Hasn’t affected mine over the last three years I’ve been prescribed! Yes, therapeutic dose is anywhere from 10mg to 60mg per day.
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I leaned the hard way that it is important to drink a big glass of water when taking NAC. Apparently, it is very acidic. Btw, has anyone noticed a reversal of presbyopia? I have been taking glynac and taurine on alternate mornings, and I think my eyesight is improving. Or perhaps it is all of the carrots and parsnips I’ve been eating.
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Yes. I’ve noticed my eyesight is getting better, but I wasn’t sure what to attribute it to.
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I’ll just share the couple of notes I took:
He takes 600mg per day … 1200 on occasion.
He said try not to take it with a lot of protein
Ideally take it on an empty stomach, but you might want to try taking it 30 minutes prior to a meal to avoid digestive issue.
I’ve been taking 100mg of NACET… I wonder how that compares to NAC.
And wow @Ray1 and DeStrider about your eyesight improving!
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Glycine at this point I think is the single biggest thing in my stack for cutting fat…
I take A LOT of stuff…
prescription - rapa/simvastatin+ezetimibe/jardiance 25/telmisartan 80/sirt 6 activator - well, not prescription/prucalopride/dutasteride/high dose acarbose 600 now 300 twice a day with or without food/
non prescription - novos core and the 12? ingredients of that. vitamins a/d3/k2/magnesium/zinc/psyllium husk/melatonin 40 a night high dose
I’m a light smoker with the same workout routine of the last many years - body by science…
anything else that im missing…
But, my fat fluctuation really fluctuated when I took a 2-3 month absence from high gram glycine. for the last year and a half I took high gram glycine and stopped and just packed on the belly and excess fat. I think glycine is the key ingredient here, so I am back on it.
I’ve always debated NAC. I take novos core and follow a lot of their lead and they always mention it as an iffy ingredient - 8 Anti-Aging Supplements You Don't Want To Take
- N-acetyl-cysteine (NAC)
Some studies show that N-acetyl-cysteine (NAC) can extend lifespan, mostly in simple organisms (R,R,R), but also in mice – however in mice the results are open to interpretation (R).
Other studies show that NAC actually shortens lifespan (R).
N-acetyl cysteine is a strong antioxidant. As we explained before, many antioxidants do not extend lifespan, and can sometimes even shorten lifespan.
Studies also show that NAC can increase the spread (metastasis) of cancer (R,R).
Which makes sense: cancer cells are fast dividing cells that don’t regulate their metabolism well, so they produce lots of free radicals.
Antioxidants like N-acetyl-cysteine mop up these oxidants, something which is very helpful for free-radical ridden cancer cells.
So to err on the side of caution, we currently do not advise taking N-acetyl-cysteine.
But I think I will give it a go and start to add some NAC to test it out
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I was messing with high dose NAC and glycine when I got afib. Somebody else on here mentioned it can mess with heart rhythm. I’d just say don’t go really high. I was taking several grams.
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It would be helpful if more people stated their current dose…
I’m still skeptical of NAC, so I won’t go beyond three grams, though I still go ham on glycine which I think is a more proven healthful substance (15-20 grams a day)
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After more consideration I might just stick with glycine and no NAC, which hopefully is enough to raise glutathione by itself
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Glycine will raise glutathione, but not as much as Glycine and NAC. I take 4 g of NAC daily along with plenty of Glycine.
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To be clear, you developed afib on high doses of each? The wording confused me a little.
I developed the afib and was doing a number of things which could have contributed as well. After reading what other people on here thought of NAC, I decided it was probably NAC. I kept taking large amounts of Glycine and the afib went away. I’ve had no trouble since.
I was on Rapa and went pretty strict Keto and ran 2 miles a day for over a year. I think I overdid the exercise a bit…lost 25 lbs. I still think it was the NAC
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How high did you go with the NAC doses? I’m not doubting that it was the NAC but the elderly people went as high as 9g if I remember correctly and I didn’t see any reports of a-fib.
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Alan Greene was the one that got me on Gly Nac. His site probably has the study of elderly people that took it and got much better, I’ve forgotten where it came from but was well done. I used the formula from the study and he used it too. I think it was 9 grams of each/day. I did this for quite a while and did think it made me much stronger. I tapered right down after the afib. Nothing like a visit to the ER.
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It looks like you’re unfairly blaming NAC for your afib. Even intravenous NAC not only doesn’t increase afib risk but actually decreases it:
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I’m taking glycine anyway, so I’ll add back a gram and see what happens. Thanks for checking.
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I’m not sure if this holds any weight but I’m using NAC specifically to lower my histamine. Although I’ve never been tested, I seem to have histamine intolerance/MCAS. My histamine spikes fairly regularly and NAC has been a lifesaver. It’s quick and effective.
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This is extremely interesting.
I’va had severe insomnia recently on several occasions, often accompanied by itching. It’s finally chatGPT that suggested the culprit was histamine, and indeed, on the worst insomnia nights, I ate a lot of high-histamine foods, and cutting them out stopped the insomnia. Later, my doctor prescribed me an anti-histamine, and while I don’t want to take that long term (it’s more of an experiment), it definitively helps me sleep.
How much Nac do you take to help with histamine?
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I find the same thing for myself. When my histamine is up I tend to have hot flashes which makes it difficult to sleep. I have 600 mg capsules and I take one at a time. If my histamine is just starting to go up, only 1 capsule will nip it. For a severe attack I keep taking capsules until I get relief. There have been a few times that I needed at least 6 capsules over the course of a few hours. That’s rather rare though.
Since we’re talking about difficult sleeping… that’s been an ongoing issue over the past decade for me. I started using sermorelin and at the very beginning it helped. Then the honeymoon was over. After about 2 months of sermorelin I added VIP. I find that I fall asleep faster and stay asleep longer.
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