We don’t know, but it is possible. This could be a way of experimenting with even higher doses but allow it to get out of the system in the 2nd week.
I plan on sticking to once a week since it works well for me. Some people have experimented with smaller doses more often in the week to reduce side effects.
Hi All, only sharing the end point of the health coaches I’m with say re treating GLP-1s like HRT.
2-2.5mg tirz or reta IMHO are “full doses” not micro dosing or anti aging levels. Too high.
For low level appitite control, at 170# metabolicly healthy, I’m micro dosing 0.250mg every other day a mix of tirz/Reta at 50:50 which stays under 1mg/wk. Some might bias this ratio to 30/70 tirz to reta. Reta offers little appitite control so folks take reta for better body composition changes (grow more muscle then other glp-1s) and tirz for more appitite control. Some just do semiglutide with reta. Extremists dabble with cagiliride (??) an extreme appitite control.
For pure anti aging my input from coaches is: <1mg/week but dosed as often as your jabbing and logistics allow down to daily for some extremists. The ideal for either weight lose or anti aging is flat glp-1 levels. I’ve not read any benefit to letting glp-1 levels drop so you are back to being hungry!!! Except if you subscribe to 1 day a week binge eating to keep basil metabolism up. Tim Farris pitched this 10yr ago, some coaches re plateuing and dropping basil metabolism, suggest to reset metabolism with a binge day (shades of grey).
If you move to insulin pens, a topic in itself, its extremely easy, quick to jab. Litterally 5 sec or so from grabbing it, jabbing, putting it back.
I buy this cheap pen; https://toadspens.com
Its cheap. I do wish I would move to a pen with a flip cap end so I don’t have to fool with the tinny needle cover on and off. Just a process improvement. I have 30 of these loaded up with all things under the sun. I’ve moved to injecting in tracks up each leg. The belly and love handles get sensitive with so many daily sticks. Just another step to drop the pants, sit on a chair, let the pens rip, put everything back into a plastic box off amazon…
Best of luck, curt
I’d go for a steady state over peaks and valleys, with reta at 0.5 mg/wk. Same with rapa at 1 mg/day.
Good idea with pens. I’ve been considering making the move for a while.
I disagree with a blanket dosage recommendation being anti-aging. Different people with different needs. If you don’t have other conditions that respond favorably to higher doses of GLP1RAs then you might do well with microdoses.
“Proven” is a strong word, but GLP-1RA are associated with significantly lower rates of dementia in multiple studies, comparable in effect size to SGLT2i. I personally don’t take glp-1 (I do sglt2i), but I found the evidence convincing enough (though not “proof” level) that I’d be willing to take it for preventive purposes if I were ApoE4/4 (I’m 3/3).
I’m monitoring the literature and cogitating, with a view of perhaps one day springing for something like small dose semaglutide. Not ready at this point (he says at 67🙄).
But is that association due to anything other than treating diabetes or obesity? Were the studies done in normal weight non diabetics?
They controlled for that, at least to a degree. Because the comparators were other anti-diabetic drugs. Those other drugs also normalized glucose, just as glp-1ra did, and also lowered weight. And against them, glp-1 (and sglt2i) drastically lowered dementia rates. FWIW, controlling for obesity and diabetes did not change the results - the glp-1 dramatically lowered dementia rates. Here’s one example (there are many others!):
Exploring the neuroprotective role of GLP-1 agonists against Alzheimer’s disease: Real-world evidence from a propensity-matched cohort