I came very close to trying this a few years back. But I didn’t have the 15k to sign up to Steve’s service and I wasn’t comfortable titrating this myself because it’s measured in picomoles. The results still sound impressive. I guess the only way to find out is to try jr.
Apparently, it is also good for the skin.
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Yes. I went over the data from Steve’s cohort and there was apparently an improvement in skin elasticity. I was interested in its effect on the heart and organ remodeling via the Hox gene. If anyone is interested in trying it on this site can figure out the titration I’d be happy to join in.
GDF11 is a big protein hence one would assume it has a big gene. That probably is behind a reduction in production of GDF11.
The broader issue of stem cell generation is clearly linked to activity although obviously if some of the key proteins as part of stem cell production are not produced that will be an issue.
To me the core issue for stem cell production is activity. This I think operates through the HIF within cells, there must be something between cells, but I don’t know what this is.
I might be interested if you have a reliable source.
It’s been a while since I looked into it. I’m pretty sure Buckylabs sells it. It’s not expensive
Yes, I’ve spoken with Darren there, who seems honest. Just wanted to see if there were alternate sources.
There used to be I think. The law changed and now I think it’s much harder to get.
15,000 USD per year? One time cost? What is the monthly cost?
Steve’s presentation is pretty impressive.
I don’t think there is a monthly cost. GDF11 for the year is about $600. It’s all on the website. But you technically don’t need to pay anything. You just have to make sure you’re titrating the right amount. The 15k is to track your markers and I think if you’re going to use something like this then it’s vital that you keep track of it.
Here’s a link to Steve’s site.
Same here. I think the level of proof for injections is much higher than for consumables. My liver is designed to protect me from foolishness. I just need to avoid killing my liver.
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I’m back where we were at the top of this chain, wondering whether GDF11 is responsible for the benefits of E5. He said it’s the same in all mammals and it’s in larger amounts in the younger ones. The dosage of GDF11 is tiny.
It does not look that dangerous. If I had cancer I’d give it a try. He claims to have taken a dose just a WAG, had bad side effects, took a break, took half the dose, Bad side effects, took a break, took half the dose and that’s how he figured out what dose to take. Seems simple. Skinny people need less. I’m going to pass for now because I actually feel pretty good, but it looks promising.
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Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation
Acute endurance exercise modulates growth differentiation factor 11 in cerebrospinal fluid of healthy young adults
(Haven’t read them detail)
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Does anybody know if there is a lab test available for the public on GDF11?
I searched on LabCorp website and googled gdf11 blood test and nothing seems available in clinics. Seems to only be a research type of test for now.
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Thanks, same with me. I think it would be an interesting test to have around. Like my daughter with cancer, if they could test they may find she is short and it could be supplemented. It would also help with titration to determine the dose.
BTW, my daughter had a scan at the university of Iowa yesterday and she was declared No Evidence of Disease. She’s more or less clean. Hooray! I think she’s going to keep up with the treatments she’s been using since they are mostly vitamins anyway.
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I’d keep up the treatments for a while longer. Cancer is insidious. Just because it can’t be detected doesn’t mean there aren’t a few survivor cells hiding. Be vigilant and don’t let it make a comeback! However it’s wonderful news that she is better.
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https://sci-hub.ru/10.1161/CIRCRESAHA.116.308478
This says the whole thing with gdf11 is just a mistake.
Also Steve says you have to take it frequently for awhile, then still a couple times a month. E5 is supposed to be much less frequent.
Yes, I realize I’m arguing with myself.
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Not sure I understand
I thought the animal studies (a large number of them now, many in great journals) are controlled, where some animals are given GDF11 vs controls are just given placebo. Hence any effect in the treatment is causally due to the GDF11.
Are you saying that anyone is questioning that?
Sometimes you have to click the link in your browser to make it load, I don’t know why.
The writer says GDF8 also called myostatin is hard to distinguish from GDF11 and he claims they find GDF11 goes up as you get older. Very confusing and I’m no biochemist. Also this is from 2016. Beats me, I just saw it and thought I’d share.
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