Thank you. I will now try to do the same. I will take glycine and NAC before bed. I did so last night and I slept 6 hours before waking up first time. I had more than normal amount of REM sleep and deep sleep. This is ofc only one night so far. But I will post my feedback after a week or two.
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Chase it with a pleasant bitter taste - coffee or cacao.
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The text of the image you posted says those are false result; a mere interference in blood tests, not a true physiologic result. Skipping a day before blood draw solves it.
NAC can interfere with results of blood tests for cholesterol *including HDL-cholesterol) and uric acid, showing falsely low results, but this effect is mainly of concern when large doses (several thousand milligrams are given within 12 hours before blood draw, such as when NAC is given intravenously to treat acetaminophen overdose. It is very unlikely that typical oral doses of NAC will cause interference, but to eliminate the chance of interference, you can avoid NAC within a day before blood tests.
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Yes, it gives a false result in blood tests. But for those of us who take NAC daily…
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GlyNAC versus TMG-NAC?
I’m considering adding TMG (Betaine) as a supplement. It’s said to be useful for muscle growth, mental health, DNA methylation, etc. and it is a form of glycine. Any thoughts on using TMG as a replacement for glycine making the combination TMG-NAC instead of GlyNAC?
I keep trying to find ways to reduce or consolidate useful supplements and this may be one way to do it.
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Isn’t that too big of a daily dose? Did you start small and then ramped up?
Hi Ruben, I chose the dose based on the following study. GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study. They used 100mg/kg/day of both glycine and Nac. I am 80kg so that equates to 8gms of each per day. Other studies were in the same ballpark with most being a bit lower.
I scaled down the Nac to 6gms daily.
I started out with the full dose of each, but I can see the wisdom of working up to the final dose over a week or two.
I have since added 1gm of taurine to the bedtime dose and have added 5 more grams of glycine each morning.
Sleep is almost always much better than my baseline even after 4 or so weeks. Pickleball endurance also better.
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