I noticed that the Incidence of brainfog was reduced to almost none. There was brain fog one day, when I had more coffee than usual. I had a lot more energy, was in a great mood, and felt much more stress-resilient.I had 10 gr on empty stomach and a few days I allowed myself to have a small amount of coffee, 1- 2 hours after the Taurine. But if I had more coffee than I crashed. (which I did one day). The positive effect showed up already on the first and second day.
I have stopped taken 10 gr Taurine for a few days. Soon I will repeat the experiment. and see of the effect is repeated.
Iāve been hearing people say GlyNAC is useless if youāre under 45 years old. I am aware of the study that showed 2.4g of each NAC and Glycine had no effect on the elderly when it came to boosting glutathione but 4.8g and up did (after two weeks).
I wonāt stop glycine since itās in the collagen peptides I take but Iām wondering if I still should be taking NAC. Iāll be 39 in a month and a half.
This is pretty alarming news for those of us who, like you, have a heightened concern about nephrotoxic agents. I think the risk is sufficiently high for me to consider removing rapamycin from my home pharmacy. Thank you for the alert. News like this is what makes the site so valuable, whether rapa is on the menu or not.
Rapamycin can cause nephrotoxicity in some patients with chronic glomerulopathies. Whether the toxicity is solely related to rapamycin, due to the combination of proteinuria and rapamycin, or other unknown factor use is presently undetermined.
yes I weigh the taurine on a scale, before I take it. I have noticed that the volume is approximately 10 ml= 2 teaspoons. I use the powder from NOW food.
Regarding the idea of Glycine + NAC, I would speculate that if you are someone who eats a lot of animal protein-based foods, whole grains, and maybe nuts/seeds, then you might not really need the NAC. Take a look at this list of foods highest in cysteine: Top 10 Foods Highest in Cystine (Cysteine)
However, the glycine is a different story. Other than collagen-y kinds of meats (tripe, pigsā ears, bone broth, other kinds of foods that even pretty healh-conscious folks typically donāt eat much), there arenāt many sources of glycine. Thus, depending on your diet, I canāt help but think that glycine is the most lacking ingredient here for many, except for those who supplement with solid doses of collagen regularly.
What you say makes some sense at first glance. However we know for a fact that after the age of 45, the amount of Glycine and Cysteine our bodies have decreases steadily. I doubt itās because our diets have changed, but more of the fact that our bodies cannot produce or extract Glycine and Cysteine from food as well as they could when they were younger. Thatās why itās necessary to supplement both.
It reminds me of people saying thereās no use taking rapamycin unless youāre old. Yet in animal models the younger they start the better, and that is true for all interventions with effect.
We are detrimentally aging way before we are considered old.
Itās not clear whether glynac works at all but if it does younger will probably be better.
That may be one reason that glycine and cysteine decrease in the body with age. The other reason could be that our bodies are pretty good at making these aminos when weāre younger ā even when not actually getting any of them from food at all ā but lose the ability to produce them when older. (That might be part of the reason that young people can have absurdly poor diets and yet maintain pretty good health/high glutathione.) Cysteine, for example, is produced in the liver from methionine (see https://www.mountsinai.org/health-library/supplement/cysteine). I imagine, like many processes affected by aging, this process probably runs pretty well when youāre 20 years old, but starts to break down by age 45 or so. Thus, getting plenty of cysteine from food as you get older might be a way to ensure glutathione doesnāt begin a precipitous decline. Iād consider taking NAC as well, but it does appear that NAC might be something of a double-edged sword in some ways, which is why Iād like to imagine that getting adequate cysteine through food is a possibility.
I have been taking 8 gms of Glycine, 6 gms of NAC and 8 gms of natural clam at bedtime for a week. It has literally been life changing. My sleep has been messed up for 35 years from taking night call. Since Glynac/Mag, I have had over 7 hours of blissful sleep each night. Crazy wonderful dreams. Very rested. More energy and better pickleball. When I wake up at night, I now fall right back to sleep. My wife having the same experience.