doesn’t disagree that, a short term use of HGH to rejuvenate the thymus could provide benefits for some people. Dr. Fahy recommends a full year.

As a scientist, she wants to help people with their personal longevity quest. And, therefore, she offers her TruMe lab’s spit sample - methylation DNA biological test as cost affordable as possible, to help people navigate their aging process and have positive effects on it. Link: trumelabs.com

She is looking at a future blood test, but obviously more infrastructure is required for testing… but even more information can be culled from blood samples. That’s in the future she hopes.

In closing, Yelena is a knowledgeable, relatable, down-to-earth, enjoyable person. In the caliber of Matt Kaeberlein, thorough in her research, truthful about results and is driven by the evidence. And, has a great sense of humor too. I easily could have gone on for hours. Was thankful for the time she did provide me. She offers a free consult with her test. Incredible. This was my second interaction in 4 years. We covered a lot of ground… learned more than I can relate in a message here.

@Krister_Kauppi…have you thought about an interview with Yelena? If interested I have her direct contact info.

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Bud, you are giving to much credit to Rapa, If I remember correctly last time you posted your result a year ago or so, it was between 5-7 years, very impressive but not as good as 12 years you’re getting now. Well, then there comes the obvious question what changed? I’ll tell you what changed… You started HGH 5 months ago and that catapulted you to the top of the pack. Prove me wrong :joy::joy:
Plus, the last pic you posted you were day and night (as in better shape and complexion) than a year or so ago. Well, what changed? I guess you know what changed and could not have been Rapa… :joy::joy:

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I agree… the HGH… got me back to where I was just on Rapa the first 2-years. I am aging… just hopefully slower. :wink:

My physician and I believe in the combo… rapamycin, TRT- hormone and HGH.

Will be curious if the benefits of HGH… build on past success. Dr. Fahy in a recent podcast was citing 12-13 years biological benefits on 2 users of several cycles in his protocol.

He himself looks amazing at 75 years… born in 1950.

https://g.co/kgs/RY3JZ3C

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